• Journal of Biochemistry and Biophysics
  • Journal of Biochemistry and Biophysics
Scientific Research Highlights
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Identification and interrogation of combinatorial histone modifications

Histone proteins are dynamically modified to mediate a variety of cellular processes including gene transcription, DNA damage repair, and apoptosis. Regulation of these processes occurs through the recruitment of non-histone proteins to chromatin by specific combinations of histone post-translational modifications (PTMs).

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Closed loop adaptive optics for microscopy without a wavefront sensor

A three-dimensional wide-field image of a small fluorescent bead contains more than enough information to accurately calculate the wavefront in the microscope objective back pupil plane using the phase retrieval technique.

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Quantitative single-cell RNA-seq with unique molecular identifiers

Single-cell RNA sequencing (RNA-seq) is a powerful tool to reveal cellular heterogeneity, discover new cell types and characterize tumor microevolution. However, losses in cDNA synthesis and bias in cDNA amplification lead to severe quantitative errors.

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The Nonenzymatic Decomposition of Guanidines and Amidines

To establish the rates and mechanisms of decomposition of guanidine and amidine derivatives in aqueous solution and the rate enhancements produced by the corresponding enzymes, we examined their rates of reaction at elevated temperatures and used the Arrhenius equation to extrapolate the results to room temperature.

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Genomic mining of prokaryotic repressors for orthogonal logic gates

Genetic circuits perform computational operations based on interactions between freely diffusing molecules within a cell. When transcription factors are combined to build a circuit, unintended interactions can disrupt its function. Here, we apply \'part mining\' to build a library of 73 TetR-family repressors gleaned from prokaryotic genomes.



  • Journal of Biochemistry and Biophysics

    Journal of Biochemistry and Biophysics (JBB) is a peer reviewed open access journal providing a chance to researchers and scientists to explore the advanced and latest research developments within the field of Biochemistry and Biophysics. Journal of Biochemistry and Biophysics publishes the best quality scientific articles amalgamating broad vary of fields together with the fields associated with Biochemistry and Biophysics.

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