My scientific training has been multidisciplinary (medicine, basic research in biology, and computer science). My ongoing research projects bring together the fields of bioinformatics and cancer biology. My primary interest is to elucidate molecular mechanisms of disease using high-throughput functional genomic approaches.
More specifically, I have developed large-scale databases of gene expression signatures related to human cancer and developed a strategy to perform meta-analyses of gene expression profiles from published cancer studies and the TCGA project. The results from data mining of gene expression signatures have helped us identify prognostic and predictive signatures and novel candidate metastasis-regulatory genes in cancer. I have further investigated one intriguing candidate gene in my lab by in vivo and in vitro functional approaches.
