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Complex Decongestive Therapy and Additional Physiotherapy in Male Breast Cancer: A Case-Report

Introduction: Male Breast Cancer is a very rare disease associated with delayed diagnosis and a more invasive or aggressive tumor therapy, i.e., surgery, radiation, chemotherapy and hormone therapy. Lymphedema, shoulder joint restrictions, posture failures, sensitivity disorders, pain or cancer-related fatigue are common complaints.
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Accidental Ammonia Gas Leakage in a Cold Storage : A Case Report

: Ammonia is corrosive and exposure will result in a chemical-type burn. It is highly hygroscopic and readily transforms the moist areas of the body such as eyes, nose, throat, and moist skin areas. It is a highly toxic irritant gas, and its toxicity usually occurs from occupational exposure, most are unintentional toxicity. It causes tissue damage via exothermic reaction with body tissues causing liquefactive necrosis. Release of ammonia has potentially for harmful effects on workers and the public. Although there have been incidents of exposure to harmful concentrations of ammonia in the world there have been few fatal accidents.Presentation depends on the level and duration of exposure. Management is supportive and its antidote is not available yet
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Radiographic Outcomes of FDBA Block Graft for Maxillary Ridge Augmentation: A Case Report

The primary donor sites for collecting bone in the oral cavity to replace missing ridges are the mandibular symphysis or ramus. Although successful, these bone transplants can nevertheless raise a number of issues, including donor site morbidity, nerve paresthesia, the devitalization of native teeth, and postoperative sequelae . Allogeneic block grafts were developed to address these concerns and a lack of autogenous intraoral bone available for grafting
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Case Report: Pyoderma Gangrenosum in IBD Treated with Tofacitinib

Pyoderma gangrenosum is a rare ulcerating skin disease often presenting as an extra intestinal manifestation of IBD and is difficult to manage. Treatment options for pyoderma gangrenosum include steroids, calcineurin inhibitors and anti TNF agents. Here in, we report a case of recurrent Pyoderma gangrenosum with Ulcerative Colitis that was successfully managed with Tofacintib, a JAK inhibitor
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Leukocytoclastic Vasculitis after Ceftriaxone Exposure: A Case Report and Literature Revie

Leukocytoclastic Vasculitis (LCV) characterizes various small vessel vasculitis types primarily affecting the skin, with occasional internal organ involvement. This inflammation involves immune-complex deposition within dermal capillaries and venues. Although idiopathic in origin, potential triggers, including antibiotic-related factors, must be considered. LCV presents across a spectrum of severity, sometimes extending to ulcers. Diagnosis involves clinical assessment, history, lab tests, and crucially, skin biopsy.
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A Case Report of Rapidly Progressing Amyotrophic Lateral Sclerosis in 31 Year Old Patient with Sympathovagal Imbalance

ALS is a fatal neurodegenerative condition characterized by degeneration of upper and lower motor neuron in cerebral cortex, cranial nerve nuclei and anterior horn cells of spinal cord. Three drugs are FDA approved, Riluzole, Edaravone and AMX0035 (recently approved), which can only prolong survival time by 2-3 months.
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Superficial CD34-Positive Fibroblastic Tumor: First Case Report from Latin-America and Review of the Literature

Superficial CD34-positive fibroblastic tumor is an infrequent soft-tissue tumor characterized by a lesion located in the subcutaneous fascia without affecting the soft or deep muscle planes. Its incidence is unknown; therefore, it represents a diagnostic challenge for both the surgical oncologist and pathologist. Given its high risk of local recurrence, extensive surgical resection is the recommended treatment modality. This is the first report of this rare entity in Latin-America.
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Right Atrial Myxoma with Critical Triple Vessel Disease: A Case Report

Cardiac myxoma are the most common primary heart tumor. It accounts for 40-50% of primary cardiac tumor. Approximately 75% occurs in left atrium and 15-20% in right atrium. Myxoma are usually polypoid, pedunculated lesion with smooth surface covered with thrombus. Most common site of attachment is at the border of fossa ovalis in left atrium but it can occur in any part of atrial wall. Symptoms are produced because of mechanical obstruction with cardiac blood flow, tumor embolization and constitutional symptoms due to increased expressions of IL-6. Echocardiography is the best diagnostic modality to localise the tumor. Surgical excision is the mainstay of treatment of myxoma present in any location.
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A Case Report of ST-Segment Elevation Myocardial Infarction With Non-Obstructive Coronary Artery Disease: an Economical and Beneficial Investigative Algorithm

Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a puzzling clinical entity, coupled with potential multiple pathophysiological mechanisms, often makes disease classification, investigation and management difficult. Despite presence of myocardial damage and increased risk for the future, many patients are discharged undiagnosed, thus the specific cause is not effectively treated.
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Multiple intracerebral hemorrhagic lesions complicating minimal cranioencephalic trauma in a child with severe hemophilia A, trisomy 21 and sickle cell trait carrier: a case report

Intracranial hemorrhage (ICH) is a life-threatening complication in hemophilia. It often occurs during childhood after minimal head trauma. It poses a problem of diagnostic and therapeutic management, especially in Africa where CFCs are not always available.
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Bilateral Palatal Necrotizing Sialometaplasia in Patient with Prurigo Nodularis: A Case Report

Necrotizing Sialometaplasia (NSM) is a rare, benign, self-limiting, inflammatory disease of mostly minor salivary gland origin. NSM can resemble a malignant lesion in its early disease course, both clinically and pathologically. Bilateral involvement of the hard and soft palate by the lesion is a rare occurrence. NSM was first described as a reactive inflammatory process. Since then, over 200 cases have been reported and has been added to the WHO classification of salivary gland tumours under the tumour-like lesions. Here, we report a case of a 30-year-old male with bilateral NSM of both the hard and soft palate, on a background history of prurigo nodularis. The patient was initially referred to an Oral and Maxillofacial Department by his general practitioner for a palatal ulcer, concerning for oral malignancy. The ulcer was painless with a well-demarcated border and necrotic base. Subsequent biopsy and histological examination confirmed necrotizing sialometaplasia with healing occurring within 5 weeks.
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Trend of HIV/AIDS Reported Cases in Morocco Between 1986 and 2019: A Time Series Analysis

Background: Morocco is a low endemic country of HIV/AIDS that achieved the goal of the second and third 90-90-90 targets in 2019 while still 78% of people living with HIV know their HIV status. The aim of this study was to analyze time trends of HIV/AIDS reported cases during the last 33 years taking into consideration the implementation of voluntary HIV counseling and testing (HCT) services in primary health care facilities. Methodology: This was a time series of HIV/AIDS reported cases at national level between 1986 and 2019. Variable collected for each year were HIV/AIDS reported per 100000 H, age category, gender, origin, CD4 count and route of transmission. Trend of HIV/AIDS reported cases was assessed by Joinpoint Regression Analysis. Annual percentage changes (APCs) were estimated to identify the years (joinpoint) when significant changes occurred in the trend. We therefore examined trends in HIV/AIDS reported cases according to epidemiological variables. Results: Cumulative HIV/AIDS reported cases during the study period was of 17 000. Joinpoint regression showed an increase in HIV/AIDS reported cases between 1986 and 2019. The APC for the period 1986-2012 was of 13.4 (95% CI: 12.0 to 14.8, p <0.05) and the APC from 2012 to 019 was of 5.4 (95% CI: 2.5 to 8.5, p<0.05) with a significant break in the same joinpoint year than HCT implementation in primary health care settings. In stratified analysis, HIV/AIDS reported cases increased but not significantly after joinpoint. A significant decrease was noted in 2015 in urban areas (APC = -10.0, 95% CI: -17.0 to -2.3, p<0.05). Conclusions: HIV/AIDS reported cases were increasing over 33 years, with a significant rise after 2012by 5% per year, corresponding to HCT integration into primary health care setting. Furthermore, Morocco is may be on the right way to eliminate HIV/AIDS in urban areas.
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Isolated Temporal Bone’s Paget Disease: A Case Report

Paget’s bone disease (PBD) is a benign tumor of osteoclasts. We report a case of an isolated temporal bone’s Paget disease with unusual evolution to a rapidly functional degradation of vestibulocochlear system. A 60 years old female was admitted for an isolated, left sided mastoid tumefaction without any inflammatory signs. Initial temporal bone computed tomography (CT) showed a left cotton wool appearance without any ossicles lesion or vestibulocochlear extension. Anatomo pathological tests confirmed the diagnosis. The outcome was marked by the occurrence of vestibulocochlear symptoms. Treatment had consisted on subtotal surgery in combination with oral bisphosphonate with improvement of her clinical conditions. The post operative’s follow-up was simple without any abnormalities. PBD of temporal bone is a benign disorder. Imaging is considered the most useful diagnosis modality for revealing the disorder that will be confirmed by histological tests. The treatment is based on medical approaches and surgery has few indications.
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Identification of Novel De-Novo 12q14 -12q22 Gene Mutations and MTHFR C677T Gene Polymorphism Increase Genetic Susceptibility in Hirschsprung Disease - A Rare Case Report

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Pseudotumor Cerebri Associated with Enteric Fever in a Child: A Case Report

Enteric fever is a common infection of tropical countries that can have a variety of neurological complications. Reported neurological complications are encephalopathy, eningism, spastic paralysis-cerebral origin, convulsions, meningitis, parkinsonian syndrome, sensory motor neuropathy, cerebellar involvement, and schizophrenic psychosis. The patient, who was diagnosed with enteric fever and started treatment, developed headache and blurred vision 5 days after the treatment. Cerebral venous sinus thrombosis secondary to enteric fever and related pseudotumor cerebri were detected in the patient. When additional symptoms develop despite treatment in patients with enteric fever, complications such as thrombosis and pseudotumor cerebri should be considered.
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Editorial Board Members Related to report

Claude Bakoume

Senior Research Officer
High Institute of Medical Technology
Cameroon

Alan Feest

Senior Research Fellow
Department of Faculty in Civil Engineering
University of Bristol
United Kingdom

Tingzhong Yang

Professor and Director of Social Medicine
Zhejiang University
China

Zeliha Selamoglu

Department of Medical Biology
Faculty of Medicine
Nigde Ömer Halisdemir University
Turkey

Marc G. Sturgill

Associate Professor and Chair
Department of Pharmacy Practice & Administration
Ernest Mario School of Pharmacy
Rutgers University
United States

NATASHA TASEVSKA

Assistant Professor
School of Nutrition and Health Promotion
Arizona State University
United States

HARRY E. RUDA

Professor
Department of Materials Science and Engineering
University of Toronto
Canada

Ashraf Naeem

Associate professor
Department of Anatomy & Embryology
Zagazig University
Egypt

Avinash Shankar

Chairman
National Institute of Health & Research
Warisaliganj (Nawada), Bihar
India

Maria Ioannou

Senior Lecturer
University of Huddersfield
United Kingdom
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