Articles Related to inflammation
Does Body Mass Index Influence the Onset and Prognosis of Colorectal Cancer?
Overweight and obesity are considered an increasing colorectal cancer risk factor. The association between excess body weight and colorectal cancer appears to be related to a state of systemic low-grade inflammation, due to an overproduction of proinflammatory cytokines.
Citrus Jabara Juice Diminishes Allergic Airway Inflammation in an Ovalbumin (OVA)-Induced Murine Asthma Model
Citrus jabara is a type of citrus fruit originally grown in Kitayama-Mura in Wakayama, Japan, and is reputed to have anti-allergic properties. In this study, we tested whether citrus jabara juice inhibits inflammatory mediators in a mouse allergic asthma model.
The Simultaneous Activation of Nrf2 and Antioxidant Compounds may reduce the Risk, Progression, and Improve the Management of Diabetes by Reducing Oxidative and Inflammatory Damages
Despite extensive research, the incidence of diabetes continues to increase, and the management of diabetes needs improvement, because in 2016, more than 100,000 patients had lower extremity amputated, suffered ischemic heart disease and stroke. Analysis of investigations indicates that increased oxidative stress and chronic inflammation enhance the risk, progression, diabetic–related complications, and reduce effectiveness of drug therapy. Therefore, simultaneously attenuation of these cellular abnormalities may help in reducing the risk of development, progression, and prolonging the effectiveness of drug therapy.
A Controlled Release PLGA Bupivacaine Construct and its Effect on Chondrocytes
Controlling osteoarthritic pain has emerged as a major health care challenge. Available treatments are either cytotoxic or addictive and therefore there is an urgent need to develop alternative treatment options. We previously developed a liposomal-alginate construct to improve local anesthetic delivery as a potential chronic pain management treatment.
Impact of Inflammation on Atrial Fibrillation in patients with Metabolic Syndrome
Inflammation has been involved in the pathogenesis of both metabolic syndrome (MS) and atrial fibrillation (AF). The magnitude of elevations in plasma C-reactive protein (CRP) a marker of inflammation is probably related to atrial structural remodeling and impaired atrial function. In patient with MS, limited data exist regarding impact of plasma levels
of inflammatory markers, such as C-reactive protein on the: type of AF and atrial structural and functional remodeling.
Fractional Exhaled Nitric Oxide (FeNO) in Healthy Obese Adults
It was a cross-sectional study including 434 apparently healthy subjects (194 males) divided into two groups: i) obese (BMI ≥ 30 Kg/m²) and ii) non-obese (BMI < 30 Kg/m²). Exclusion criteria were: current smokers, asthma, medicine intake interfering with FeNO levels, and abnormal lung function tests. The FeNO measurements were performed before spirometry. Student t test was performed to compare between the two groups. The Spearman correlation between BMI and FeNO levels was evaluated. The Piecewise linear regression with breakpoint was assessed to define the breakpoint of inflammation related to obesity.
Review of the Diagnostic Value of Ultrasound Imaging in Giant Cell Arteritis
Giant cell arteritis (GCA) requires prompt diagnosis as clinical indicators of GCA are non-specific. Temporal artery biopsy (TAB) can be inconclusive and difficult to arrange timely. MR imaging is accurate for showing vessel thickening. However, the availability of MRI remains an issue in many radiology departments.
Periodontal Maintenance Therapy and Generalized Aggressive Periodontitis: Brief Review of the Literature and Case Report
This case report presents an unusual variant of generalized aggressive periodontitis that was managed by nonsurgical therapy which included the use of a novel tooth gel. Also, a brief review of the literature is offered as context for this unusual clinical case. The patient, a 40-year old Caucasian female, presented with advanced bone loss involving all teeth, intense inflammation of the attached gingiva and little obvious supra- or subgingival biofilm and dental calculus. Presence of systemic disease, high levels of periodontal microbial pathogens and IL-1α and IL-1β polymorphisms were evaluated and all determined to be negative. Gingival biopsy resulted in a diagnosis of nonspecific inflammation. Treatment consisted of 2- and 3-month intervals for periodontal maintenance appointments and eventually the introduction of an activated edathamil-based tooth gel. Over the subsequent 4-years the patient’s periodontal status stabilized as manifested by no further loss of tooth supporting bone, a reduction in the percentage of periodontal pockets of 4-6 mm depth and a reduction in the percentage of sites exhibiting bleeding upon periodontal probing. The significance of this case report is to emphasize that, even in cases of severe generalized aggressive periodontitis, nonsurgical periodontal therapy can be effective. In addition, it appears that a novel tooth gel containing activated edathamil is effective at reducing gingival inflammation with a concomitant reduction in percent of sites that bleed on periodontal probing.
The ACAI (Euterpe oleracea Mart.) Pulp Consumption Improves Blood Pressure Levels in Women with Higher Concentrations of Interferon-Gamma
Interferon-gamma (IFN-γ) is associated with the inflammatory responses modulation, which could culminate in chronic metabolic diseases. In this context, the aim of the present study was to evaluate the effect of the acai (Euterpe oleracea Mart. mart.) pulp consumption on the anthropometric, clinical and biochemical parameters in women clinically healthy, with IFN-γ, respectively, smaller and higher than 5 pg/mL. Twenty four women in G1 (with IFN-γ concentrations smaller than 5 pg/mL) and sixteen in G2 (with IFN-γ concentrations greater than 5 pg / mL), consumed 200g per day of acai pulp during four weeks. Anthropometric and body composition measurements, biochemical and clinical data were evaluated before and after the intervention
Compartmentalization Modules of Inflammatory Response are Centered on the Epithelial-Mesenchymal Transition of Transforming Cells in Carcinogenesis
The epithelial-mesenchymal transition (EMT) event in carcinogenesis is dependent on multiple operant pathways of master transcription as proposed for NF-kappaB and in terms of the initiated progression of malignant transformation. Inflammation is a primarily compartmentalized series of distinct and overlapping systems that induce and enhance multifocal operabilities within both the nucleus and cytoplasm by systems of enhancer/inhibitory modes of modulation of multi-gene transcription.
A Randomized Double-Blind Placebo Controlled Clinical Trial Evaluating the Effects of an Investigational Study Product on Exercise Induced Muscle Soreness, Markers of Inflammation, Muscle Damage and Exercise Performance in Healthy Males
Gherkin, a pure botanical extract from cucumber is a phytonutrient rich vegetable which may have been shown to have anti-inflammatory and pain relieving properties. The purpose of this randomized double-blind placebo study was to determine the effects of Gherkin (Cuvitus™, Actido®)on exercise performance, markers of inflammation and acute muscle soreness in healthy males.
Changes in Several Disease Parameters Including Abzymes and Hematopoietic Progenitor Colony Formation in Brain Inflammation and Demyelination
Demyelination induced by cuprizone-is a widely used experimental model to analyze processes of re- and demyelination in the central nervous system (CNS). Here we used C57BL/6 mice; a model of experimental autoimmune encephalomyelitis (EAE) mimicking important aspects of human multiple sclerosis, to evaluate effects of cuprizone-dependent demyelination on different parameters associated with autoimmune inflammation. The treatment of mice with cuprizone leads to a significant decrease of several indexes characterizing spontaneous and myelin oligodendrocyte glycoprotein (MOG35-55)
Jugular versus Mammary Vein Acid-Base Balance, Blood Gases, Hematobiochemical Profiles and Inflammation Biomarkers in Goats with Acute Mastitis
The objectives of this study was to investigate the acid-base balance, blood gases, hematobiochemical profiles and the inflammation biomarkers fibrinogen, serum amyloid A (SAA) and haptoglobin (Hp) in the mammary and jugular veins of goats with mastitis. Blood samples were collected from the jugular and mammary veins from 26 goats with mastitis and from 10 healthy lactating goats. In diseased goats, the affected quarter had a remarkable degree of swelling, hard and sore to touch; the milk was bloody. In the jugular vein of diseased goats, the values of PCO2, PO2, base excess (BE), HCO3 and TCO2 were significantly lower than in the jugular vein of controls.
Clinical Utility of Triglyceride: HDL-Cholesterol Ratio as a Surrogate Marker of Inflammation in Pediatric Obesity
The prognostic utility of the triglyceride: HDL-cholesterol (TG:HDL-C) ratio, a marker for insulin resistance, is unknown among high-risk children and adolescents. We examined the clinical utility of TG:HDL-C ratio as a marker of insulin resistance and chronic inflammation in obese youth.
Inguinal Lymph Node Squamous Cell Carcinoma of Unknown Primary Site: A Case Report
Carcinoma of unknown primary site (CUP) is a heterogeneous group of malignancies associated with dismal prognosis. Although majority
of the patients present with disseminated disease, some of them do present with disease limited to the lymph nodes.
Editorial Board Members Related to inflammation

Chi-Rei Wu
Associate Professor
Department of Chinese pharmaceutical sciences
China medical university
China
Department of Chinese pharmaceutical sciences
China medical university
China

Muzzafar Zaman
Assistant professor
Department of Surgery
Maharishi Markandeshwer Institute of Medical Sciences and Research
India
Department of Surgery
Maharishi Markandeshwer Institute of Medical Sciences and Research
India

WINNIE CHAN
Department of Nutrition & Dietetics
University Hospitals Birmingham NHS Foundation Trust
United Kingdom
University Hospitals Birmingham NHS Foundation Trust
United Kingdom

Marion A Hofmann Bowman
Assistant Professor
Department of Medicine
Section of Cardiology
University of Chicago
United States
Department of Medicine
Section of Cardiology
University of Chicago
United States

Chunying Li
Assistant Professor
Department of Biochemistry and Molecular Biology
Wayne State University School of Medicine
United States
Department of Biochemistry and Molecular Biology
Wayne State University School of Medicine
United States

Yi-Wen Liu
Professor
Department of M icrobiology, Immunology and Biopharmaceuticals
National Chiayi University
Taiwan
Department of M icrobiology, Immunology and Biopharmaceuticals
National Chiayi University
Taiwan