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Articles Related to plasma

Immunity to Anaplasma marginale and Recent Advances in Vaccine Development

Anaplasma marginale is the etiological agent of bovine anaplasmosis, one of the most prevalent tick-borne diseases of cattle in tropical and subtropical regions that causes significant economic losses to cattle industry. Cattle that survive infection remain persistently infected for life. Immunity against A. marginale infection seems to require both humoral and cellular mechanisms. Antibodies against A. marginale neutralize bacteria by interacting with Major Surface Proteins (MSPs). For this reason, MSPs are believed to be one of the best candidate antigens for vaccine development. Research carried out in the last few years has helped us to understand the antigenic composition of A. marginale and to develop new potential vaccine formulations. Desirable bovine anaplasmosis vaccine must induce protective immunity as well as prevent infection and transmission
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Advanced Oxidation Plasma Air Purification to Mitigate Hospital and Restroom Odor Issues

Background: The smell in a hospital is an amalgam of smells, emanating from varied sources. But primarily the smell is from the strong cleaning agents used in corridors, including phenyl and bleaching powder, etc. Chemicals that trigger odors may cause health effects. A strong urine odor is also responsible for foul smells in hospitals and other public facilities. Strong odors may cause some people to feel a burning sensation, leading to coughing, wheezing, or other breathing problems.
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Reversed-Phase High Performance Liquid Chromatography Procedure for the Determination of Isavuconazole in Human Plasma

Introduction: Isavuconazole is an antifungal drug used for treating patients with invasive fungal infections. Efficacy and safety of isavuconazole is monitored by measuring plasma isavuconazole concentration using LCMS which is a non-affordable method. We used the HPLC system with a UV detector to measure plasma Isavuconazole concentration. Objective: Improved Reversed-phase high performance liquid chromatography procedure with UV detection is described which is cost effective, simple, precise and easily processed for the measurement of Isavuconazole, a drug used to treat the patients with invasive fungal infections, in blood plasma. Method: The method involves protein precipitation, addition of ammonium dihydrogen phosphate and chromatographic separation on a Hypurity C18 Column using an isocratic mobile phase of acetonitrile and ammonium acetate buffer (pH 8.0, 10 mM) (55:45, v/v). The UV detection was performed at 285 nm. The method provides rapid resolution of Isavuconazole in a 50 uL injection. Result: Lower limit of Quantification (LLOQ) is 0.25 μg/ml in a 50 uL injection volume for Isavuconazole with a recovery consistently > 100 %. The assay is validated over linear range of 0.25 to 10 μg/ml. The intra-assay precision is < 3.53 % and inter-assay is <6.38% relative standard deviation of Isavuconazole. The method demonstrated clean separation, clinically acceptable detection limit and a linear range upto 25 ug/mL. Conclusion: The assay demonstrated applicability in quantifying the drug level and monitoring the therapeutic dose for maintaining effective biological level to have better response in fungal infected patients. The method is cheaper as compared to LC-MS/MS and Tandem Mass spectrometry and the results are reportable on the same day of blood collection.
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An Unexpected Diagnosis of Plasmacytoma of The Thyroid: A Case Report and Review of The Literature

Plasmacytoma is a malignant proliferation of plasma cells that can arise in the bone marrow (osseous) and in the soft tissues. Extramedullary plasmacytomas most commonly occur in the upper respiratory tract. Thyroid involvement is rare. In this report, we describe a new case plasmacytoma of the thyroid gland in a 60-year-old man with a history of multinodular goiter present for several years and an unexpected rapid increase of the mass associated to dysphagia, dyspnea, and dysphonia. Histopathological examination of surgical specimen, along with immunohistochemical studies, unexpectedly led to the diagnosis of plasmacytoma. We also briefly summarize the last 30 years of literature on thyroid plasmacytoma and review the salient characteristics of this rare condition.
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Optical Depth Measurement of Self-Reversed Line Emitted from In-Homogenous Plasma in Laser Induced Breakdown Spectroscopy

In this work, an original method is proposed and used for measurement of the optical depth of a self-reversed spectral line. A theoretical approach is utilized in an in homogenous laser induced plasma at local thermodynamic to simulate self-reversed line and then to get the main line profile without self-absorption. In this research, the spatial and temporal evolution of optical depth of two spectral lines of Ca II at 393.4 nm and 396,9 nm is studied. Furthermore, the variation of optical depth versus the concentration of species emitter inside of plasma plume is investigated. In addition, the validity of this method is affirmed during comparison with results obtained by other techniques.
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Plasma Exchange for Neuroborreliosis Associated with Guillain Barre Syndrome

Lyme neuroborreliosis (LNB) is a rare infectious disorder of the nervous system caused by Borrelia burgdorferi spirochetes. Different neurological conditions were reported in the disease.
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Blastic Plasmacytoid Dendritic Cell Neoplasm Presenting as a Harbinger of Acute Myeloid Leukemia

A 51 year old female was referred to our dermatology clinic for a rapidly growing lump on head of 6 weeks duration. On examination we observed a 15 cm diameter erythematous crusted tumor on the forehead with significant bilateral cervical lymphadenopathy. An excision biopsy of the tumor revealed a malignant high grade diffuse undifferentiated infiltrating neoplasm involving the skin and subcutaneous tissue.
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Amiodarone Prevents Atrial Fibrillation Induced by Arsenic Trioxide in Extramedullary Plasmacytoma Involving Lumbar Disc: A Novel Case Report

Extramedullary plasmacytoma (EMP), characterized by infiltration of malignant plasmablastic clones outside the bone marrow in absence of multiple myeloma.
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Clinicopathological and Prognostic Value of Plasmacytoid subtype in Bladder Cancer: A Systematic Review and Meta-Analysis

The World Health Organization, in 2004, published a new classification that recognizes different histological variants (HV) of urothelial carcinomas
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Determination of N-Butylscopolamine in Human Plasma by Solid-Phase Extraction and UHPLC-ESI-MS/MS: Development, Validation and Application to a Bioequivalence Study

BioequivalenceA sensitive ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) method for measurements of N-butylscopolamine in plasma was developed and validated. A SPE extraction was proposed for the clean up of plasma and N-butylscopolamine-d9 was added as internal standard. The analyses were carried out using a phenyl column and mobile phase of acetonitrile:
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Cattle Ticks and Tick Borne Haemoparasite Species Identification and Associated Risk Factors in Two Districts of West Arsi Zone, Ethiopia

Different tick species and tick-borne diseases of cattle are present in Ethiopia and they induce huge production loss in livestock industry by creating serious animal health problems. The present study was conducted from November 2017 to April 2018 in Arsi Negele and Asasa districts of West Arsi Zone, Oromia National Regional State, Ethiopia. A cross sectional study design and purposive sampling technique were employed to select 384 study animals so as to identify ticks species and tick-haemoparasite species and also to identify risk factors that affect the prevalence and association of tick born diseases. Tick and haemoparasite identification were carried out by using drect stereomicroscopic and direct thin blood examination. The study identified two tick genera and four tick species. The tick species encountered were Rhipicephalus decoloratus (51.6%) Ambylomma variegatum (46.1%) Ambylomma gemma (20.1%) and Rhipicephalus evertsi evertsi (1.2%). Out of all 384 cattle examined for the presence of tick-born haemoparasites 11.4% (n=44) of them were positive. From this 6.2%, 3.6 %, 1.3% and 0.8% of them were positive for Anaplasma marginale, Babesia bigemina, Babesia bovis and Anaplasma marginale, respectively. Two cattle (0.5%) were found positive for both Anaplasma marginale and Babesia bigemina. The highest prevalence of total tick born haemoparasites (57.1%) was occurred in A. Variegatum, A. gemma and R. decoloratus mixed infestations. In conclusion ticks and tick born haemoparasitic infections were common problems in the study area. Thus, awareness creation for farmers about the impacts of ticks and tick born diseases on livestock production and productivity and also applying appropriate and timely strategic tick control methods by veterinary service providers were advisable.
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Solitary Plasmacytoma of the Thoracic Spine

Solitary bone plasmacytomas account for approximately 5% of plasma cell malignancies. These lesions are recognized as pre-malignant, if untreated, at least 50% will progress to multiple myeloma within 5 years of diagnosis. We present a case of a 54 year old male patient whom presented to our unit complaining of progressive axial backache complicated by acute onset paraplegia of 8 hours duration. Neurological examination revealed an incomplete L1 sensory level and no motor function of his lower limbs which had power 0/5 in all dermatomes (Frankel B).
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Quality of Life after Accidental Major Vascular Injury and Prolonged ICU Stay - A Case Report

Survival or mortality rate is a reasonable choice of an outcome measure for critically ill patients in intensive care unit (ICU). But it is also important to assess the impact of critical illness and peri-operative complications on health status and quality of life (QoL) after hospital discharge. The QLQ-C30 is a 30-item cancer-specific questionnaire that incorporates five functioning scales (physical, role, cognitive, emotional, and social), eight symptoms scales, perceived financial impact of the disease and a global scale [1-5].
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Novel Alternative Treatment to Plasmapheresis in Evans Syndrome

Evans syndrome is a rare haematological disease characterised by concurrent occurrence of autoimmune haemolytic anaemia (AIHA) and idiopathic thrombocytopenic purpura. The autoimmune haemolysis can lead to hyperbilirubinaemia, profound anaemia and haemodynamic instability. It can be difficult to treat and when refractory to medical treatment it could necessitate emergency splenectomy. Plasmapheresis is used in refractory haemolytic anaemia to aid removal of disease causing autoimmune complexes whilst immunomodulators act to reduce autoantibody response and effectiveness. However, this is an expensive and resource intensive process that is limited to tertiary referral centres. In this case study we present a successful novel alternative for life threatening AIHA in Evans Syndrome using haemofiltration with on-going fresh frozen plasma transfusion when resources are limited or it is not an accessible method.
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Multidimensional LC/MS-MS Analysis of Synthetic Cannabinoids in Urine, Plasma, and Edibles

Synthetic cannabinoids (SCs) present a multitude of problems in terms of maintaining up-to-date methods of detection. They are novel psychoactive substances originally synthesized for medical use and research purposes. Abuse has demonstrated a variety of effects ranging from euphoria to aggressive behavior and death. The marketing, similar naming, and described pharmacological interactions create the dangerous and false perception that SCs are similar to, or the same as, tetrahydrocannabinol in cannabis products
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Editorial Board Members Related to plasma

RAVINDRA K. MALIK

Professor
Natural and Forensic Sciences Department
Albany State University
United States

Joseph Prandota

Emeritus Full Professor
Department of Pediatrics & Clinical Pharmacology
Faculty of Health Sciences
Wroclaw Medical University
Wroclaw
Poland

Suresh G. Joshi

Associate Professor
Department of Microbiology and Immunology
Drexel University
United States

GAETANO GIAMMONA

Professor
Pharmaceutical Technologies
University of Palermo
Italy

Ock K. Chun

Assistant Professor
Department of Nutritional Sciences
University of Connecticut
United States

Julie Teruya-Feldstein

Director
Hematopathology
Immunohistochemistry Laboratory
United States

Baolin Zhang

Division of Therapeutic Proteins
Office of Biotechnology Products
FDA/Center for Drug Evaluation and Research
United States
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