Journal of Proteomics and Genomics

Dr. Hong-Wen Deng have extensive inter-disciplinary research experience, as PI, on several successfully administered and implemented NIH grants.He had all the necessary expertise to direct this project. He published >400 peer-reviewed papers, many of them in top journals. He assembled a multidisciplinary team of long-time collaborating investigators with strong complementing experience.

Research: Dr. Hong-Wen Deng interested in developing novel statistical methods and bioinformatics tools for analyzing and managing large, complex datasets in genomic and epigenomic research and expertise in genomics, functional genomics, proteomics, epigenomics, molecular genetics, bone biology, bioinformatics, statistical genetics, and clinic and translational research.

Research: Single-cell drug transport: uptake and efflux Study of drug action on cancer based on intracellular measurement. Microfluidic microarray DNA/RNA hybridization for pathogen detection Microfluidic microarray detection of protein biomarkers microfluidic reactor chip-based radiotracer compound production 

Dr. Sridhar Mani has a longstanding interest in drug discover and has been intensely involved in multi-disciplinary research involving several aspects of drug discovery.  He has published extensively in significant peer-reviewed journals and values collaboration as a means to solving vexing clinical and scientific questions.

Research: Dr. Sridhar Mani is interested in the role of orphan nuclear receptor research in human health and disease, with a focus on xenobiotic metabolism.  In addition to drug metabolism, Dr. Mani is broadly interested in how these receptor systems control human health and disease in general.

Dr. Liu received his medical degree in clinical medicine from Capital Medical University in Beijing, China. He completed his PhD in biomedical sciences from Creighton University in Omaha, Nebraska. Dr. Liu completed postdoc studies in Statistical Genetics from University of Alabama, in Birmingham, Alabama. He is currently an associate professor in the department of biostatistics and bioinformatics at Tulane University School of Public Health and Tropical Medicine.

Research: Dr. Liu research interests include gene identification and functional studies for complex human diseases (such as obesity, osteoporosis cardiovascular diseases and sacropenia) using molecular genetics technologies and statistical genetics methods.

Research: Microtubule-drug interactions: A major focus of his research is to elucidate structural changes in the dynamics of tubulin/microtubule interactions with endogenous microtubule associated proteins (MAPs) and antitumor drugs in order to inform biological mechanisms and patient care. Hydrogen-deuterium exchange (HDX) and Mass Spectrometry (MS) has been used to examine drug-microtubule-protein interactions. Metabolite function discovery: With the enormous successes that have been realized in high-throughput genome sequencing, major opportunities and challenges now exist in the areas of functional annotation and metabolite discovery. He had observed that approximately 3-5% of the structures deriving from E. coli-expressed material contain a non-metal ligand that has persisted through purification and crystallization. His interest is to utilize the inherent mass accuracy and efficiency of high-resolution mass spectrometry to develop a unique pipeline for metabolite discovery and functional annotation. 

Research: Mass spectrometry, Proteomics-based system biology, Biomarker discovery, Protein posttranslational modifications analysis, Discovery and quantitation of neuropeptides, Neuropeptidomics, Proteomics and bioanalysis methodology.

Dr Grant Dewson obtained his PhD from the University of Leicester (UK) in 2002 studying the molecular mechanisms of eosinophil persistence in asthma. Following a post-doctoral position investigating chronic lymphocytic leukemia with Prof. Gerry Cohen at the Medical Research Centre Leicester, in 2003, he joined Dr Ruth Kluck at the Walter and Eliza Hall Institute to investigate the basic mechanisms of apoptotic cell death. He became an Australian Research Council fellow in 2005 and an ARC Future Fellow in 2010. In 2011 he joined Prof. David Vaux in the Cell Signalling and Cell Death Division at WEHI as laboratory head. His group utilises multi-disciplinary approaches to clarify the molecular mechanisms regulating apoptosis and mitochondrial dynamics with the ultimate aim of identifying therapeutic avenues to augment or inhibit apoptosis in diseases including cancer, neurodegeneration and stroke.

Research: Elucidating how Bak and Bax are activated in response to apoptotic stimuli Understanding how Bak and Bax damage mitochondria to cause cell death

Dr Fairlie obtained his PhD from Monash University, Victoria, Australia in 1994. Subsequently, he did postdoctoral stints at the State University of New York, Buffalo (USA) and the Centre for Immunology, Sydney, Australia, before relocating to Melbourne to work in the Cancer and Haematology Division at the Walter and Eliza Hall Institute of Medical Research. He is currently a Laboratory Head in the Structural Biology Division at the Walter and Eliza Hall Institute.

Research: Cell death regulation Drug development Protein structure/function analysis X-ray crystallography

Dr. Khalid Ul Rehman Hakeem is presently working as an Associate Professor in Faculty of Forestry at Universiti Putra Malaysia, Malaysia. He is also Visiting Scientist in Department of Biology, Faculty of Science Fatih University, Turkey. He has almost more than 40 publications under his name. He had published more than 20 Book chapters. He also had more than 10 books in his name. He also gave more than 20 oral presentations internationally. He had attended more than 20 International Conferences and Workshops. He is also Editorial Board member for many International Journals.

Research: His research interests are Plant Molecular biology (particularly Genomic & Proteomic analysis) Plant Eco-Physiology Pollution research Environmental Ecological and Forestry studies

Desheng Pei, Ph.D, the professor, and the recipient of “Hundred Talents Program” of Chinese Academy of Sciences (CAS), and the dean of Research Center for Environment and Health (RCEH), Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences (CIGIT, CAS). Dr. Pei got his Ph.D. degree from Institute of Hydrobiology, Chinese Academy of Sciences (IHB, CAS) in 2003. From Jun 2006 to Feb 2009, Dr. Pei worked on the Center of Aquatic Environment and Human Health in IHB as an assistant professor. From Feb. 2009 to Feb. 2011, as a Senior Postdoctoral Research Associate, Dr. Pei concentrated his study on the mechanisms of DNA damage and repair in Northeastern University. Thereafter, Dr. Pei worked as Research Fellow in Dana-Farber Cancer Institute/Harvard Medical School to study on the mechanism of carcinogenesis of neuroblastoma from Feb. 2011 to Feb. 2013. His discoveries have been published in PLOS Genetics, Nucleic Acids Research, Cancer Cell, BMC Development Biology, Theriogenology, Analytical Biochemistry and Development Dynamics, etc.

Research: Development of novel monitoring methods on environmental pollutants; the mechanisms of toxicology and carcinogenesis of environmental pollutants. 

Prof. Hon-Ming Lam, a Hong Kong native, obtained his Ph.D. degree (Molecular Biology and Biochemistry) from Northwestern University in the USA in 1992. He received further postdoctoral training at New York University (1992-1996) in the field of plant molecular biology. In 1997, he returned to Hong Kong to join The Chinese University of Hong Kong. He is currently the director of Molecular Biotechnology Program and the director of the Center for Soybean Research at The Chinese University of Hong Kong. Prof. Lam made significant contributions in plant molecular biology especially in nitrogen metabolism and amino acid signaling in the early stage of his career. He then focused his research on soybean genomics and gene functional studies. He led a project to employ whole genome sequencing approach to complete a study on the genomic diversity between wild and cultivated soybeans. Using the soybean genomic data, the goal of his team is to explore important genes/alleles from unique soybean germplasm and apply them to crop improvement programs, especially in the enhancement of stress tolerance.

Research: Genomic and gene functional analysis of soybean Manipulation of nitrogen sink-source relationship in higher plants Identification of new signaling components for defense response in rice

Dr. Zhao is an assistant professor with strong experience in bioinformatics, health informatics, genetic epidemiology, and molecular genetics.She obtained her Bachelor and Master Degrees from China Agricultural University, Beijing, P. R. China, and acquired her Ph.D. degree in human genetics in 2006.  Dr. Zhao has published 59 original research papers and reviews in research fields of human genetics, genetic epidemiology, bioinformatics, obesity and osteoporosis. The results of her research have been published in prestigious journals such as Journal of Medical Genetics, Human Genetics, Journal of Bone and Mineral Research, Bone, Osteoporosis International, Journal of Clinical Endocrinology and Metabolism. 

Research: Lan-Juan  research interest is in human genetics study in complex disease, such as osteoporosis, osteoporotic hip fracture, sarcopenia, and obesity.

Dr. Yin received her undergraduate degree in chemistry from Peking University, China, and obtained her Ph.D. degree in Molecular Biology and Genetics from Cornell University in 2001. She joined the Lead Discovery Department at Genomics Institute of the Norvartis Research Foundation (GNF), San Diego for high throughput drug discovery and working on infectiour disease (HCV) at ItherX/Immusol (San Diego) as a research scientist. Dr. Yin joined Translational Genomics Institute at Phoenix, AZ (TGen) as the head of Cellular Genomics Center in 2005, where she established a state-of-art high throughput screening facility. 

Research: Dr. Yin research interests mainly focused on applying high throughput functional genomics and/or compound screening technologies in novel target and/or drug identification, understanding in drug resistance, and clinical compound improvement.  

Dr. Huaizhen Qin is an assistant professor, holding a PhD degree in Theoretical Statistics and a PhD degree in Mathematical Sciences. His career goal is to develop efficient solutions for timely and important data analytic problems in Biology Sciences and foster next-generation Biostatisticians.He have formally digested extensive knowledge of and made major research efforts in Next-generation sequenc-ing, Genetic Epidemiology, Statistical Genetics, Microarray Experiments, Econometrics and Survey Sampling. He have been involved in developing statistical methods and computa-tional toolkits (1) for identifying susceptibility genetic variants of complex human diseases, (2) for ana-lyzing microarray data in small- and large-replicate experiments, (3) for addressing sensitivity analysis in econometrics and (4) for designing nationwide surveys.

Research: Statistical genetics, computational biology, causal inference, survey sampling

Dr. Elena Kolomietz received her medical degree from the State Medical Academy, St. Petersburg, Russia and her PhD in Genetics from the University of Toronto in 2002. Dr. Kolomietz is a Fellow of the Canadian College of Medical Geneticists and American College of Medical Geneticists. She joined the staff of the Department of Pathology and Laboratory Medicine at Mount Sinai Hospital in 2004 and is currently the Co-Head of the Division of Diagnostic Medical Genetics in the Department of Pathology and Laboratory Medicine at Mount Sinai Hospital. She is also an Assistant Professor in the Department of Laboratory Medicine and Pathobiology at the University of Toronto. Dr. Kolomietz received several awards, including Governor-General Fellowship Award, Leukemia Research Fund of Canada in 2001. 

Research: The major focus of my research is the development and application of genomic technologies to the understanding of the causes of reproductive failure. Identification and characterization of copy number variation in infertile males, preimplantation embryos and perinatal samples provide insight into the mechanisms that cause infertility and abnormal embryonic development.

Dr. Andrew Percy received his PhD in Bioanalytical Chemistry at the University of Calgary (Canada) in 2011.  There, he investigated the interactions of binary multicomponent complexes (protein-ligand and protein-protein) through novel bottom-up hydrogen/deuterium exchange mass spectrometric approaches and novel data analysis strategies.  His passion for proteomics led him to the UVic-Genome BC Proteomics Centre (Canada) where he completed a one year postdoctoral fellowship before becoming the laboratory co-leader of the quantitative proteomics division. 

Research: Advance targeted proteomic methodologies toward improved breadth and depth of protein quantitation. Pre-clinical verification of panels of candidate protein disease biomarkers in human biofluids.

Research: Plant development and signal transduction. Functional genomics of plant stress resistance.

Dr. Ngai has over 20 years experience in Protein/Peptide biochemistry, proteomics and computational techniques and is the author of over 60 scientific publications, 3 book chaperters and numerous conference papers. He is currently associated professsor in School of Life Sciences, Director of The Chinese Medicinal Fungal Proteomics Laboratory and Investigator of State Key Laboratory for Agrobiotechnology in The Chinese University of Hong Kong, Hong Kong SAR, China. 

Research: His research interest is bioinformatics, proteomics and metabolomics, protein/peptide structural and functional studies, and Modern Chinese Medicine.