The major goal of Dr. Lacorazza’s group is to better understand the molecular control of normal and malignant hematopoiesis, including development and differentiation of CD8+ T cells. His group studies genes involved in the balance between quiescence, a non-proliferative state poised to re-enter the cell cycle, and differentiating proliferation in hematopoietic stem cells and naïve/memory CD8+ T cells. Dr. Lacorazza also investigates the role of these genes in the pathobiology and targeted therapy of pediatric acute lymphoblastic leukemias and the chemoresistance of leukemic stem cells.
