Dr. Jonathan Keller obtained his Ph.D. at George Washington University, Washington, D.C., where he characterized and purified interleukin 3. He is currently a Principal Investigator in the Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Md, where he is the Head of the Hematopoiesis and Stem Cell Biology Section in the Mouse Cancer Genetics Program. He is also an Adjunct Professor in the Genetics Department at the George Washington University, Washington, D.C. He has authored numerous manuscripts, holds three patents, and has received awards for his scientific accomplishments in the area of molecular and cellular regulation of hematopoietic cell growth and differentiation.
Dr. Jonathan Keller has a long standing interest in defining the molecular and cellular regulation of hematopoiesis. He characterized and purified interleukin 3, one of the first growth factors that regulate hematopoietic stem cell (HSC) development. He discovered that the proliferation of HSC is balanced by the action of negative growth regulators including transforming growth factor-β. His laboratory is currently focused on understanding how transcription factors regulate HSC quiescence, survival, self-renewal, and cell fate, and how they are integrated into wider transcription factor regulatory networks that regulate HSC development.
Dr. Jonathan Keller's areas of expertise includes: 1) Stem Cell Biology 2) Hematopoiesis 3) Transcription Factors 4) Hematopoietic malignancies 5) Molecular regulation of self renewal and cell fate 6) Bone marrow transplantation.
