Advancing Scientific Research Through Open Access

Oral submucous fibrosis (OSMF) is a chronic, progressive, and potentially malignant disorder of the oral cavity characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the lamina propria and deeper connective tissues, leading to stiffness of the oral mucosa and limitation of mouth opening. The condition is predominantly reported in South and South east Asian populations and is strongly associated with the habitual use of areca nut, betel quid, and tobacco products [1, 4]. Clinically, OSMF presents with burning sensation of the oral mucosa, blanching, formation of fibrotic bands, intolerance to spi cy food, and progressive trismus [2, 3]

Serum protein electrophoresis (SPE) is an informative test primarily used to detect abnormalities in the gamma region, particularly to identify monoclonal immunoglobulins (M- proteins) in multiple myeloma (MM). MM is the second most common hematologic cancer, mainly affecting adults over 65. This study presents SPE results from routine laboratory check- ups in healthy Bulgarian adults.

People Living with HIV (PLHIV) have a higher risk of mental health issues than the public. HIV and related infections can affect the brain and the rest of the nervous system. This may change how a person thinks and behaves. In addition, some medications used to treat HIV may have side effects that affect a person's mental health [1]. HIV causes significant inflammation in the body. This inflammation can cause neurological complications by damaging the spinal cord and brain, which form the central nervous system. Despite effective Antiretroviral (ART), people with HIV are still at risk for central nervous system diseases associated with HIV. These diseases can be neurological (affecting the nervous system) or neurocognitive (affecting cognition or mental processing).

Age related changes in combination of voice and swallowing are often unaddressed in geriatric population. The study highlights the coexistence of presbyphonia and presbyphagia. Early diagnosis and providing appropriate intervention strategies can help improve the individual’s quality of life.

The results of the HER2-Positive Advanced Breast Cancer trial presented by Dr. Sara M. Tolaney at the ASCO Annual Meeting 2025, shows a promising new treatment for metastatic HER2-positive breast cancer. The study found that using T-DXd with pertuzumab nearly doubles how long patients can control their disease compared to the standard treatment, THP.1.

The results highlight the notetaking findings from the PISCES trial conducted by Dr. Charmaine E. Lok, who studied the impact of fish-oil supplementation on cardiovascular diseases among the haemodialysis patients. Between November 28, 2013, and July 22, 2019, 1,228 participants were under randomized case-study, with 610 assigned to the fish-oil group and 618 to the placebo group [1]. Over a follow-up period of 3.5 years, results showed a noticeable lower rate of serious cardiovascular diseases in the fish-oil group (0.31 vs. 0.61 per 1000 patient days), providing a hazard ratio of 0.57 (95% CI, 0.47 to 0.70; P<0.001) [2].