Journal of Pharmaceutics & Drug Development

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Highlights

Research Highlights

General practitioners' perceptions on home medicines reviews: a qualitative analysis

Home Medicines Review (HMR) is an Australian initiative introduced in 2001 to improve quality use of medicines. Medication management services such as HMRs have the potential to reduce medication related problems.

Enhancing Tissue Engineering/Regenerative Medicine Product Commercialization: The role of science in regulatory decision making for TE/RM product development

In 2010, the TERMIS-AM Industry Committee (TERMIS-AM/IC) began to delineate potential opportunities to enhance commercialization of products highlighted by the TERMIS constituency.

Pembrolizumab Cutaneous Adverse Events and Their Association With Disease Progression

Immunomodulatory anticancer drugs, such as the anti-programmed death-1 drug pembrolizumab, have shown promising results in trials, and more patients will receive such treatments. Little is known about cutaneous adverse events (AEs) caused by these drugs and their possible correlation with treatment response.

Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation

Careful design of nanoparticles plays a crucial role in their biomedical applications. It not only defines the stability of nanoparticles in a biological medium but also programs their biological functionality and specific interactions with cells.

Association of metabolic complications with plasma mid-regional pro-adrenomedullin level in stable kidney transplant recipients

Recently, increased plasma mid-regional pro-adrenomedullin (MR-proADM) concentrations have been demonstrated in patients with chronic renal failure. In this study, we attempted to identify significant clinical factors associated with MR-proADM concentration in stable kidney transplant recipients.

New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr-/- mice

Peroxisome proliferator-activated receptor gamma (PPARγ) regulates multiple pathways involved in the pathogenesis of obesity and atherosclerosis. Here, we evaluated the therapeutic potential of GQ-177, a new thiazolidinedione, on diet-induced obesity and atherosclerosis.

Endothelial Dysfunction and Vascular Disease - A Thirthieth Anniversary Update

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium-derived relaxing factor (EDRF) is nitric oxide (NO) which activates soluble guanylyl cyclase in the vascular smooth muscle cells, with the production of cyclic huanosine monophosphate (cGMP) initiating relaxation.

An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells

Drug delivery to the oral cavity poses a significant challenge due to the short residence time of the formulations at the site of action. From this point of view, nanoparticulate drug delivery systems with ability to adhere to the oral mucosa are advantageous as they could increase the effectiveness of the therapy.

Synthetic zeolites as controlled release delivery systems for anti-inflammatory drugs

Scientists have always been trying to use artificial zeolites to make modified release drug delivery systems in the gastrointestinal tract. An ideal carrier should have the capability to release the drug in the intestine, which is the main area of absorption. Zeolites are mineral aluminosilicate compounds with regular structure and huge porosity, which are available in natural and artificial forms.

Elastin-like polypeptides in drug delivery

The use of recombinant elastin-like materials or elastin-like recombinamers (ELRs), in drug-delivery applications is reviewed in this work. Although ELRs were initially used in similar ways to other, more conventional kinds of polymeric carriers, their unique properties soon gave rise to systems of unparalleled functionality and efficiency.

Pharmacological characterization of a novel gastrodin derivative as a potential anti-migraine agent

Migraine is a highly prevalent neurovascular disorder in the brain. An optimal therapy for migraine has not yet been developed. Gastrodin (Gas), the main effective constitute from Gastrodiae Rhizoma (Tianma in Chinese), has been indicated for migraine treatment and prophylaxis more than 30years, with demonstrated safety.