Articles Related to type 2 diabetes
Effectiveness of a Brief Diabetes Risk Assessment Instrument for Detecting Undiagnosed Type 2 Diabetes Among High-Risk Ethnic Communities in West Africa
With the growing burden of type 2 diabetes (T2D) and associated health, social, and economiccosts in sub-Saharan Africa, tools are needed to assess T2D risks rapidly, allowing for targeted early intervention. The objective of this study was to assess the effectiveness of a brief diabetes risk assessment instrument for detecting undiagnosed Type 2 Diabetes among high-risk ethnic communities in Benin, West Africa.
Comparative Effect of a High Fat with or without High Levels of Sucrose Diets on Peripheral Neuropathy in C57BL/6J Mice
Feeding mice a diet containing high fat and high sucrose has been promoted as a good model for type 2 diabetes. This study sought to determine the effect of feeding mice a high fat and high sucrose diet on neuropathy compared to mice fed only a high fat diet and mice fed a high diet and treated with streptozotocin.
The Effects of Vitamin D on Obesity, Insulin Resistance and Type 2 Diabetes
Vitamin D is a fat-soluble vitamin. It is also referred to as a steroid hormone with an active form that can bind to receptors. The main way
to obtain vitamin D is its synthetization on the skin with the effect of ultraviolet light. It is activated in the body by two hydroxylation
reactions in the liver and kidneys. Vitamin D is said to have other effects besides those on the bone metabolism. Vitamin D deficiency is
a global social health problem. It is associated with cardiovascular diseases, obesity, metabolic syndrome, type 2 diabetes, various types
of cancer, immune deficiencies and increased mortality. It is frequently observed in obese individuals. A possible molecular mechanism
of the relationship between obesity and vitamin D deficiency may be associated with the metabolism in mature adipocytes, oxidative
stress, inflammation and the gene expression regulation capacity of vitamin D which is related to the adipogenesis process. Vitamin D
may lead to an increase in insulin secretion and a decrease in insulin resistance by regulating the immune system. Inflammatory cytokine
production is thought to be one of the mechanisms of action of vitamin D on insulin resistance. Inflammatory cytokines appear to be
associated with obesity and insulin resistance. Low levels of vitamin D may cause disruption of insulin secretion. Vitamin D may be
involved in β-cell secretion activity and changes in tissue response to insulin. There is a relationship between inadequate 25(OH)D levels
and β-cell dysfunction. Vitamin D may have beneficial effects on β-cell function by suppressing the renin-angiotensin system. Based on all
this information, it may be concluded that vitamin D is associated with obesity, insulin resistance and diabetes, and vitamin D deficiency
may form the basis for these conditions.
Fuel Metabolism Following 3 Days on a Carbohydrate-Free Diet vs. 3 Days of Fasting in Men with Type 2 Diabetes: A Randomized Controlled Crossover Trial
A 72-h fast results in a rapid decrease in circulating glucose to a lower level without a change in non-water body mass. Several metabolic adjustments are necessary. A nutrient-sufficient, carbohydrate (CHO)-free diet also has been reported to result in a decrease in glucose, and similar metabolic perturbations. However, direct comparisons are not available in subjects without, or with, type 2 diabetes (T2DM).
Selenium Supplementation in Obese Patients with Subclinical Hypothyroidism and Type 2 Diabetes
Selenium (Se) is a trace element present in many foods. Selenium-protein co-factor plays a critical anti-oxidant and anti-inflammatory role in thyroid function, but quite recently its ability to prevent adipocyte hypertrophy and adipogenesis has also been evaluated. The aim of our study was to assess whether thyroid function, as well as, body mass index (BMI) and body composition might improve in Se-treated obese patients as compared to those getting placebo (P).
Association between Insertion/Deletion Polymorphism of ApoB Gene with Dyslipidemia and Obesity Risk in Patients with Type 2 Diabetes
Several studies have suggested that Insertion/Deletion polymorphism of ApoB gene is associated with obesity, dyslipidemia, diabetes and coronary heart disease (CHD).
How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?
To develop a valid method to identify insulin resistance (IR) in overweight and obese adolescents without requiring a fasting blood sample.
Healthy and Unhealthy Dietary Patterns are related to Lipid Parameters in Patients with Type 2 Diabetes Mellitus
The effects of a single food or nutrient on disease may be insufficient and poor, but the cumulative effect is detectable. The purpose of this study is to determine the relationship between dietary patterns and lipid parameters in patients with type 2 diabetes.
Anthropometric Predictors for Multiple Risk Factor Aggregation in Adults from Maracaibo City
There are several anthropometric measures that are useful for diagnosis obesity and also are related to the development of different cardiovascular risk factors. The purpose of this study was to determine the predictive ability of various anthropometric parameters for the multiple risk factors aggregation (MRFA) in the adult population of the city of Maracaibo-Venezuela.
Stability Analysis of Human Islet Amyloid Polypeptide and Its Mutated Oligomeric Forms
Human islet amyloid polypeptide (hIAPP), a 37 residue peptide hormone is an ingenious factor in pancreatic amyloid deposits found in cases with type-2 diabetes. Its aggregation into small toxic oligomeric species is presumed to be the reason for cells debilitation and demise in case of diabetic patients.
Pharmacokinetics, Biotransformation, Distribution and Excretion of Empagliflozin, a Sodium-Glucose Co-Transporter (SGLT 2) Inhibitor, in Mice, Rats, and Dogs
The metabolism, pharmacokinetics, excretion and distribution of a sodium-glucose co-transporter (SGLT 2) inhibitor, empagliflozin, were studied in mice, rats and beagle dogs following a single oral or intravenous administration of [14C]-empagliflozin. Empagliflozin was well absorbed in all species after oral administration.
The Association of Grades of Photoreceptor Inner Segment-Ellipsoid Band Disruption with Severity of Retinopathy in Type 2 Diabetes Mellitus
A prospective case-control study was undertaken to evaluate the association of inner segment-ellipsoid (ISel) band disruption with severity of diabetic retinopathy on spectral-domain optical coherence tomography. ISel disruption was graded as - grade 0: intact ISel; grade 1: focal disruption (subfoveal ISel disruption) and grade 2: global disruption (ISel disruption involving macular cube). Increased severity of diabetic retinopathy was found to be associated with increase in disruption of ISel (r = 0.49, p < 0.001).
Editorial Board Members Related to type 2 diabetes
Weibin Shi
Associate Professor
Radiology and Biochemistry & Molecular Genetics
University of Virginia
United States
Radiology and Biochemistry & Molecular Genetics
University of Virginia
United States
Chong Lee
Associate Professor
School of Nutrition & Health Promotion
Arizona State University
United States
School of Nutrition & Health Promotion
Arizona State University
United States
Sheila Barrett
Assistant Professor
Department of Nutrition
Northern Illinois University
United States
Department of Nutrition
Northern Illinois University
United States
Liqing Yu
Associate Professor
Departments of Animal and Avian Sciences
University of Maryland
United States
Departments of Animal and Avian Sciences
University of Maryland
United States
XU-FENG HUANG
Professor
School of Health Sciences
University of Wollongong
Australia
School of Health Sciences
University of Wollongong
Australia
Jamie I. Baum
Assistant Professor
Department of Food Science
University of Arkansas
United States
Department of Food Science
University of Arkansas
United States
Kenneth Cheng
Assistant Professor
Department of Medicine
Hong Kong University
Hong Kong
Department of Medicine
Hong Kong University
Hong Kong
Josep Bassaganya-Riera
Professor
Virginia Bioinformatics Institute
United States
Virginia Bioinformatics Institute
United States
KEQUAN ZHOU
Associate Professor
Department of Nutrition & Food Science
Wayne State University
United States
Department of Nutrition & Food Science
Wayne State University
United States
Edralin A Lucas
Associate Professor
Department of Nutritional Sciences
Oklahoma State University
United States
Department of Nutritional Sciences
Oklahoma State University
United States