Articles Related to ions

This study was conducted to compare the bioavailability of two tablet formulations containing 200 mg Lacosamide (one Lacosamide 200 mg film-coated tablet marketed in Italy as Ollat®, one Vimpat® coated tablet). 20 healthy subjects were enrolled in a single-center, randomized, single-dose, laboratory-blinded, 2-period, 2-sequence, crossover study, with a minimum washout period of 7 days. All the 20 subjects completed the study. Plasma samples were collected up to 72.0 hours post-dosing. Lacosamide levels were determined using a validated high-performance liquid chromatography with tandem mass spectrometry (HPLC/MS/MS) method

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Pneumonia is most prevalent and acute respiratory disorder. Chest radiography is the gold standard to confirm the clinical condition and the progress. The use of AI in diagnostic workflow proved to be useful. In this study, quantitative assessment by the AI device is compared with the qualitative assessment by the radiologists.

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Respiratory Syncytial Virus is an etiological cause of lower respiratory tract infections. Due to the controversial therapeutic approach, it has a significant share in the causes of hospitalizations and even fatal outcomes concerning children up to two years of age. The elderly patients, especially the immune compromised and those with co-morbidities, are at a great risk of developing severe conditions because it is often not considered as pathogen. Those are the reasons which determine the necessity of prophylaxis of the abovementioned target groups of patients - children up to two years of age and adults over 65 years of age.

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Background: Despite their good efficacy, antiretroviral drugs often induce adverse effects, in particular hypersensitivity reactions (HSR) which cause significant discomfort leading to the abandonment of treatment and then to therapeutic failure in some HIV-positive patients. Therefore, in this study, we aimed to assess the association between immune responses and hypersensitivity reactions (HSR) induced by antiretroviral treatment in people who living with HIV-1 (PLHIV-1), through the distribution of immune cells and cytokine profiles.

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Introduction: Tanzania aims for 95% of persons living with HIV (PLHIV) to know their serostatus by 2023. Methods: An uncontrolled before-after study design was conducted between March 2018 (pre-intervention phase) and July 2018 (post-intervention phase). A total of 183 participants (males=89; females=94) were recruited for this study. Data were collected at baseline and at the one-month and three-month follow-ups using a pre-and post-test semi-structured questionnaire. Descriptive data are presented using measures of central tendency and their respective measures of dispersion. No comparative statistical analysis was performed.

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In doped calcium fluoride transparent conducting powder were prepared by solid-state reaction method. Structural properties of the samples were investigated as a function of various In-doping levels (x=0.00-0.01-0.02-0.03). The results of x-ray diffraction have shown that the samples are polycrystalline structure in cubic phase and show presence (111), (220), (311), (400) planes in pure CaF2 sample and the preferred orientation is (220) for pure CaF2 and we have peaks correspond (101), (112), (200), (202) for In for all samples and the preferred orientation is (112) for In for all samples. The average of crystallite size is within the range [2.976-0.845nm] for all samples. The relative intensities, distance between crystalline planes (d), crystallite size (D) and lattice parameters (a) were determined. Measuring the infrared spectrum of pure Calcium fluoride, it is found that there are six vibratory frequencies, namely: (3444.52 - 1517.59 - 1138.40 - 876.40 - 639.93 - 436.29) cm- 1 and six vibratory frequencies for indium doped calcium fluoride at 3wt%. (3441.94 - 1516.77 - 1138.44 - 876.55 - 642.09 -436.44) cm- 1 The study showed that the absorbance values, the absorption coefficient, the refractive index and the optical length were in the indium doped sample by 3wt% greater than that of the pure Calcium fluoride compound and are respectively: α=14.163 cm-1 n=1.767.

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Before the development of highly active antiretroviral medication, AIDS and related illnesses caused a great deal of suffering and death. All of the AIDS-related morbidities and mortality have considerably decreased thanks to modern medication, especially in industrialized nations. However, this accomplishment is still elusive in underdeveloped nations, particularly in those in sub-Saharan Africa. This failure can be attributed to a number of factors. Poverty, ignorance about the treatment, and inadequate therapy adherence are at the top of this list.

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Using kinetic differential equations and the Runge-Kutt algorithm, an analysis of the pathological processes occurring in the course of Alzherimer’s disease was carried out. Thanks to the appropriately selected kinetic equations, the presented model allows to explain the time course of the growth of pathological proteins: beta-amyloid and tau protein and the related loss of nerve cells. The model is based on previous experimental knowledge of Alzherimer’s diseas and is in good agreement with the experimental data.

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Objective: The purpose of this study was to compare the bioavalability between the two 80 mg Valsartan Tablets formulations and to evaluate the bioequivalence of Reference and Test formulations of Valsartan Tablets 80 mg in Healthy adult chinese Male and Female subjects under Fasting and Fed condition.

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Background: Manifold emulsions are used to increase the bioavailability of active medicinal ingredients and to provide a longer drug delivery mechanism. Hydrophobic and hydrophilic combinational surfactants are frequently used to stabilize the manifold emulsions.

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Background and Purpose: Ischemic stroke is a treatable medical emergency. The diagnosis of stroke is mainly clinical and not always so obvious. Intravenous thrombolysis treatment with altepase IV and endovascular treatment have been proved as fist-line beneficial options for eligible patients who have acute ischemic stroke. However, approximately 30% of patients who experience an acute neurological deficit compatible with ischemic stroke fall into the category of "stroke mimics"

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Intracranial hemorrhage (ICH) is a life-threatening complication in hemophilia. It often occurs during childhood after minimal head trauma. It poses a problem of diagnostic and therapeutic management, especially in Africa where CFCs are not always available.

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The study investigated the effects of climate change and adaptation strategies among Orange Fleshed Sweet potato (OFSP) farmers in Anambra East and West local government in Anambra State, Nigeria. The specific objectives of the study were to assess the sources of information on climate change by the farmers, determine the causes of climate change in the study area, ascertain the perceived effects of climate change on OFSP farmers, assess the adaptation strategies used by the farmers and identify constraints to climate change adaptation strategies.

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Dental practice involves a risk of exposure to microorganisms causing many infectious diseases. The risk of contamination starts at the beginning of the prosthetic workflow through impressions. Various chemical disinfection protocols for dental impressions are reported in the literature.

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The study assessed factors affecting fertilizer applications by yam farmers in Edo State, Nigeria. The specific objectives were to: ascertain the basic source of information among the farmers, determine the factors affecting fertilizer applications on yam production and the constraints working against yam production in the study area. Multistage sampling techniques were used in this study.

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The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.

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Carbon nanotube (NT) based electronic vapor sensors were tested against synthetic sweat solutions, consisting of 13 volatile organic compounds (VOCs) in saline, in order to probe the device ability to analyze and differentiate vapors derived from complex biological samples.

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The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.

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Anodic aluminum oxide doped with vanadyl citrate chelate complex anions was formed by a two-step self-organized anodization in 2 wt. % sulfuric acid containing 0.04 M V2O5 and 0.08 M citric acid at voltage range 13-23 V, and at 0 and 15 oC. The combination of two temperatures and at least four voltages (depending on the applied temperature) was applied as the operating conditions of anodization.

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