Recent Articles

Controlling osteoarthritic pain has emerged as a major health care challenge. Available treatments are either cytotoxic or addictive and therefore there is an urgent need to develop alternative treatment options. We previously developed a liposomal-alginate construct to improve local anesthetic delivery as a potential chronic pain management treatment.

Forty patients with CHDs who received liver biopsy to stage fibrosis and 12 normal subjects performed also shear wave elastography (SWE) and ELF-test. We chose two different outcomes for histological fibrosis (F0-F1 vs F2-F4) and (F0-F2 vs F3-F4). ELF-test and SWE were independent predictors, categorized using ROC analysis. Two scores called SCORE1 and SCORE2 were devised.

3D gas-solid coupled symmetrical numerical model was developed on the basis of multiphysics finite element platform to study coal seam fracture stimulation under the high pressure gas impact loading generated by the highly pressurized multi-discharge carbon dioxide gas fracturing technique to improve pre gas drainage efficiency. The purposes of this study are to understand the natural and operational factors contribute to coal seam fracture stimulation and improvement of coal seam gas drainage efficiency and the interaction of these parameters.

From Jan –2004 to Dec-2004, five patients were referred to the surgical department with a diagnosis of endocarditis refractory to medical therapy. Patients were all male, age ranging 16 years to 28 years with a mean of 22 years. All of the five patients had native valve endocarditis of the tricuspid valve with a history of drug addiction in common. Their presentations included, sepsis, failure and recurrent pulmonary embolism. Three of them had bacterial, while two had fungal infection which was proven after blood cultures. After resuscitation, stabilization and preoperative workup, tricuspid valvectomy was performed on these patients because of the destructive and irreparable nature of the native valve. Fortunately, all had uneventful recovery after surgery. Pre-operatively these patients were treated with antibiotics and antifungals, and continued thereafter for almost 4 to 6 weeks in the post-operative period. Postoperatively there was significant tricuspid regurgitation in a subset of patients who had a follow-up. The Left Ventricular (LV) function remained normal to moderate with a moderate pulmonary artery pressure. These patients were discharged on antibiotics and anti-failure medications as per the GDMT.

Donepezil is a potent, selective, noncompetitive and reversible inhibitor of acetylcholinesterase, commonly used for the treatment of Alzheimer’s disease. The form of orally disintegrating tablets (ODTs) is a good alternative dosage form for patients who have a difficulty in swallowing conventional tablets or capsules.

To investigate the association between platelet values and COPD severity using linear variables in order to better explain and explore these correlations.

The clothing industry is a field full of occupational diseases such as MSDs which are widely recognized in the wrists, hands, elbows, neck and lower back due to poor posture. Several studies have emphasized the importance of preventive actions to reduce the risk of occupational diseases.

The aim of this study is to describe clinical variables and comorbidities in patients with shock, at arrival to the emergency department, and evaluate the diagnostic validity for different shock etiologies. This was a retrospective cohort study with tertiary analysis of data previously published in two other studies. The study population was all patients with shock, arriving to the emergency department at Odense University Hospital between 2000 and 2011. Shock was defined as systolic blood pressure ≤100mmHg and one or more organ failures. Patients were grouped according to discharge diagnoses and this method was manually validated through patient records. The diagnostic value of 26 clinical variables and 10 comorbidities were described and tested.

Laryngotracheal stenosis is one of the important causes of pediatric airway obstruction, and the etiology can be classified as congenital and acquired. With the widespread use of tracheal intubation and tracheotomy in pediatric emergency, iatrogenic laryngotracheal stenosis is gradually replacing trauma and infection as the major cause of acquired laryngotracheal stenosis [1]. Nowadays, open surgery is the first choice for severe laryngotracheal stenosis cases [1,2]. Here, we describe a case of childhood iatrogenic severe laryngotracheal stenosis, and the reflection on the current treatment methods of children with laryngotracheal stenosis.

Haemangiomas are the most common benign incidentally detected hepatic lesions with a prevalence of ~20%. Most of them have typical imaging features and are easily diagnosed on triple phase studies. These are capillary, flash and giant hemangioma. Another subset of haemangiomas are Sclerosing hemangiomas or atypical haemangioma; these are sclerosed, thrombosed and/or hyalinised due to which these are heterogenous and show varied appearance making them difficult to diagnose.

We report 2 cases of severe injuries in patients with sleep disorders. The first patient sustained multiple orthopedic traumas as sequelae of REM sleep behavior disorders (RBD). The second patient sustained a severe TBI as a result of restless legs syndrome (RLS). To our knowledge, there are only 2 reported cases of severe orthopedic traumas (cervical spine fractures) as a result of RBD and no reported cases of severe TBI from RLS.

We report the theoretical investigation of type-I InGaAsBi/InGaAs superlattice short-wave infrared detector nearly lattice matched to InP substrate such as the quaternary InGaAsBi/InGaAs layer is the absorption region. The used bismuth composition is about 5.5%, the Bi incorporation induced a cut-off wavelength red-shift from 1.6 µm to 3µm at room temperature (RT), and showing a band gap reduction about 362meV.

This study aims at describing the CT imaging findings and role of multidetector computed tomography (MDCT) in evaluation of squamous cell carcinoma of buccal mucosa and its staging. The imaging findings in squamous cell carcinoma (SCC) of the oral cavity allow the radiologist to accurately determine the extent and staging of disease thereby help clinicians plan appropriate treatment.

To explore the disorders in the hematological index among normotensive, prehypertensive and hypertensive patients and help detect the predictive and preventive factors of hypertension-related complications. A comparative cross-sectional study was conducted from January to December 2018 on a total of 3000 study participants classified as hypertensive (HTN, blood pressure ≥140/90 mmHg), prehypertensive (PHTN, blood pressure =120-139/80-89 mmHg), and normotensive (NTN, blood pressure

History teaches that successful vaccine development is a highly empirical process involving guesswork and tinkering, typically done in the face of woefully incomplete biological understanding. The AIDS vaccine effort effectively abandoned this classical approach early on.

The study aims to inventory the medicinal plants used in feeding, health and reproduction of rabbits. The surveys were carried out at 248 rabbit’s breeders in southern Benin. The identification of frequent species has been carried out. The ethnobotanical data were analyzed using various quantitative indices calculated for each of the medicinal plants recorded such as relative frequency of citations (RFC), informant consensus factor (ICF), relative importance index (RII), use value (UV), family importance value index (FIV), and level of fidelity (FL).

In newborns, vomiting is a very frequent find. Especially in a newborn who has undergone major surgery, postoperative vomiting is a common occurrence. In our study, we aimed to present a newborn who was operated on first for anorectal malformation (ARM) and then for vesicoureteral reflux (VUR) and diagnosed with infantile hypertrophic pyloric stenosis (IHPS) upon persistent vomiting

Lack of degradability and the closing of landfill sites as well as growing water and land pollution problems have led to concern about plastics. In the past few decades, the use of plastics has enormously increased, mostly used for food packaging. Ironically, the most preferred property of plastics – durability – exerts also the major environmental threat. With the excessive use of plastics and increasing pressure being placed on capacities available for plastic waste disposal, the need for biodegradable plastics and biodegradation of plastic wastes has assumed increasing importance in the last few years.

Fluoxetine Hydrochloride (FH), a selective serotonin reuptake inhibitor (SSRI) is a drug of choice in depression, obsessive-compulsive disorder (OCD), bulimia nervosa, etc. Though tablet, capsules, oral solution, or syrup are currently available conventional dosage form of FH, modified or immediate-release formulations for fast onset of action is of utmost importance.

The case was a 7-year-old girl who had complained of bilateral blurry vision for 1 week. Five weeks earlier, she suffered from a flu-like episode with fever, sore throat, and skin rash, and received an irregular dose of oral amoxicillin for 4 days after a diagnosis of scarlet fever. Our clinical examination revealed bilateral panuveitis with frosted-branch angiitis.