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Articles Related to efficacy

A Brief Report on the Safety and Efficacy of Gentian Violet for Infant Oropharyngeal Candidiasis (OPC) and Maternal Nipple Candidiasis

Gentian violet dye is no longer commonly used for infant oropharyngeal candidiasis (OPC) and maternal nipple candidiasis, largely due to safety concerns, the emergence of modern treatment options, and lack of clarity on dosing. Current treatments for candidiasis include nystatin, azoles such as ketoconazole and fluconazole, and amphotericin B. However, OPC may resist treatment, and mothers may prefer gentian violet as an alternative OTC product. This literature review aims to assess the safety and efficacy of gentian violet in treating OPC and nipple candidiasis. Two search strings in Embase yielded 22 primary research articles, case reports, and commentaries. In terms of efficacy, gentian violet is as effective as standard of care treatments, and functions as a fungicidal agent against Candida albicans through biofilm manipulation. Safety concerns include skin and mucosal membrane irritation, airway obstruction, and, most concerning to regulatory agencies, animal carcinogenicity. However, the literature found that there was great variation in the dose and strength of gentian violet applied. Case reports with adverse events usually used high strengths of gentian violet applied more frequently than recommended. A lower strength of gentian violet solution applied as needed is less likely to result in adverse events. Patients may self-select higher strengths of gentian violet or apply more frequently than recommended. If recommended for treatment-resistant OPC and nipple candidiasis, counseling should accompany OTC use of gentian violet
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Innovative Method for Treating Diabetes: Cancer Medicines Show Great Possibility in Treating Type-1 Diabetes

Australian scientists have recently uncovered a groundbreaking discovery suggesting that diabetes, specifically type 1 diabetes, may be effectively treated using existing cancer drugs. The research indicates that two types of drugs commonly employed in cancer treatments have demonstrated the potential to prevent type 1 diabetes, with the remarkable capability of inducing insulin hormone production within the pancreas in as little as 48 hours. The experimental validation of this approach involved a successful trial conducted on three individuals, providing encouraging results that could revolutionize diabetes treatment. With more than 420 million people worldwide grappling with diabetes, this discovery holds significant promise for addressing a global health challenge. Further research and clinical trials are warranted to explore the full potential and safety of these cancer drugs as a potential cure for diabetes. If successful, this innovative approach may offer new hope to millions living with diabetes and pave the way for transformative advancements in diabetes care
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Maintenance Hemodialysis Exacerbate Aluminum and Arsenic Toxicity in Chronic Kidney Disease Patient

Maintenance hemodialysis (MHD) is the most effective interventional therapy for patients with chronic kidney disease (CKD). Our aim was to investigate the serum levels of aluminum (Al) and arsenic (As) in CKD patients. Methods: A total of 29 CKD patients receiving MHD were surveyed for selected biochemical, and dialysis quality indices. Serum Al and As levels were measured before and after MHD. Statistical analyses included independent samples t-test or Mann-Whitney, Kaplan-Meier, Pearson, or Spearman's rho correlations
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Efficacy of Standardized Ginger Extract in Subjects with Occasional Constipation: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study

Occasional constipation is associated with infrequent bowel movement and difficulty in passing stools without any obvious symptoms. Ginger has been used traditionally to manage various gastric conditions like constipation, dyspepsia, belching, bloating, epigastric discomfort, indigestion, nausea, and vomiting. The current study evaluated the effects of a standardized Ginger extract (GE) on objective and subjective markers of occasional constipation in a randomized, double-blind, parallel, placebo-controlled design
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To Evaluate the Efficacy of Ultrasound Guided Distraction Osteogenesis by Evaluating Qualitative Estimation of Bone Fill at Regeneration site and Management of Severe Mandibular Hypoplasia Secondary to Obstructive Sleep Apnoea: A Case Report

Distraction Osteogenesis (DO) is an established method for correction of developmental anomaly of the facial skeleton. The early beginning of urgent surgical corrections are allowed in smaller age as even small children suffering from bilateral severe mandibular deficiency who are often associated with breathing and swallowing disorder caused by glossoptosis.
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Factors Affecting Exercise Self-efficacy in Predialysis Chronic Kidney Disease Patients

There was significant evidence to suggest that exercise improves physical function, symptom burden, and quality of life in predialysis chronic kidney disease (CKD) patients. However, most CKD patients cannot adherence to minimum recommended levels of exercise.
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Epidemiology and Multidrug Resistance of Strongyle Nematodes in Ordos Finewool Sheep

Regular whole-flock treatments and long-term repeated use of similar anthelmintics has led to the development of anthelmintic resistance and widespread epidemic of sheep nematodiasis. The current work was carried out to understand the prevalence of gastrointestinal nematodes in Ordos fine-wool sheep and to evaluate the efficacy of currently used anthelmintics.
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Photodegradation, Antibacterial & Antioxidant Assessment of Multifunctional Zinc Oxide Metal Nanoparticles Using Smilax aspera Leaf Extract: An Eco Approach

The endeavor of this research accounts for a superficial green route scheme by using an extract of leaves of Smilax aspera as a stabilizing and capping agent. Zinc Oxide nanoparticles (ZnO-NPs) were examined through UV-visible Spectrophotometer, X-Ray Diffraction (XRD), EDX (Energy Dispersive X-rays spectroscopy), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM). The NPs demonstrates potential photo catalytic activity for the degradation of Methyl Orange (MO) and Methylene Blue (MB) dyes upon exposure to sunlight.
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Efficacy of Chemical and Organic Fungicides against Spot Blotch Management of Wheat

Spot blotch of wheat caused by Bipolaris sorokiniana is a problematic biotic constraint that causes 15-80% yield abatement in the Indian subcontinent and other parts of the world
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A Novel Neuroprotective and Antioxidative Efficacy of a Unique Combination of Standardized Huperzia serrata, Convolvulus pluricaulis and Celastrus paniculatus Extracts

Physical and environmental stress in conjunction with hectic lifestyle and unhealthy food habits are the major cause of diverse neurodegenerative disorders. Oxidative neuronal injury and acetylcholine deficiency have a major impact on learning and memory retention. Most of the treatment strategies are based on the improvement of cholinergic function in the brain and one of the emerging therapeutic targets is to enhance the acetylcholine level in the brain. Standardized botanical extracts including Huperzia serrata (1% Huperzine A, CogniUp), Convolvulus pluricaulis (SP) and Celastrus paniculatus (JY) have been demonstrated to attenuate brain function by serving as a natural acetylcholinesterase (AChE) inhibitor.
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Clinical Study on the Efficacy of Vipadikahara Grita Taila on the Treatment of Vipadika Skin Disease

Ayurveda has discussed all skin diseases under the name of Kushtha, and in other words it can be known as “Ayurveda Dermatology”. Eighteen types of these skin diseases are mainly divided into seven types of Maha Kushtha and eleven types of Kshudra Kushtha. Vipadika skin disease is diagnosed with the help of critical and analytical study of the literature in original Sanskrit texts and later clinical trial was carried out. In the present study, efficacy of Vipadikahara grita taila was assessed against Vipadika skin disease.
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Efficacy of Purified Glutathione -S- Transferee in Providing Protection against Haemonchus Contortus Infection in Sheep

The efficacy of purified glutathione-s-transferase (GST) to protect sheep against haemonchosis was assessed. Fifteen lambs, 3.5-5month-old, were bisected into five groups (n=3). Two groups were vaccinated with 250μg of each prepared antigen (crude adult antigen (CAA), purified GST) in combination with mineral oil adjuvant at zero, 14th days of the experiment. The other three groups were kept as control groups; non-immunized infected, non-immunized non-infected and adjuvant control. One week after the last booster dose, the lambs in all groups except control negative were challenged with 400 L3/kg live weight orally. Protein characterization of each antigen was done by SDS-PAGE and immunoblting. The vaccine efficacy was estimated by the fecal egg count, where the vaccinated groups showed 58.90% and 79.38% reduction in eggs in CAA and GST respectively. Moreover, 31.45% and 92.10% reduction in abomasal worm count was reported in CAA and GST vaccinated lambs, respectively. The protection was found corresponsive to the sera antibody levels in the immunized groups. It was concluded that the GST had protective efficacy against H. contortus infection in lambs.
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Artisanal Cannabis in Young and Adults Patients with Treatment Resistant Epilepsy: Prospective, Observational, Open-Label Study in Argentina

Background: A third of patients with epilepsy have a drug-resistant form. We aimed to observed whether addition of artisanal cannabis to existing anti-epileptic treatment would be safe, and efficacious in young and adults with drug-resistant epilepsy. Methods: Patients (aged 12-51 years) with severe, intractable epilepsy, who were receiving stable doses of antiepileptic drugs before study entry, were enrolled in an expanded-access programme at our epilepsy centre.
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Efficacy of Chitosan as Vaccine Adjuvant Against Paracoccidioidomycosis in Mice

Paracoccidioidomycosis (PCM) is a systemic disease caused by thermo- dimorphic fungi of Paracoccidioides genus that is endemic in several Latin American countries. The treatment for this disease can be performed with different drugs. In general, it is a long duration treatment that aims the control of the clinical manifestations. Even after treatment, the patient usually shows relapse and incapacitating sequelae, such as fibrosis and pulmonary emphysema.
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Efficacy and Safety of Moxifloxacin-Enhanced versus Standard Sequential Eradication Therapy for Treating Helicobacter pylori Infection among Tobacco Smokers

The therapeutic failure rate of eradication therapy for Helicobacter pylori (Hp) is increasing due to bacterial resistance; tobacco smoking can increase such a rate even more. We explored the role of adding moxifloxacin to the standard sequential eradication therapy for Hp in decreasing the therapeutic failure rate among the tobacco smokers.
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Editorial Board Members Related to efficacy

VANA SPOULOU

Associate Professor
Department of Paediatrics
University of Athens Medical School
Greece

Alex Kojo Anderson

Associate Professor
Department of Foods and Nutrition
University of Georgia
United States

Jacque Nyenhuis

Assistant Professor
Nutrition and Exercise Sciences
St. Catherine University
United States

Yanyan Li

Assistant Professor
Department of Health and Nutrition Sciences
Montclair State University
United States

Richard W. Bianco

Associate Professor
Department of Surgery
University of Minnesota
United States

CARMEN CASTANEDA SCEPPA

Associate Professor
Department of Health Sciences
Bouvé College of Health Sciences
Northeastern University
United States

Avinash Shankar

Chairman
National Institute of Health & Research
Warisaliganj (Nawada), Bihar
India

Tao Liu

Children's Cancer Institute
University of New South Wales
Australia
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