PubMed Indexed Articles

The results of the HER2-Positive Advanced Breast Cancer trial presented by Dr. Sara M. Tolaney at the ASCO Annual Meeting 2025, shows a promising new treatment for metastatic HER2-positive breast cancer. The study found that using T-DXd with pertuzumab nearly doubles how long patients can control their disease compared to the standard treatment, THP.1.

The results highlight the notetaking findings from the PISCES trial conducted by Dr. Charmaine E. Lok, who studied the impact of fish-oil supplementation on cardiovascular diseases among the haemodialysis patients. Between November 28, 2013, and July 22, 2019, 1,228 participants were under randomized case-study, with 610 assigned to the fish-oil group and 618 to the placebo group [1]. Over a follow-up period of 3.5 years, results showed a noticeable lower rate of serious cardiovascular diseases in the fish-oil group (0.31 vs. 0.61 per 1000 patient days), providing a hazard ratio of 0.57 (95% CI, 0.47 to 0.70; P

Different methods are nowadays employed for the preservation of postharvest fruits quality, such as chemical treatments, heating and freezing. However, the application of these methodologies often causes heavy losses during storage, due to pathogenic microorganisms’ and insects’ activity.

Background: Lower respiratory tract infections (LRTIs) frequently require immediate empirical antibiotic therapy due to di agnostic delays and clinical severity. Empirical regimens commonly rely on broad-spectrum agents, which can increase selec tive pressure for antimicrobial resistance.

The global rise in obesity presents a significant public health challenge, with implications extending beyond metabolic disor ders to include an increased risk of cognitive decline and dementia.

Media strongly influences children’s eating habits, promoting consumption of sugary and ultra-processed foods.

Sub-Saharan Africa has experienced substantial declines in new HIV infections over the past decade; however, these gains have not been uniform across populations. In Mozambique, married women remain a largely overlooked group in HIV prevention strategies, despite persistently high HIV prevalence.

Maternal insufficient calcium consumption can raise the risk of pregnancy-related problems such preeclampsia and gestational hypertension, which are linked to considerable morbidity and mortality in both the mother and the newborn.

Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy that may arise de novo or secondary to cytotoxic therapies. Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i), such as palbociclib, ribociclib, and abemaciclib are widely used in the treatment of hormone receptor-positive breast cancer (HR+BC) and have a tolerable safety prole compared to conventional chemotherapy agents applied in this space.

Objective: This systematic review aimed to evaluate the effectiveness of yoga as a therapeutic intervention for reducing anxi ety symptoms, improving comorbid depression and somatic complaints, and enhancing quality of life in adults with Gener alized Anxiety Disorder (GAD). Methods: A systematic search of PubMed and CINAHL was conducted up to August 2025. The review was registered in PROSPERO (CRD420251152980). Eligible studies included randomized controlled and clinical trials evaluating yoga inter ventions in adults diagnosed with GAD based on DSM criteria. Data extraction focused on intervention type, outcomes, and treatment effects. Risk of bias was assessed using Joanna Briggs Institute (JBI) tools, and results were synthesized narratively due to heterogeneity

Abstract: Umbilical cord blood contains stem cells which are useful in chemotherapy, implantation; however, cord RBC is considered as a waste product. It is necessary to use the umbilical cord blood for neonatal blood transfusion to avoid diseases. Nowadays, nanoparticles are used in biomedical and pharmaceutical industry. Nanoparticles interact with blood via different routes. In addition, these nanoparticles used in biomedicine, drug delivery, bioimaging, and to increase the shelf life of RBC. Nevertheless, research of nanoparticle interaction with umbilical cord red blood cells is still . in the present study, interaction between umbilical cord blood-RBC and citrate-stabilized gold nanoparticles is studied. Methods: Umbilical cord rbc isolated from whole blood immediately r the collection using centrifuge. PBS r is used as a physiological media and washing reagent. interaction of isolated RBC (2% suspension) with t con centration of citrate stabilized gold nanoparticle were investigated using UV-Visible spectroscopy, Raman spectroscopy, and Interfacial tension measurement technique. Results: UV-Visible spectroscopy is used to investigate the changes in Soret band and oxygenation bands (Q1 and Q2). Variation in absorption intensity is observed in umbilical cord RBC incubated citrate stabilized gold nanoparticles. However, there is no t shi in Soret band and Q1, Q2 band of cord-RBC with Au nanoparticles. In case of Raman spectros copy, enhancement in disulphide band region (526 cm-1 and 579 cm-1) and change in the spin state marker is investigated. While, interfacial tension decreases for 10 �l and increases for 100 �l and 200�l of 40 nM AuNP.

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that influences how children communicate, interact so cially, and manage everyday behaviors. Although every child on the spectrum shows a different mix of strengths and chal lenges, certain patterns tend to appear reduced social reciprocity, unusual sensory responses, and, quite often, delays in language or motor skills. These characteristics seem to result from a combination of genetic and environmental factors, along with autoimmune and perinatal influences. At present, ASD affects about 1 in 44 children [1] The broader spectrum still includes what were once separate diagnoses, such as Asperger’s syndrome, PDD-NOS, Rett syndrome, and Childhood Disintegrative Di sorder [2]. Motor-related differences are frequently among the earliest signs. Children may have trouble with coordination or maintaining balance, and tasks that involve fine motor control can be more demanding than expected for their age (Bhat et al., 2011; Staples & Reid, 2010). Many also face challenges in imitation or praxis; copying a movement, judging spatial placement, or learning a new motor sequence may take more time or effort. Since these skills underpin everyday functioning and many social exchanges, such difficulties can limit both peer interaction and independence in daily life [3]. Added to this, sleep disturbances and gastrointestinal problems are common and can intensify emotional and behavioral challenges (Miano et al., 2007; Rao et al., 2008)

Glomerular filtration rate (GFR) estimation is a critical step in clinical nephrology and has important implications in clinical practice, but also in the field of epidemiology and prevention [1-4]. The measurement of GFR by a so-called reference tech nique remains fundamental but limited to specialized centers [1,5,6]. The definition of chronic kidney disease (CKD) is based, among other things, on the level of GFR and requires that it can be quickly and easily estimated [7]. In clinical practice, com monly used formulas

Abstract Background: Culture is effective in discourse analysis of spirituality. Cultural customs can destroy a secure attachment to God. Hemodialysis patients with insecure attachment to God due to fear and despair experience spiritual distress, which endangers their psychosocial health and creates the need for spiritual counseling. The aim of this study was investigation of the effect of strengthening secure attachment to God in spiritual counseling on spiritual health of hemodialysis patients. Methods: This randomized controlled trial with pre-post test, and control groups was performed in 2020 at the hemodialysis department of Kamkar Hospital in Qom for 110 patients. The Sound Heart Model–based spiritual counseling was performed in 12 sessions of 35 minutes for the intervention group. The spiritual health questionnaire was completed by both groups before and after the intervention. Independent t-test was used to compare the mean score between the two groups. The T-pair test was used to compare the change of each group. The significance level for all tests was 0.05. Data were analyzed by SPSS software version 24. Results: ere was no statistically signi cant di erence in spiritual health scores between the intervention (76.83±1.35) and control (73.43±1.41) groups, before intervention (P =0.08). A er intervention, a signi cant statistical di erence was ob served (P

We present a 2-year-old boy known case of Spinal muscular atrophy type 2 presented with acute onset quadriparesis following a trivial trauma. On admission child had flaccid quadriparesis without bladder-bowel or respiratory involvement. His blood investigations, MRI Spine and Brain were unremarkable.

End stage renal disease in patients with junctional epidermolysis bullosa (JEB) pose distinctive clinical and management challenges. Their fragile skin, frequent infections, nutritional deficiencies, and ongoing inflammation can fasten kidney deterioration. Creating and maintaining dialysis access is especially dicult in these individuals, as their delicate skin and poor wound healing often result in repeated access issues or serious complications. Here we report a case of 23 year old female who after initiation of hemodialysis started to develop blistering disease with occurrence of multiple bulla over skin and mucous membrane and faced multiple issues in creating vascular access.

Although the discovery of the V617F mutation in the JAK2 gene has modified the understanding and treatment of polycythemia vera (PV), some patients display complex characteristics not recognized in the recent 2022 WHO classification. In the case reported here, no JAK2V617F nor JAK2 exon 12 mutations were identified

Penicillin and streptomycin are the most commonly used to prevent bacterial infection or contamination in cell culture. However, the role of Penicillin-streptomycin in inducing mouse embryonic stem cells (mESCs) to differentiate into cardiomyocytes is unclear. To illustrate the mechanism of penicillin-streptomycin on inducing mESCs differentiation into cardiomyocytes, we firstly investigated mESCs differentiation into cardiomyocytes by the traditional method. e timespace expressions of cardiac-specific genes were detected by real-time PCR and western blotting at 8 different time-points over a period of 36 days.

HIV/AIDS occupy a special place among other diseases. It is Incurable and frightening disease, causing anger and denial.

Background: Blood is a specialized connective tissue with a complete and unchangeable identity. It provides one of the means of communication between cells of different parts of the body and the external environment. In modern medicine, blood transfusion is an important procedure to replace blood loss. At least 30 common antigens and hundreds of other rare antigens have been found in human blood cells and shown to be linked to anemia and other diseases.