Articles Related to solubility
A Literature Review for Improving the Solubility of Poorly Water-Soluble Drug
Nanocrystal technology has showed significant potential for commercial applications and advancements as a novel pharmacological method to increasing the water solubility of certain poorly soluble medicines. Nanotechnology is the most effective
method for solving the solubility issues with medications in BCS classes II and IV. This article is primarily concerned with
the methods of preparing nanocrystals by means of Precipitation Lyophilization Homogenization (PLH) Technology. In particular, emphasised combinative technology could improve particle size reduction. Technology, equipment, and medication
physicochemical qualities affect particle size reduction success
Preparation and Performance Analysis of High Temperature Resistant and High Strength Alcohol Soluble Phosphate/Phenolic Hybrid Adhesive
A kind of alcohol-soluble phosphate adhesive was prepared by using phosphate solution as raw material. A hybrid high temperature and high strength adhesive was prepared by adding phenolic resin. The wetting condition of water-soluble and alcohol-soluble phosphate adhesive on the surface of hydrophobic material, the composition and mechanical properties of the adhesive were analyzed by means of liquid drop shape analyzer (DSA), X-ray diffraction instrument and universal tensile force machine. The results show that the
alcohol-soluble phosphate adhesive has good wetting effect on hydrophobic materials and has excellent high temperature resistance and mechanical properties.
Wet Granulation to Overcome Liquisolid Technique Issues of Poor Flowability and Compactibility: A Study to Enhance Glibenclamide Dissolution
The aim of this study is to apply wet granulation on liquisolid powders to overcome issues of poor powder flowability and compressibility especially with using high viscosity liquid vehicles. Different liquisolid formulations were made using three excipients where the effect of each excipient used in the dissolution of the model hydrophobic drug (Glibenclamide) was evaluated. The Glibenclamide tablets were formulated using PEG 400, Synperonic PE/L44 and Cremophor ELP, at a 10 %w/w in liquid vehicle drug concentration. The carrier (Avicel®PH102) was used followed by colloidal silicon dioxide (coating material) that converted the wet mixture into dry powder. Potato starch, 5%w/w, as a disintegrant was mixed with the mixture manually for 10 minutes and was finalized by adding 0.75% of magnesium stearate as a lubricant.
Case Series of Pneumococcal Meningitis in the Post 13-valent Pneumococcal Conjugate Vaccine Era
Streptococcus pneumoniae is a leading cause of meningitis. Although rates of bacterial meningitis have decreased after pneumococcal
conjugate vaccine introduction, pneumococcal meningitis has not been eliminated. In this case series, we describe the presentation,
serotypes, and outcomes of 11 children with pneumococcal meningitis at a tertiary children’s hospital after the 13-valent pneumococcal
conjugate vaccine (PCV13) was introduced, from 2011-2013. The median age of children with meningitis was 7 years. The majority
of the isolates (82%) were susceptible to penicillin. Most isolates (73%) were serotyped and there was no evidence of disease caused
by serotypes contained in PCV7
Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins
The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.
