Dr. Dagmara McGuinness current interests include the epigenetics of disease and normal tissue, with a focus on transplantation and renal function. Her current research has demonstrated the ability of various classes of non-coding RNAs including microRNAs and lncRNAs, measured pre-transplant, to predict post-transplant outcomes in renal transplant patients. This methodology has also shown some potential for differentiating serum/tissues samples from cancer patients and those from non-cancer patients. Recently this has involved demonstrating the effects of socio-economic factors and environmental toxins on epigenetics and pre-disposition to disease and accelerated ageing. Furthermore, her research has demonstrated that global methylation is influenced by socio-economic factors and this alteration may results in a higher risk for specific diseases. Recently, she have also demonstrated the involvement of the CDKN2A locus in the accelerated ageing phenotype associated with viral infections, including HCV and HIV
Her research interests includes
