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Articles Related to neoplastic

Assessment of Antioxidant and Antineoplastic Activities Blumea Lacera (Burn. F) Leaves

Blumea lacera (Burn. f.) DC. (Family: Asteraceae) is an important member of Bangladeshi natural plant resource and it is an herbaceous weed locally known as Kukursunga. Different parts of this plant are used traditionally to cure various diseases. But detail study on the antioxidant and antineoplastic potentials of Blumea lacera leaves, has not yet been done. Aim of this study is to examine the antioxidant and antineoplastic properties and quantify the different type of phytochemical content of the methanolic extract of leaves of Blumea lacera (MELB). MELB contained a rich polyphenol, flavonol, flavonoid and proanthocyanidins. MELB showed moderate cytotoxic effect against Artemia salina (brine shrimp nauplii) where its LD50 values was 66.12 μg/ml. In vitro antioxidant assay, MELB exhibited a remarkable capacity to scavenge the tested reactive species. MELB scavenged DPPH with an IC50 of 33.64 μg/mL and 42.69 μg/mL, respectively. In vivo antineoplastic assay, MELB significantly (P<0.05) decreased viable cell count and increased the survival time of EAC cell bearing mice. Hematological profiles were also restored significantly (P<0.05) to normal levels in MELB treated mice as compared to untreated EAC control mice. In addition, fluorescence microscopic view of EAC cells derived from MELB-treated group showed apoptotic characteristics in treated cells compared to untreated EAC control. our findings suggest that methanolic extract of Blumea lacera leaves(MELB) might be a potential agent with antioxidant properties for prevention of cancer and has the merit for further investigation in isolating its active constituents.
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Paraneoplastic Urticarial Vasculitis and Recurrence of Prostatic Adenocarcinoma

Chronic urticaria is a common condition but its etiology can sometimes be serious. A variety of causes has been reported to induce urticaria, like food, infections, drugs or environmental factors. Although an association between chronic urticarial and malignancy has been occasionally reported, such association remains controversial because it’s difficult to demonstrate it’s not just coincidental. However, various cancers have been described in connection with this skin pathology such as thyroid, pulmonary or renal carcinoma. In all of these cases, treatment of the tumor led to prompt resolution of the urticarial lesions, thus suggesting a pathogenetic relationship between the two. We report the case of a man treated for several months without success for chronic urticaria whose treatment of the recurrence of his prostate cancer has removed the skin lesions.
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The Emergence of Multiple Myeloma in a Patient with Essential Thrombocythemia: A Case Report

Multiple myeloma is a neoplastic disease characterized by neoplastic proliferation of plasma cells and monoclonal protein expression and related tissue damage.In the presence of overt clinical signs, the disease can easily be diagnosed, however in order to diagnose atypical cases, further investigation is needed with high clinical suspicion.
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Development of Severe Hypophosphatemia from Acquired Fanconi Syndrome during Treatment with Abiraterone

The first patient was a 77 year old man who had been on abiraterone for 12 months before his phosphorous was checked. At that point, it was 0.6 mg/dl, which is severely decreased. A full work up for hypophosphatemia showed normal parathyroid hormone and 25-hydroxyvitamin D. A urine study showed inappropriate excretion of phosphorous along with aminoaciduria and normoglycemic glucosuria.
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Perspectives and Potential Applications of Ruthenium-Based Nanocarriers for Cancer Therapy

Cancer is a highly heterogeneous disease characterised by continuous uncontrolled growth and expansion of abnormal cells. In general, in tumor cells the signalling pathways regulating cellular processes, as cell growth and division and cell to cellcommunication result strongly altered.
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Editorial Board Members Related to neoplastic

Julie Teruya-Feldstein

Director
Hematopathology
Immunohistochemistry Laboratory
United States

MASSIMO RUGGE

Professor
Department of Pathology
Padova University
Italy
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