Top Links

Articles Related to therapeutic

Iatrogenic Laryngotracheal Stenosis in Children: a Case Report

Laryngotracheal stenosis is one of the important causes of pediatric airway obstruction, and the etiology can be classified as congenital and acquired. With the widespread use of tracheal intubation and tracheotomy in pediatric emergency, iatrogenic laryngotracheal stenosis is gradually replacing trauma and infection as the major cause of acquired laryngotracheal stenosis [1]. Nowadays, open surgery is the first choice for severe laryngotracheal stenosis cases [1,2]. Here, we describe a case of childhood iatrogenic severe laryngotracheal stenosis, and the reflection on the current treatment methods of children with laryngotracheal stenosis.
View complete article: PDF  |  Full-text

Tofacitinib as a Therapeutic Option in the Treatment of Refractory Scleritis: A Case Report

This was a 50-year-old patient with recurrent bilateral nodular anterior scleritis refractory to several treatments, including immunosuppressants and anti Tnfα. She was assessed for the different causes of immune-mediated and infectious diseases, but nothing was found. Tofacitinib was started 5 mg twice a day, which led to the spacing of crises until their total disappearance. At present, the patient has been crisis-free for nine months. In conclusion, the use of Janus Kinase inhibitor (Tofacitinib) alone was effective in the treatment of refractory recurrent nodular anterior scleritis.
View complete article: PDF  |  Full-text

Ayurvedic Antiviral Agents: Overview of Medicinal Plants Perspective

In recent years it has been reported that many of the herbal plants contain antiviral agents which combat human disease that are caused by pathogenic viruses. The natural products which are obtained from plants as antiviral agents against viruses have gone through researches to check the efficacy and potentials of the herbal products in prevention of viral disorders.
View complete article: PDF  |  Full-text

Modified and Combined Lateral and Posterolateral Approach an Alternative Treatment to Tibial Plateau Fractures

The selection of a surgical approach for the treatment of tibia plateau fractures is an important decision. Approximately 7% of all tibia plateau fractures affect the posterolateral corner. Displaced posterolateral tibia plateau fractures require anatomic articular reduction and buttress plate fixation on the posterior aspect. These aims are difficult to reach through a lateral or anterolateral approach. The standard posterolateral approach with fibula osteotomy and release of the posterolateral corner is a traumatic procedure, which includes the risk of fragment denudation. Isolated posterior approaches do not allow sufficient visual control of fracture reduction, especially if the fracture is complex. Therefore, the aim of this case report was to present a surgical approach for posterolateral tibial plateau fractures that both protects the soft tissue and allows for good visual control of fracture reduction. The approach involves a lateral arthrotomy for visualizing the joint surface and a posterolateral approach for the fracture reduction and plate fixation, which are both achieved through one posterolateral skin incision. Using this approach, we achieved reduction of the articular surface and stable fixation in patients at the final follow-up visit. No complications and no loss of reduction were observed. Additionally, the new posterolateral approach permits direct visual exposure and facilitates the application of a buttress plate. This approach does not require fibular osteotomy, and fragments of the posterolateral corner do not have to be detached from the soft tissue network.
View complete article: PDF  |  Full-text

Caenorhabditis elegans (C. elegans) Used as a Whole Model Organism to Identify New Anti-Infectives Therapeutic Agent for MRSA Pathogens - A Review Paper

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the greatest fears with the number of serious infections on human health regarding antibiotic resistance. It causes a wide range of infections and bacteremia, ranging from inconsequential superficial skin infections, wound suppuration, even pneumonia or deep-seated tissue infections, which may lead to sepsis and fatalities.
View complete article: PDF  |  Full-text

Metaphysical Analysis of the Nutritional and Therapeutic Value of Baobab (Adansonia Digitata L.)

Realistic assessment of the yield and nutritional value of baobab as well as the elucidation of its inhibitory action against oxidative stress were the targets of the study. An average baobab tree can yield 80kg fruits, 14kg pulp, 23kg seeds and 130kg leaves per year. Despite considerable variability, the leaves outstrip in mean Ca (1241 mg/100g dry sample), Fe (40mg/100g dry sample) and ß-carotene (135μg/100g dry sample) content.
View complete article: PDF  |  Full-text

DNA Polymerase as Therapeutic Intervention for Treating Patients with Multiple Sclerosis

In recent years, increasing evidence has pointed to the potential role of fibrinolysis in the pathogenesis of MS. Based on hypotheses describing the aggressive autoimmune responses observed in MS patients, a result of impaired between (t-PA and PA1-1) which are a key molecules in both fibrinolysis and extracellular proteolysis. The present study was done to investigate the therapeutic potential of polymerase enzyme in modulating the changes occurred between levels of Tissue- type plasminogen activator (t-PA) and its inhibitor (PAI-1) in patients with multiple sclerosis. A pilot study was carried out on a total of twenty-one patients (17 females, 4 males; aged 22-46 years) with demyelination suggestive of MS and clinically silent T2 brain lesions on magnetic resonance imaging (MRI).
View complete article: PDF  |  Full-text

Treatment of vitamin D deficiency in children and adolescents

Both high prevalence of poor vitamin D status and obesity in children and adolescents are known health problems, but there is not enough information about adequate dose of vitamin D to treat these children.
View complete article: PDF  |  Full-text

Development of the Analytical Model for the Assessment of the Efficiencies of Different Therapeutic Modalities in Leukemia

Different therapeutic regimes like chemotherapy, cytokine based immunotherapy and/or stem cell transplantation are generally be the suggested options for treatment of leukemia. However, the selection of the best therapeutic strategy for an individual patient remains uncertain till now
View complete article: PDF  |  Full-text

Lip Cancer: Epidemiologic, Clinical, Evolutive, and Therapeutical Aspects

Lip cancer is relatively common, despite the progress seen recently in Morocco in terms of labial-jugal cancer reconstructions. Lip cancer is often seen in advanced stages and poses management problems.
View complete article: PDF  |  Full-text

A New Bi-Functional Derivative of Polyethylene Glycol as Molecular Carrier for Eugenol and Ibuprofen

Eugenol (EU) and ibuprofene (IBU) were covalently bound to a bi-functionalized PEG, used as molecular carrier of drugs and the release kinetics of the two bioactive molecules was studied in vitro in buffer solution at pH 7.4, in simulated gastric fluid and in mouse plasma.
View complete article: PDF  |  Full-text

Phase II Trial of Lower Dose Bevacizumab and Irinotecan in Relapsed High Grade Gliomas

Relapsed high-grade gliomas (HGG) respond poorly to known chemotherapeutic agents with a median survival of 3 to 6 months. Several phase II trials of Bevacizumab for salvage therapy, reported excellent response rates. The optimal dose of Bevacizumab in GBM has not been defined to date. We performed a prospective phase II trial of bevacizumab using 5 mg/kg every 2 weeks.
View complete article: PDF  |  Full-text

Methadone and Torsade De Pointes in the Therapeutic Range

Methadone, a long-acting opioid agonist, binds to and occupies mu-opioid receptors, preventing withdrawal symptoms for 24 hours or longer, reduces craving for opioids, and, by maintaining high levels of opioid tolerance, reduces the euphoric effects of subsequent illicit opioid use. As a controlled substance with potential for abuse, methadone use is regulated in the US and other countries.
View complete article: PDF  |  Full-text

Therapeutic Hypothermia Still Effective in Prevention of Anoxic Encephalopathy following Extended Period of Pulselessness during Cardiac Arrest

There are approximately 300,000 out-of-hospital cardiac arrests per year with less than 10% of those surviving. More than half of survivors suffer permanent neurologic deficits. Therapeutic hypothermia has proven effective at thwarting neurologic damage occurring in the 16-hour window following return of spontaneous circulation (ROSC). Despite recommendations by the American Heart Association (AHA), many cardiologists have been slow to implement therapeutic hypothermia. While many trials have discussed the relevance of initial rhythm and delay of cooling, there has been limited discussion of the efficacy of therapeutic hypothermia in the presence of extended pulselessness.
View complete article: PDF  |  Full-text

Esophageal Cancer and Bisphosphonates

At the beginning of 2009, Dianne Wysowski of the US Food and Drug Administration summarized 23 reports of esophageal1 cancer following alendronate use. Wysowski also noted that there had been 31 cases following alendronate use in Europe and Japan and ten cases in which other bisphosphonates had been reported as concomitant or suspect treatment.
View complete article: PDF  |  Full-text


Editorial Board Members Related to therapeutic

Ana Rita Ramalho Figueiras

Faculty of Pharmacy
University of Coimbra
Portugal

Robert Kinobe

Senior Lecturer
Physiology and Pharmacology
School of Veterinary and Biomedical Sciences
Australia

Eugene S. Kim

Associate Professor
Department of Surgery
University of Southern California
United States

KONSTANTINOS PAPAMICHAEL

Gastroenterologist
Medical School
University of Athens
Greece

YUNBO LI

Professor
Department of Pharmacology
Campbell University School of Osteopathic Medicine
United States

Marc Poirot

Research Director at INSERM
Cancer Research Center of Toulouse
University of Toulouse
France

ALFRED SZE-LOK CHENG

Associate Professor
School of Biomedical Sciences
The Chinese University of Hong Kong (CUHK)
China

Nikolić Dragan M

Faculty of Medicine
University of Belgrade
Serbia

Ibrahim El-Sherbiny

Associate Professor
Department of Nanomaterials Science
University of Science and Technology
Egypt

Avinash Shankar

Chairman
National Institute of Health & Research
Warisaliganj (Nawada), Bihar
India
Submit Manuscript


Open Access Journals

View All Journals