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Articles Related to disease

Unlocking Neurodegeneration: Scaffold-Derived Blockers of MAO-B and AChE Inspired by Bryophyllum pinnatum: A Structural Exploration

This study evaluates the potential of Bryophyllum pinnatum ligands as treatments for Alzheimer's disease (AD) and Parkinson's disease (PD) by targeting acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), enzymes linked to these neurodegenerative disorders. Utilizing Schrödinger Suite and Maestro 12.8 for computer-aided drug design, ligands from B. pinnatum and standard drugs were docked into the active sites of AChE and MAO-B. Further analysis included ADMET screening and MM/GBSA calculations, with pharmacophore modeling to align compounds with reference ligands. The study identified 4 and 6 promising compounds as MAO-B and AChE inhibitors, respectively. Pinoresinol was identified as the most promising candidate, exhibiting optimal binding, favorable blood-brain barrier permeability, and pharmacophoric features similar to those of the standard drug. These findings suggest the neuroprotective capabilities of B. pinnatum ligands, recommending further in vivo and in vitro testing to confirm their therapeutic efficacy
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Maintenance Hemodialysis Exacerbate Aluminum and Arsenic Toxicity in Chronic Kidney Disease Patient

Maintenance hemodialysis (MHD) is the most effective interventional therapy for patients with chronic kidney disease (CKD). Our aim was to investigate the serum levels of aluminum (Al) and arsenic (As) in CKD patients. Methods: A total of 29 CKD patients receiving MHD were surveyed for selected biochemical, and dialysis quality indices. Serum Al and As levels were measured before and after MHD. Statistical analyses included independent samples t-test or Mann-Whitney, Kaplan-Meier, Pearson, or Spearman's rho correlations
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Bioactivity of Plant Extracts Against Fusarium Oxysporum f. sp. Lycopersici Sacc.) Causing Wilt Disease of Tomato (Solanum Lycopersicum L) in the Southern Guinea Savannah, Nigeria

Wilt disease of tomato is caused by Fusarium oxysporum f. sp. lycopersici and it is an important disease which causes significant yield reduction in the crop throughout the world. A study was undertaken to isolate, identify and test the pathogenicity of F. oxysporum f. sp. Lycopersici on tomato; and to evaluate the bioactivity of Azadirachta indica leaf, Piper guineense seed and Zingiber officinale rhizome extracts as well as the synthetic fungicide, mancozeb at different concentrations and combinations for the management of F. oxysporum f. sp. lycopersici in vitro. Results revealed that the percentage frequency of the fungus isolated and identified was more on the roots (35.56 %) than the stems (26.67 %), fruits (20.00 %) and leaves (17.77 %). Results of the pathogenicity test showed more virulence in the roots than in other parts of the tomato plant. Extracts of the three plants and mancozeb proved effective in controlling the mycelial growth of the fungus either alone or when combined. Mancozeb consistently gave 100 % growth inhibition irrespective of the concentration used. Among the plant extracts applied alone at 40 g/L, Z. officinale (66.69 %) was the most effective followed by P. guineense (53.52 %) while A. indica was the least (36.99 %). The mycelial growth inhibition increased from 40 g/L to 120 g/L irrespective of the combination of the treatments used. A combination of mancozeb with any plant extract was more effective than a combination of the plant extracts. It is therefore, recommended that the plant extracts be applied either alone or in combination with other plant extracts or the fungicide to control F. oxysporum f. sp. lycopersici, increase tomato yield and reduce postharvest rots associated with the pathogen
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Approach to and Management of a Adynamic Bone Disease in Hemodialysis Patients-A Review

Chronic kidney disease (CKD) is now a global public health epidemic with increasing rates reported all over the world. Currently, more than 850 million people are estimated to live with CKD worldwide. Bone and mineral disorders (CKD-MBD) form an integral part of the management of CKD patients. CKD-MBD encompasses distinct abnormal pathology within the spectrum of Renal Osteodystrophy (ROD), including osteitis fibrosa cystica, osteomalacia, adynamic bone disease (ABD), mixed lesions, and osteoporosis. ABD is primarily characterized by decreased or absent bone formations along with low cellularity of both osteoblasts and osteoclasts as well as thin osteoid seams and minimal or absent peri trabecular/marrow fibrosis. ADB is also associated with a greater risk of vascular calcification and fractures negatively affecting patient outcomes. It is unclear if all forms of ABD are truly pathological or milder forms of ADB could be a compensatory mechanism to guard against bone loss. In this article, we describe a hemodialysis patient profile of ADB with a review of this entity
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The cause of Alzheimer's Disease & Relative Dementias is Brain Information Processing Impairments

In the last decade, neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease, and various forms of Dementia) have become a challenging problem facing contemporary society, placing on it a strong economic, social, and healthcare burden. Despite huge and long-lasting efforts, the progress in solving these problems remains unsatisfactory
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Transgenic Expression of Sugarcane Mosaic Virus VPg in Maize Inbred Line CML444 Confers Resistance to Maize Lethal Necrosis Disease

Maize is the most important crop in Kenya and parts of Sub-Saharan Africa. However, yields are below potential due to abiotic and biotic constraints. One of the major biotic concerns is maize lethal necrosis disease (MLN), which causes up to 100% yield losses. MLN is caused by the synergistic infection of two viruses, Maize chlorotic mottle virus (MCMV) and a potyvirus, commonly Sugarcane mosaic virus (SCMV)
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A Single-Center Experience in Alport Syndrome

Alport Syndrome is a hereditary condition that affects the collagen in the basement membrane and is characterized by microscopic hematuria, sensorineural hearing loss, increasing renal dysfunction, and ocular abnormalities. It is more common between the ages of 20 and 30. Men and women are equally affected. However, the prognosis of men is worse than women due to renal failure. The purpose of this study is to evaluate the demographic and clinical findings of patients with Alport Syndrome in our center
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The Challenge of Rapid Data Collection and Health Promotion: A Quick and Easy Approach

Rapid data collection can provide an insight into causation, the socio-cultural reality, and complex social processes. This is especially important in disease outbreaks when information is quickly required on local needs that is essential for success. Quantitative data alone are not sufficient to provide an in-depth understanding. The challenge is to use a rapid data collection approach that can provide practical solutions by integrating the available evidence, professional expertise, and stakeholder experiences. This viewpoint reflects the opinions of the author that highlight the strengths and weaknesses of rapid data collection and the presentation of an approach that can be implemented with minimal interference in a health promotion and healthcare program context
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Case Report: Pyoderma Gangrenosum in IBD Treated with Tofacitinib

Pyoderma gangrenosum is a rare ulcerating skin disease often presenting as an extra intestinal manifestation of IBD and is difficult to manage. Treatment options for pyoderma gangrenosum include steroids, calcineurin inhibitors and anti TNF agents. Here in, we report a case of recurrent Pyoderma gangrenosum with Ulcerative Colitis that was successfully managed with Tofacintib, a JAK inhibitor
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Effect of Pesticides on Human Health

The demand for pesticides has increased in today's world of expanding population in order to boost crop productivity and eliminate undesirable plants (weeds) that grow alongside the primary crop.
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Study to Find Clinical Characteristics of ABPA in Patients of Severe Bronchial Asthma and Its Relation with Serum Ige Level at Teriary Care Center North India

Allergic bronchopulmonary aspergillosis (ABPA) is an idiopathic inflammatory disease of the lung, characterized by an allergic inflammatory response to colonization of the airways by Aspergillus fumigatus or other fungi. Untreated or inadequatetreatment may lead to poor outcome in patients. Raised level of serum IgE of more than 1000 IU/ML have been considered as one if theimportant diagnostic criteria for ABPA, however relation of serum IgE withs severity ofdiseases is lacking. This study was conducted to find out level of serum IgE in patients ofABPA and to find out corelation of Serum IgE with duration of symptoms and diseasesseverity.
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Review on MALDI TOF MS: Modern Disease Diagnosis Approaches in Microbiology and its Mechanism

Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) has become a widely used technique for the rapid, accurate, durable, economical, and trustworthy method for identification of bacteria, mycobacteria and fungal pathogens in the microbiology laboratory.
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Right Atrial Myxoma with Critical Triple Vessel Disease: A Case Report

Cardiac myxoma are the most common primary heart tumor. It accounts for 40-50% of primary cardiac tumor. Approximately 75% occurs in left atrium and 15-20% in right atrium. Myxoma are usually polypoid, pedunculated lesion with smooth surface covered with thrombus. Most common site of attachment is at the border of fossa ovalis in left atrium but it can occur in any part of atrial wall. Symptoms are produced because of mechanical obstruction with cardiac blood flow, tumor embolization and constitutional symptoms due to increased expressions of IL-6. Echocardiography is the best diagnostic modality to localise the tumor. Surgical excision is the mainstay of treatment of myxoma present in any location.
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Mathematical Modeling of Pathological Processes in Alzherimer’s Disease

Using kinetic differential equations and the Runge-Kutt algorithm, an analysis of the pathological processes occurring in the course of Alzherimer’s disease was carried out. Thanks to the appropriately selected kinetic equations, the presented model allows to explain the time course of the growth of pathological proteins: beta-amyloid and tau protein and the related loss of nerve cells. The model is based on previous experimental knowledge of Alzherimer’s diseas and is in good agreement with the experimental data.
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A Case Report of ST-Segment Elevation Myocardial Infarction With Non-Obstructive Coronary Artery Disease: an Economical and Beneficial Investigative Algorithm

Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a puzzling clinical entity, coupled with potential multiple pathophysiological mechanisms, often makes disease classification, investigation and management difficult. Despite presence of myocardial damage and increased risk for the future, many patients are discharged undiagnosed, thus the specific cause is not effectively treated.
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Electronic-nose Applications in Forensic Science and for Analysis of Volatile Biomarkers in the Human Breath

The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.
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Editorial Board Members Related to disease

Marc Poirot

Research Director at INSERM
Cancer Research Center of Toulouse
University of Toulouse
France

CHRISTOPHER THOMAS WHITLOW

Associate Professor of Division of Radiologic Sciences
Department of Radiology
Wake Forest School of Medicine
United States

PERNG GUEY CHUEN

Associate Professor
Department of Microbiology and Immunology
National Cheng Kung University
Taiwan

CHIA-YI KUAN

Associate Professor
Department of Pediatrics
Center for Neurodegenerative Disease
Emory University School of Medicine
United States

Lihua Song

Associate Professor
Chief, Laboratory of Rickettsiology
Beijing Institute of Microbiology and Epidemiology
China

Chin-Chuan Wei

Associate Professor
Department of Chemistry
Southern Illinois University
United States

Jonathan Todd Carter

Associate Professor
Department of Surgery
University of California
United States

INTAN HAKIMAH ISMAIL

Associate Professor
Department of Paediatrics
Faculty of Medicine and Health Sciences (FMHS)
University Putra Malaysia
Malaysia

Wen-Quan Zou

Associate Professor
Departments of Pathology and Neurology
Case Western Reserve University School of Medicine
United States

Lan-Juan (Jean) Zhao

Assistant Professor
Department of Biostatistics and Bioinformatics
Tulane University
United States
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