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Articles Related to permeability

Investigation of the Characteristics and Performance of Compatibilized PLA/P CL Blends and Their Nanocomposites with Nanocalcium Carbonate

In this research, (Poly lactic acid)(PLA)/Poly(ε-caprolactone)(PCL) blends containing 2 and 3 phr glycidyl methacrylate (G MA) as a chain extender, and nanocomposites of compatibilized and uncompatibilized PLA/PCL containing 7 and 9 phr nanocalcium carbonate (NCC) were prepared via melt mixing. The crystallinity, tensile properties, morphology, permeabili ty and rheology of the samples were investigated. The results showed that using 25 wt. % of PCL leads to optimum proper ties of PLA/PCL blends. The crystallinity of this sample was increased from 5 (for neat PLA) to 27% in the sample contain ing both GMA and NCC. In addition, the elongation at break of the compatibilized blend is improved up to 180% in com parison to neat PLA. The result showed that the barrier properties of PLA/PCL blends were increased by the crystallinity en hancement of PLA and the intrinsic low permeability of PCL. It was found that the addition of 9 phr NCC to this sample promotes crystallinity and barrier properties, but causes lower tensile properties of blends. Finally, the use of NCC and GMA simultaneously results in lower crystallinity and barrier properties, which could be due to the phase separation of com ponents in the blends. The barrier properties of some samples like compatibilized nanocomposite in composition of 9 phr NCC are closer to PE and PP and thus suitable for replacing of oil based polymers
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Study of Microalbuminuria and its Correlation to Prognosis in Patients with Traumatic Brain Injury: A Longitudinal Study at Level 1 Trauma Centre

Microalbuminuria reflects rapid changes in glomerular permeability and is associated with systemic capillary permeability.
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Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites

Ovarian cancer constitutes the second most common gynecological cancer with a five-year survival rate of 40%. Among the various histotypes associated with hereditary ovarian cancer, high-grade serous epithelial ovarian carcinoma (HGSEOC) is the most predominant and women with inherited mutations in BRCA1 have a lifetime risk of 40-60%. HGSEOC is a challenge for clinical oncologists, due to late presentation of patient, diagnosis and high rate of relapse. Ovarian tumors have a wide range of clinical presentations including development of ascites as a result of deregulated endothelial function thereby causing increased vascular permeability of peritoneal vessels.
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Review on Transdermal Drug Delivery Systems

Recently, transdermal drug delivery system (TDDS) has become a more and more important approach to administering drugs. Based on its advantages, which are not achievable by other modes of administration, many researchers are dedicated to the study of it, and have made great progress. Although the skin offers a painless interface for systemic drug delivery, it also presents limitations which are mainly caused by the stratum corneum.
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Targeted Approach for Prostate Cancer Treatment: Synthesis and Characterization of Docetaxel-Loaded Perfluorocarbon Nanodroplets

The purpose of this study is to synthesize and characterize nanodroplets, loaded with docetaxel for treatment of prostate cancer under MR-guided focused ultrasound. Water insoluble docetaxel encapsulated in nanodroplets is expected to be delivered into tumors with greater efficiency while minimizing drug related systemic toxicities when used in combination with focused ultrasound. The sequence of our studies toward development and characterization of docetaxel-loaded nanodroplets is as follows. First, we developed methods for synthesis of ultrasound-responsive, docetaxel-loaded nanodroplets (Doc-nd) by a solid dispersion technique. Secondly, we characterized Doc-nd by its morphology and size distributions using a dynamic light scattering (DLS) method.
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Editorial Board Members Related to permeability

Ana Rita Ramalho Figueiras

Faculty of Pharmacy
University of Coimbra

Yan-Hua Chen

Associate Professor
Department of Anatomy and Cell Biology
Brody School of Medicine
East Carolina University
United States
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