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Costimulatory Molecules CD80 and CD86 Colocalized in Neutrophil Extracellular Traps (NETs)

Neutrophil extracellular traps (NETs) have been proposed as vehicles for the sensitization of T cells by decreasing their activation threshold.
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IL-8 Regulates Epithelial-Mesenchymal Transition through pERK1/2 in AGS Cells

The aim of this project was to evaluate the influence of inflammatory cytokines IL-1β and IL-8 on gastric epithelial-mesenchymal transition in gastric epithelial cells.
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Human Neutrophils in Patients with Positive Serology for Chagas Disease

Polymorphonuclear (PMN) neutrophil leukocytes are cells of innate immunity recognized in a peripheral blood smear because of their particular multilobed nucleus. Ring shaped nucleous are typical in rats and mice, being described in some pathologies in humans as well as in healthy subjects.
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Increased High Mobility Group Protein A2/SMAD3 Relates to Ovarian Cancer Progression

The high mortality associated with ovarian cancer is generally related to the development of drug-resistant disease. HMGA2 protein, a member of the high-mobility group AT-hook (HMGA) family of non-histone chromatin binding factors, is overexpressed in high-grade serous ovarian and tubal carcinomas, though little is known about its contribution to disease progression and drug resistance. We sought to assess whether compositional changes in HMGA2 production were associated with ovarian cancer progression.
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Toxic Effect of Titanium (Tio2) on Wistar Rat (Rattus Norvegicus) Injected by Intravenously

Titanium dioxide (TiO2) (<100 nm) has been widely used in the production of paints, paper, and plastics, as well as in food additives and colorants .It has been classified as biologically inert in both humans and animals. Here we studied the toxicity of TiO2 on Wister rat. Main exposure area of NPs is caudal vein of Wistar rat.
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Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins

The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.
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