Articles Related to Treatment
Outcomes Following Debridement, Antibiotics, and Implant Retention with the Exchange of Modular Components in Hip Periprosthetic Joint Infections
Shin Onodera, Motomi Ishibe (2023) Outcomes Following Debridement, Antibiotics, and Implant Retention with the
Exchange of Modular Components in Hip Periprosthetic Joint Infections. J Orthop Physiother 6(1): 101
Recurrent Ophthalmic Eczema Herpeticum with Hyper Immunoglobulin E Syndrome in A 4 Years-Old Boy
Eczema herpeticum (EH) is a skin infection caused by the herpes simplex virus (HSV) that occurs in individuals with atopic
dermatitis. It is characterized by the sudden appearance of vesicles and erosions with crusts over areas affected by eczema.
EH can range from mild and self-limiting in healthy adults to life-threatening in children, infants, and immunocompromised patients. Early treatment with antiviral therapy is crucial in preventing complications and mortality. EH is primarily
caused by a superinfection of HSV, usually HSV-1, in individuals with atopic dermatitis. Reactivation of HSV is more common than primary infection. Patients with atopic dermatitis are more susceptible to skin infections due to impaired skin barrier function and immune dysregulation. Disseminated cutaneous HSV infection can also occur in individuals with other
forms of dermatitis, known as Kaposi varicelliform eruption (KVE)
Case Report: Pyoderma Gangrenosum in IBD Treated with Tofacitinib
Pyoderma gangrenosum is a rare ulcerating skin disease often presenting as an extra intestinal manifestation of IBD and is
difficult to manage. Treatment options for pyoderma gangrenosum include steroids, calcineurin inhibitors and anti TNF
agents. Here in, we report a case of recurrent Pyoderma gangrenosum with Ulcerative Colitis that was successfully managed
with Tofacintib, a JAK inhibitor
Dosimetric Comparison between Intensity Modulated Radiotherapy versus Volumetric Modulated Arc Therapy Treatment Plans for Breast Cancer
This study compared the dosimetric characteristics of Intensity-modulated radiotherapy (IMRT) and volumetric
modulated arc therapy (VMAT) techniques regarding target volume coverage and dose to heart, spinal cord, and lung for
patients with breast cancer. We analyzed the dosimetric differences of plans in the treatment planning system (TPS) between IMRT and VMAT in treating breast cancer. The aim of this study is to compare the dosimetric aspects of IMRT plans
with VMAT according to EMAMI, QUANTEC, and RTOG protocols
Awareness towards Dental and Oral Health among Parents of Children Undergoing Anti-Cancer Treatment
The study aimed to assess the attitudes toward dental and oral health of parents of children receiving anti-cancer
treatment. Methods: This cross-sectional descriptive study was based on a convenience sample of parents of 50 pediatric patients who
were receiving anti-cancer treatment (study group) and 62 parents of healthy children (control group). Questionnaires were
distributed to assess awareness towards oral and dental care.
Study to Find Clinical Characteristics of ABPA in Patients of Severe Bronchial Asthma and Its Relation with Serum Ige Level at Teriary Care Center North India
Allergic bronchopulmonary aspergillosis (ABPA) is an idiopathic inflammatory disease of the lung, characterized by an allergic inflammatory response to colonization of the airways by Aspergillus fumigatus or other fungi. Untreated
or inadequatetreatment may lead to poor outcome in patients. Raised level of serum IgE of more than 1000 IU/ML have
been considered as one if theimportant diagnostic criteria for ABPA, however relation of serum IgE withs severity ofdiseases is lacking. This study was conducted to find out level of serum IgE in patients ofABPA and to find out corelation of
Serum IgE with duration of symptoms and diseasesseverity.
Successfully Treatment of Dental Fluorosis using the Simple Technique of Enamel Microabrasion
Dental dyschromias have several origins among them we cite fluorosis. Dental fluorosis is defined as a qualitative anomaly of the enamel, resulting histologically in hypomineralisation due to excessive ingestion of fluorides during amelogenesis. Clinically, it takes the form of opacities in the enamel. These opacities may affect homologous teeth symmetrically, and generally affect several groups of teeth. Topographically, isolated or confluent white lines or discrete white patches are observed. Interpretismatic spaces are wider, resulting in porous and permeable enamel. On the one hand, this explains the post-eruptive dyschromias, where exogenous pigments penetrate the pores and transform the white opacities into brown. It is classified into 3 categories: mild, moderate and severe. So that this case was moderate fluorosis and appropriated for the treatment with enamel microabrasion. Differential diagnosis for this condition includes: enamel hypoplasia, amoelogenesis imperfecta, and dental caries.
Increasing CD8+ T Cells and Pro-Inflammatory Cytokines is associated with Hypersensitivity Reactions in People Living with HIV-1 under Antiretroviral Treatment
Background: Despite their good efficacy, antiretroviral drugs often induce adverse effects, in particular hypersensitivity reactions (HSR) which cause significant discomfort leading to the abandonment of treatment and then to therapeutic failure in some HIV-positive patients. Therefore, in this study, we aimed to assess the association between immune responses and
hypersensitivity reactions (HSR) induced by antiretroviral treatment in people who living with HIV-1 (PLHIV-1), through the distribution of immune cells and cytokine profiles.
Evaluation of a Theory-Based Behavior Change Intervention to Increase HIV Self-Testing Uptake and Linkage to HIV Prevention, Care, and Treatment Among Hard-to-Reach Populations in Northern Tanzania
Introduction: Tanzania aims for 95% of persons living with HIV (PLHIV) to know their serostatus by 2023.
Methods: An uncontrolled before-after study design was conducted between March 2018 (pre-intervention phase) and July 2018 (post-intervention phase). A total of 183 participants (males=89; females=94) were recruited for this study. Data were collected at baseline and at the one-month and three-month follow-ups using a pre-and post-test semi-structured questionnaire. Descriptive data are presented using measures of central tendency and their respective measures of dispersion. No comparative statistical analysis was performed.
Treatment of pulp and paper mill effluent by the coagulation-flocculation process
Tunisian mill wastewater analyzed for the first time prove high Chemical Oxygen Demand (COD) and high Turbidity values and deserve treatment. The biodegradability index determined by the biochemical oxygen demand (BOD)/chemical oxygen demand (COD) ratio was only 0.072, suggesting its limited biodegradability. Primarily, settling tank showed a positive effect in COD values reduced from 2490 to 448.2 mg/L. In addition, turbidity was reduced from 140 to 65.8 NTU. The coagulation-flocculation process using chemical coagulants-flocculants prior treatment equilibrate this ratio in range 1-2 promises a feasible biological treatment
The Role of Complementary and Alternative Medicine in the Treatment of Insomnia
Insomnia is a frequent condition that can be acute, intermittent, or chronic. It is an unpleasant feeling that makes it difficult to fall asleep. The main aim of the review is to determine the adverse effects of Insomnia drugs and the need to opt for Complementary and alternative medicine (CAM) approach as an adjuvant in treating Insomnia condition with lesser- known side effects. The Methodology involved a detailed literature survey which was performed through an online database, such as Science Direct, Google Scholar, Scopus, Cochrane, and PubMed. The study included original research and book chapters conducted on relation with Insomnia in particular with various therapies used currently and aimed to find possible alternative source which will be effective in treatment as well as with less burden of side effects
Anti-Infectives do not Impact Treatment Response to Immune Checkpoint Inhibitors: a Single Center Retrospective Analysis
Immune-checkpoint inhibitors (ICI) have provided groundbreaking advancements for a
variety of malignancies. It has been of recent interest to identify predictive indicators of response to improve cancer
management using immunotherapy. The intestinal microbiome has been recognized as a potential predictor of ICI anti-
tumor activity. Antibiotics reduce diversity the overall composition of the gut microbiota, with effects seen as quickly as in
a single day. Post-antibiotic dysbiosis recovery varies depending on type and duration of exposure. Preclinical studies in
mice with advanced cancer treated with broad spectrum antibiotics have been associated with resistance to ICI treatment.
Machine Learning Prediction of Response towards Anti-VEGF Injections in Patients with DME: Prediction of Post-Injection CST
Diabetic macular edema (DME) has become one of the most potential complications that results in loss of vision in patients with
diabetic retinopathy. Treatment outcomes that have been predicted directly with advent of machine learning (ML) methods after
the initial anti-vascular endothelial growth factor (anti-VEGF) injection, has become extremely vital in the management of DME.
Purpose: The aim of this study is to analyze the efficiency of the ML regression models which were developed and validated to predict the possible post-injection central subfield thickness (CST) value and distant vision best corrected visual acuity (DV BCVA)
in eyes with DME before the anti-VEGF injection is administered at either treatment initiation or during treatment monitoring.
Methods: This retrospective study was conducted in Medical Research Foundation, Chennai, India from January 2010 to
December 2020. The model development emphasized on an ensemble ML system consisting of four ML models that were
developed and trained independently using the clinical parameters to predict the post injection CST value. The dataset
consisting of 906 patients with total of 1874 samples [Optical coherence tomography (OCT) images and clinical parameters] were divided into trained and test set, and the model was validated on test dataset. The predicted CST values was then
compared against the respective sample’s post injection actual CST value. The comparative results were measured in terms
of Correlation Coefficient and Mean Absolute Relative Error (MARE).
Results: On evaluation, we found that Support Vector Regression (SVR) with linear kernel performed best among the
other models with four different scenarios in term of both CST and DVBCVA prediction with correlation coefficient of
0.65, 0.73, 0.75, 0.85 and 0.83, 0.87, 0.89 and 0.92 respectively.
Factors Influencing Adherence to Hydroxyurea Treatment Among Children with Sickle Cell Disease at the Mother and Child Center of the Chantal Biya Foundation
Introduction: Sickle cell disease (SCD) is a genetic hemoglobin disease for which there are many treatment options. Evidence supports the efficacy and cost-effectiveness of hydroxyurea (HU). Nevertheless, its use and adherence to treatment remain suboptimal, hence, the necessity to assess the factors influencing this observance.
Objectives: The objective was to evaluate the factors influencing observance to HU in children with sickle cell disease from the Mother and Child Center of the Chantal Biya Foundation (MCC of the CBF).
Materials and Methods: This was a descriptive and analytical cross-sectional study from January to June 2020. Children on HU for at least six months, and followed up at MCC of the CBF were included. Data collection was done using a pre-tested questionnaire. The level of compliance was assessed using the Morisky’s observance grid, where 8 points was considered as “good”; 6-7 points as “fair”, and <6 as “poor”. Data were stored in CSPro version 7.0 software, and subsequently analyzed using the SPSS version 20.0 software.
Results: Of 142 patients recruited, the level of patient observance was considered “good” in 2.1%, fair in 26.1% and poor in 71.8%. Logistic regression analyses suggested that using hydroxyurea to prevent complications was the only factor that favored good medical adherence [OR=0.37; CI (0.14-0.987)] (p=0.047). Poor compliance was mainly associated with the fear of infertility and and other sides effects associated with the use of HU.
Conclusion: Children with SCD in this study have poor compliance with HU. Implementing IEC sessions would make it possible to raise patient/parent awareness and reverse this trend.
A Case of Rheumatoid Arthritis Presenting with A Brain Mass
Among patients with tuberculosis (TB), approximately 1 to 5 percent develop central nervous system (CNS) complications. A tuberculoma is a conglomerate granulomatous focus that develops from coalescing tubercles acquired during disseminated bacillaemia. Radiographically, tuberculomas are discrete, ring- enhancing lesions of the brain surrounded by perilesional edema and may present as single or multiple lesions. The diagnosis of tuberculoma should be suspected in patients with mass lesion of the brain and relevant epidemiologic factors. A definitive diagnosis of tuberculoma is established via needle biopsy of the CNS lesion for histopathology and acid-fast bacilli (AFB) staining and culture.
In this case report, we present a 43-year-old woman with a past medical history of rheumatoid arthritis (RA) managed with steroids and hydroxychloroquine, who attended to us with a two- month history of numbness and paresthesia of her left extremities and recurrent episodic jerks involving the same side. Brain magnetic resonance imaging (MRI) revealed a large hemorrhagic mass (55 * 40 mm) in right temporo-parietal lobe surrounded by edema and mass effect with small nodule in left peri Rolandic cortex. Following clinical and laboratory clues, MR spectroscopy and brain biopsy, we started with corticosteroids and the following 4 anti-TB drugs: Isoniazid, Rifampin, Pyrazinamide, Ethambutol (HRZE). After 2 months, her symptoms completely resolved and a subsequent MRI scan revealed considerable shrinkage of the right-sided mass and left-sided lesion.
Editorial Board Members Related to Treatment

E Işil Arslan Topal
Assistant Professor
Department of Environmental Engineering
Firat University
Turkey
Department of Environmental Engineering
Firat University
Turkey

VOJTECH HAINER
Associate Professor
Institute of Endocrinology
Obesity Management Center
Prague
Czech Republic
Institute of Endocrinology
Obesity Management Center
Prague
Czech Republic

RICHARD K. GILROY
Professor of Medicine
Medical Director of Liver Transplantation
Department of Gastroenterology and Hepatology
University of Kansas Medical Center
United States
Medical Director of Liver Transplantation
Department of Gastroenterology and Hepatology
University of Kansas Medical Center
United States

Jyotsna Sharman
Assistant Professor
Department of Health and Human Performance
Radford University
United States
Department of Health and Human Performance
Radford University
United States

Charles C. Muscoplat
Professor
Department of Food Science and Nutrition
University of Minnesota
United States
Department of Food Science and Nutrition
University of Minnesota
United States

GEORGE E. WOODY
Professor
Department of Psychiatry
University of Pennsylvania and Treatment Research Institute
United States
Department of Psychiatry
University of Pennsylvania and Treatment Research Institute
United States

Xiaoqing Guo
Division of Genetic and Molecular Toxicology
National Center for Toxicological Research (NCTR)
USA
National Center for Toxicological Research (NCTR)
USA