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Case Report: Pyoderma Gangrenosum in IBD Treated with Tofacitinib

Pyoderma gangrenosum is a rare ulcerating skin disease often presenting as an extra intestinal manifestation of IBD and is difficult to manage. Treatment options for pyoderma gangrenosum include steroids, calcineurin inhibitors and anti TNF agents. Here in, we report a case of recurrent Pyoderma gangrenosum with Ulcerative Colitis that was successfully managed with Tofacintib, a JAK inhibitor
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Forensic Examination of Heroin and Its Cutting Agents

In order to successfully counter the ever-growing drug problem, there is an increasing need, to identify conspiracy links and trafficking routes and to gather background intelligence concerning both the number of sources of drugs and whether those sources are within a country or are “internationally” based and also the points of distribution and distribution networks. A scientific tool to complement routine law enforcement investigative work in this field is the characterization and impurity profiling and cutting agents of seized drugs. Drug characterization studies have shown that it is possible to link samples, to classify material from different seizures into groups of related samples and to identify the origin of samples. Such information can be used for evidential (judicial, court) purposes or it can be used as a source of intelligence to identify samples that may have a common origin or history.
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Ayurvedic Antiviral Agents: Overview of Medicinal Plants Perspective

In recent years it has been reported that many of the herbal plants contain antiviral agents which combat human disease that are caused by pathogenic viruses. The natural products which are obtained from plants as antiviral agents against viruses have gone through researches to check the efficacy and potentials of the herbal products in prevention of viral disorders.
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Remineralization Activities of Bioactive Materials and Nanotechnological Products Used in Pediatric Dentistry

Tooth decay is a progressive disease caused by acid fermentation of carbohydrates by pathogenic microorganisms in the mouth, leading to demineralization of teeth.
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Recovery of DNA from Fingerprints on Enhanced Different Paper Types

Documents are commonly met in threats, kidnapping, and extortion at crime scenes. Perpetrators may handle papers, so that it may contain incriminating evidence
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Caenorhabditis elegans (C. elegans) Used as a Whole Model Organism to Identify New Anti-Infectives Therapeutic Agent for MRSA Pathogens - A Review Paper

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the greatest fears with the number of serious infections on human health regarding antibiotic resistance. It causes a wide range of infections and bacteremia, ranging from inconsequential superficial skin infections, wound suppuration, even pneumonia or deep-seated tissue infections, which may lead to sepsis and fatalities.
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New Resin Cements Agents in Conservative Dentistry: Indications and Possible Risks. Rev Literature

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Irrational Anti-Retroviral Therapy Prescription among Children Under 15 Years in Eastern Uganda

Highly Active Anti-Retroviral Therapy (HAART) has transformed HIV/AIDS into a manageable chronic illness with HIVinfected children having near-normal growth milestones as a result of virologic control and immunologic reconstitution.
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Isolation, Identification, and Characterization of the Novel Antibacterial Agent Methoxyphenyl-Oxime from Streptomyces pratensis QUBC97 Isolate

Streptomyces species are medically, industrially, and microbiologically important bacteria that are found in soils and other habitats. Streptomyces isolates and QUBC97 were cultured on a new medium (CCG). Agar plug diffusion test showed antibacterial activity. N-butanol extracts analysed by silica thin layer chromatography (TLC), HPLC purified and identified by MS analysis. QUBC97 was identified based on morphology, PCR, and DNA sequencing of two loci.
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Severe Bone Marrow Suppression Associated with Use of Clopidogrel

A 60 year-old male presented with fever, malaise, and myalgias. The patient was admitted 3 weeks prior for acute coronary syndrome, underwent coronary stent placement, and was started on clopidogrel.
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An Introduction to the Approaches of Novel Drug Delivery Systems for Acquired Immune Deficiency Syndrome (AIDS)

The currently available anti HIV agents have several drawbacks such as short half life, low bioavailability, poor CNS penetration and retention, hepatic first pass metabolism, undesirable side effects and frequent dosing regimen.
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Effects of Oxytocin and Carbetocin on Haemostatic Variables in Pregnant Women after Cesarean Section

Uterine atony is the first cause of haemorrhage at delivery. To prevent post partum major bleeding uterotonic prophylactic drugs are commonly used after caesarean section. Few studies showed an haemostatic activation after oxytocin infusion while no data are available on carbetocin.
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Orally Disintegrating Tablets: A Short Review

This article summarizes the advantages of orally disintegrating tablets (ODTs) as well as critical issues during evaluation of ODTs such as bioequivalence and challenges and limitations of ODTs and finally present and the future of ODTs. ODTs have received everincreasing demand and the field has become a rapidly growing area in the pharmaceutical industry.
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Nanotechnology Approaches for Antiretroviral Drugs Delivery

The development of effective drug delivery approaches for the treatment of AIDS and HIV infection is a global challenge. The advent of multidrug, highly active antiretroviral therapy (HAART), have increased the life span of HIV-infected patients.
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Phase II Trial of Lower Dose Bevacizumab and Irinotecan in Relapsed High Grade Gliomas

Relapsed high-grade gliomas (HGG) respond poorly to known chemotherapeutic agents with a median survival of 3 to 6 months. Several phase II trials of Bevacizumab for salvage therapy, reported excellent response rates. The optimal dose of Bevacizumab in GBM has not been defined to date. We performed a prospective phase II trial of bevacizumab using 5 mg/kg every 2 weeks.
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Editorial Board Members Related to agents

Jack Ho Wong

School of Biomedical Sciences
Chinese University of Hong Kong
Hong Kong

Vincenzo Cuomo

Professor
Department of Physiology and Pharmacology
Sapienza University of Rome
Italy

Zafar K. Khan

Professor
Department of Microbiology and Immunology
Drexel University
United States

Vincenzo Cuomo

Professor
Department of Pharmacology
University of Rome
Italy

Cecilia Young

Consultant Physician Pharmacist People Health Magazine
Hong Kong

Vladimir W. Spolsky

Associate Professor
Division of Public Health & Community Dentistry
School of Dentistry
University of California
United States

Suresh G. Joshi

Associate Professor
Department of Microbiology and Immunology
Drexel University
United States

Emmanuel O. Akala

Professor
Department of Pharmaceutics
Howard University Institutional Animal Care
United States

LUIS CLAUDIO NASCIMENTO DA SILVA

Department of Parasitary Biology
Ceuma University
Rua dos Castanheiros Jardim Renascença 65075120 - São Luís
Brazil

MD Ibrahim El Said Ali El-Gamal

Assistant Professor
College of Pharmacy
Department of Medicinal Chemistry
University of Sharjah
UAE
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