Articles Related to toxin

There is presented intrasphincetric injection management of achalasia, an esophageal dysmotility disorder involving an abnormal relaxation of the lower esophageal sphincter. Botulinum toxin A is a well-described treatment for achalasia, in patients who is contraindicated others modality due to comorbidity, especially in older age. We describe a case of a successful treatment of achalasia in the 83-old man with botulinum toxin A, as efficacy and very safe method for symptomatic relieve of these patients.

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For the investigation of micromycetes-contaminants in children foods and their toxigenic activity, 173 samples of children foods traded in local markets in al-Hasakah governorate -northeastern Syria- were collected and tested during the period (2011-2012). The tested samples were included in 4 food groups: oily seeds (35 samples), potato & maize chips (53 samples), biscuits (45 samples) and powdered milk & sugars (40 samples).The Sample investigation was undertaken in the plant diseases laboratory in Al-Qamishli Agricultural Research Center. The results of the analysis showed that most of the samples tested were contaminated with fungi in varying degrees ranged between 1× 10² and 5×10⁷ spore / gram of food substance. Only 2.3% of the samples tested exceeded 10⁴ spore / gram of food substance.

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A fucoidan with high ester sulfate content (38-40% by weight) has been isolated in a commercial scale process from Laminaria hyperborea harvested from the western coast of Norway. This is the first characterization of a fucoidan from this species of macroalgae. Ultra purified samples with negligible endotoxin levels were evaluated for cytokine expression in cultured human mononuclear cells.

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In China, the scorpion Buthus martensii Karsch is used as functional food and medicinal materials. The scorpion, scorpion venoms and their extracts are effective in treating a variety of nervous system diseases such as epilepsy, apoplexy pains and facial paralysis.

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BOTULISM is a neuro-paralytic intoxication illness caused by the ingestion of neurotoxins of Clostridium botulinum with contaminated water or food. The Gram-positive spore-producing bacterium Cl. botulinum is found worldwide and can survive in spore form for up to 30 years in numerous substrates in the environment. Cl. botulinum is classified into 7 or 8 different types (A, B, C (C1, C2), D, E, F, G) depending on the antigen properties of the botulinum neurotoxins (BoNT) produced, with intoxication mostly appearing in cattle following the ingestion of neurotoxins of type C and D and, less frequently, of type B.

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Scientists began developing and publishing a series of best practices to mitigate laboratory risks in the 1970’s. These biosafety guidelines are disseminated by the Department of Health and Human Services in the publication Biosafety in Microbiological and Biomedical Laboratories (BMBL).

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