Articles Related to lipid

Objectives: Recent studies have shown that exercise by affecting bones causes the release of hormones that are effective in regulating blood glucose, lipid profile and preventing vascular calcification. The present study aims to Comparison effect of aerobic and resistance exercises on Osteocalcin and Metabolic Profils in Overweight men. Methods: total of 33 overweight healthy men (BMI 29 = 67.96 ± 0.96 and age 33.2 ± 2.23) were randomly assigned into three groups: control (n = 11), aerobic (n = 11) and resistance exercise (n = 11) groups. The training program was conducted for 8 weeks, 3 sessions per week for the training groups. Body compositions parameters (weight, body fat percent, BMI) were analyzed, osteocalcin and blood biochemical parameters were assessed from fasting blood samples before and after 8-week exercise programme. Results: Body fat, BMI and body weight reduction following exercise (P<0/05), significantly increased serum Osteocalcin (P<0/05, baseline vs Post exercise) and blood biochemical parameters significantly changes (P < 0/05). Increase in osteocalcin had a negative correlation with changes in body composition, as well as HOMA-IR and HDL, LDL not significantly (all P > 0/05). Conclusion: Aerobic and Resistance exercise cause to changes in body weight, body fat, BMI, as well as the increase level of osteocalcin and improvement of glucose metabolism and lipid profiles. However, the difference between the two training groups was not statistically significant.

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Low temperature (but above-freezing) during germination and early seedling growth of chilling-sensitive crop is one of the most significant limiting factors in the productivity. 2,4-Epibrassinolide (24-EB) is one of the most active forms of brassinosteroids are multifunctional plant hormones that can regulate development and respond to abiotic stresses. The effect of seed-pretreatment with 24-EB (12.5 μg/L) on photosynthetic characteristics, membrane permeability, lipid peroxidation and antioxidant activities under chilling stress were investigated in tomato (Lycopersicon esculentum Mill.) cultivars: Kulon (early ripening) and Yakhont (mid-early). Results showed that the use of 24-EB led to more pronounced changes in the pigment composition in Yakhont in the absence of a stress factor, whereas in Kulon under chilling stress (2 o C for 24 h). 24-EB pretreatment minimized the damage to cell membranes in tomato plants caused by chilling stress. The tolerance to chilling stress in Yakhont was higher than Kulon (by electrolyte leakage and content of malondialdehyde assay). Under these conditions, oxidative processes in plants of Yakhont did not show significant difference. We have not established the effect of 24-EB on the level of low molecular weight antioxidants in tomato cultivars (measured by inhibition of 2,2-diphenyl-1-picrylhydrazyl free radical method). The antioxidant activity of leaf extracts in Yakhont was twice as high as in Kulon under all experimental conditions (with/without 24-EB, 22/2 o C). It was concluded that the less pronounced reaction of plants of Yakhont to the use of 24-EB and chilling stress is due to their genetically determined higher cold resistance than that of Kulon.

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Background and Objective: In Cameroon, given the galloping growth in the prevalence of diabetes, in particular type 1 diabetes in the northern regions, we undertook this study, with the objective to improve the management of type 1 diabetes by determining the socio-demographic, clinical characteristics and lipid profiles of the patients followed in the care centers of regional hospitals of Maroua, Garoua and Ngaoundere. Methods: We undertook a descriptive cross-sectional study from 07 August 2018 to 07 May 2019 in the care centers of the regional hospitals. Sociodemographic and clinical data were collected by interview to consent patient through structured questionnaires in the survey sheet. Anthropometric data were also determined during the survey, and the blood was collected in referred laboratory for determination of some lipid profiles parameters. Results: On a sample of 467 Patient suffering from diabetes, 68 were of type 1, representing a prevalence of 26%. Type 1 diabetes Patients were mostly female (61.8%) and the mean age was 20.72 ± 3.4 years with a high percentage between 20-30 years (51.5%). More than half of our patients were pupils and students, many of them practiced Muslims as religion (58.8%). In most of cases (51.3%), the disease was diagnosed after one year as a result of illness. The majority of our patients were non-smokers (98.5%) and less athletic (32.4%). The mean Body Mass Index (BMI) was 23.03 ± 2.7 kg /m2 with an average waist circumference of 80.26 ± 9.23 cm in men and 82.15 ± 10.45 in women. Their treatment was based essentially on insulin therapy, mainly using regular and intermediate insulins. More than half of the subjects had high blood glucose (78.1%), high triglyceride (34.1%) and HDL-cholesterol (29.3%) levels. Most of the patients suffered from overweight/obesity, high blood pressure, arthritis, kidney failure and other diseases (malaria, jaundice, stomach ache). No significant relation was found between clinical and the sociodemographic and blood lipid profiles. Conclusion: It emerges from this study that type 1 diabetes represent high proportions of diabetes cases in septentrional area of Cameroon, and affect mostly young of less than 30 years old, dominated by women, practicing Muslim as religion. Their clinical profile characterized by high frequency of overweight/obesity, kidney failure and arthritis vary, but not significantly, with neither their sociodemographic nor their blood lipid profiles. Absence of sport, female and less control of their hypoglycemia are factors risks of the progression of the disease.

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The ability to measure structural and functional alterations in cellular and tissue lipids with small footprint, accessible instrumentation has sparked interest in their role in disease pathology. However, various lipidomic analytical tools tend to be cumbersome and time-consuming. A rapid, accurate, and straight forward peak alignment software routine would greatly facilitate the analysis of large datasets, such as those produced by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Herein, we describe a novel Rapid Peak Alignment Method (RPAM) which allows untargeted analysis of lipids expressed in brain white matter following chronic ethanol exposure in an established experimental model. The RPAM outputs data comparable to manual peak alignments but the processing time requires only 90 minutes instead of 8-10 hours. This method is readily adapted to a broad range of models, tissue types, and human diseases.

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Obesity greatly increases the risk of metabolic diseases and preventive approaches for obesity are often insufficient to effectively prevent the diseases. Altering feeding time strategy intervention decreases caloric intake without calorie counting and may be an effective therapy. Therefore, this study investigates the effect of 4-h time restricted feeding on body weight, leptin concentration and lipid profile in healthy non-obese male Wistar rats.

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The fruit of Crataegus dahurica Koehne ex C.K. Schneid is an edible wild fruit and herb for the treatment of various diseases. However, few studies were conducted to search the chemical constituents of the edible herb. In the present study, a new glycoglycerolipid (1), together with ten known compounds, 2-oxo pomolic acid (2), cecropiacic acid (3), nikoenoside (4), garcimangosone D (5), ampelopsisionoside (6), saussureosides B (7), 6-O-[(2E, 6S)-2, 6-dimethyl-6-hydroxy-2, 7-octadienoyl]-α-D-glucopyranoside (8), 6-O-[(2E, 6S)-2, 6-dimethyl6-hydroxy-2, 7-octadienoyl]-β-D-glucopyranoside (9), betulalbuside A (10), quercetin (11), were isolated from the fruits of C. dahurica with various chromatographic techniques.

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microRNAs play critical roles in cancer metabolisms. miRNA-181a-5p is significantly down-regulated in non-small lung cancer tissue and mesenchymal like lung cancer cells. Epithelial-mesenchymal transition mechanisms and cancer metabolism are controlled by the same signaling pathway.

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Part of the study was to assess the concentration of secondary metabolic (total: phenolic, flavonoid, and proanthocyanidin, tannin) and the antioxidant activities in methanol (MeOH) and methanol-water (MeOH-H2O) extract of GnA.

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The experiment was conducted to investigate the effect of induced hyperlipidemia in SD rats fed with high fat diet (HFD) for 7 weeks on blood lipid profile and possible pathological changes in liver, stomach, intestine, heart, spleen, lung and kidney. There were significant differences in most rats which induced hyperlipidemia throughout the experimental period with the blood lipid levels and histopathology.

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To determine the proportion of human milk (pooled and homogenized) fat loss via feeding tube in a simulated 24-hour feeding cycle. Anonymous samples of frozen human milk were obtained, thawed and pooled (pHM) in a 1000 mL glass beaker with a magnetic stir bar. Eight syringes (30 mL each) were prepared and attached to 60” extension tubing and a 5 FR polyurethane or silicone nasogastric (NG) tube. Samples to test for pool uniformity were collected at the beginning, middle and end of syringe preparation. Milk was delivered sequentially via gravity, 30-minute or 60-minute infusion. Pooled human milk was analyzed for macronutrient content at the end of each feeding “cycle”. All scenarios were repeated using homogenized donor human milk (hDHM).

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The coexistence of chronic diseases has led to greater negativity in patients than the negativity of diseases individually speaking. The aim of this study was to investigate the effects of the body mass index on metabolic profile, isometric and isokinetic muscle strength, static and dynamic balance, and anaerobic capacity in dyslipidemia patients, as well as to emphasize what exercises should be recommended for recovering the experienced functional loss of the patients. Forty five patients (26 women, 19 men) between 40 and 75 years of age and who were newly diagnosed as dyslipidemia were enrolled into this study. The patients were divided into two groups according to their body mass indexes (BMI): group 1 (n:18) or those whose BMI was lower than 25 kg/m2, and group 2 (n:27) or those whose BMI was higher than 30 kg/m2. Biochemical blood sampling was done. The Get Up and Go, single leg stance, anaerobic capacity, and isometric as well as isokinetic muscle strength tests were performed in order to evaluate functional capacities. There were no statistically significant differences shown at gender distribution, age, or height (p>0.05) between groups. The weight and BMI’s between the groups were statistically significantly different (p<0.05). The fasting glucose levels and triglyceride levels of group 2 was statistically significantly higher than group 1 (p<0.05), whereas other biochemical parameters showed no differences (p>0.05). The static balance tests results between groups have shown no statistically significant differences (p<0.05); however the dynamic balance test results for group 2 was statistically significantly worse than those of group 1 (p<0.05). The parameters of the results of the anaerobic testing, alongside those of the isometric and isokinetic testing for group 1 patients were statistically significantly higher than those of group 2 (p<0.05). Obesity negatively affects dyslipidemic patients’ metabolic and functional capacities. An exercise program for dyslipidemic patients with a high BMI should include strengthening and balance as well as dynamic balance exercises in order to positively influence both their metabolic profiles and functional status.

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All organisms age, in the search of the universal mechanisms of aging Barja analyzed results obtained with various species of mammals and birds and concluded that only two known factors correlate in the right sense (inversely) with animal longevity in vertebrates: the long life span is associated with (a) low rates of mitochondrial reactive oxygen species production, and (b) low degree of fatty acid polyunsaturation of cellular membranes including the mitochondrial ones [Barja (2014) Prog Mol Biol Transl Sci. 127:1-27].

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Investigate the use of cardiac resynchronization therapy (CRT) in cancer patients with heart failure (HF); assess factors associated with ischemic and non-ischemic HF. Many newer cancer therapies are cardiotoxic; thus, the incidence of HF has been increasing in this high-risk patient population. CRT has beneficial effects on morbidity, mortality, and left ventricular function in patients with non-ischemic cardiomyopathy, yet cancer patients and survivors who develop severe HF and are eligible for CRT often does not receive it.

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PLIN2 belongs to one member of PAT (Perilipin, Adipophilin and Tip47) family, which plays an important role in regulating lipid storage and could be regarded as a candidate gene for intramuscular fat deposition in pigs. This study tried to clone the coding domain sequence (CDS) of PLIN2 gene, compare the nucleotide acids and deduced amino acids sequence, physiological characteristics, structure and the expression level between Wujin (fatty breed) and Landrace (lean breed) pigs. The results showed that the mutation of nucleotide acids led to the mutation of deduced amino acids between two pig breeds.

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The rise of chronic non-communicable diseases (CNCD), mainly cardiovascular disease, obesity and cancer, has been assumed to be a consequence of the increase intake of fatty foods, especially saturated fats and cholesterol.

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