Recent Articles

Erosive hand Osteoarthritis (EOA) is a common and debilitating form of hand OA for which there are no proven or efficacious therapies. Interleukin-1 beta (IL-1β) plays a prominent role in OA joint inflammation. Canakinumab is a selective IL-1β inhibitor.

Excessive exposure to club drug gamma-hydroxybutyric acid (GHB) would cause cognitive dysfunction in which impaired Ca2+-mediated neuroplasticity in hippocampus may play an essential role in the pathogenesis of this deficiency. Considering melatonin is positive for neuroplastic regulation, the present study aims to determine whether melatonin would exert a neuro-protective effect on cognitive function following GHB.

13α(21)-Epoxyeurycomanone (EP) and eurycomanone (EN), the polar quassinoids of Eurycoma longifolia extract (TAF2) formulated as a lipid-based solid dispersion (TAF2-SD) to increase sperm count for oligospermic infertility, displayed improvement of oral pharmacokinetics and bioavailability in rats over the non-formulated TAF2 extract.

There are several anthropometric measures that are useful for diagnosis obesity and also are related to the development of different cardiovascular risk factors. The purpose of this study was to determine the predictive ability of various anthropometric parameters for the multiple risk factors aggregation (MRFA) in the adult population of the city of Maracaibo-Venezuela.

Obesity is a major public health concern in many countries. In Europe 4.1% of the girls and 5.4% of the boys aged 10-12 years are obese according to the International Obesity Task Force criteria.

Chronic anal fissure is a commonest anal condition of world population and our country is not an exception. Conservative management is initially recommended with creams and oral analgesics. When conservative measures fail despite of recommended length of therapy, surgical option is offered to the affecters.

Although plant derivatives have shown promise in reducing enteric methane (CH4) emissions from ruminants in short-term studies, investigation on possible rumen microbial adaptation to these compounds is still limited. The objective of this study was to assess the possibility of mixed rumen microbial adaptation to antimethanogenic plant derivatives over relatively long-term in vitro incubation. Treatments were: garlic oil, carvacrol and thymol, each at a final concentration of 300 mg/l.

Porphyromonas gingivalis is an anerobic, gram negative, bacterium which is a natural inhabitant of oral microbiome. Under unhealthy oral hygiene conditions the bacterium becomes highly destructive (photobiont) and leads to periodontitis (inflammation of periodontium).

Dysphagia is a common sequela post (chemo) radiotherapy ([C]RT) for head and neck cancer (HNC) and after stroke. The Shaker maneuver is a promising rehabilitative exercise for improvement of swallowing function by means of strengthening neck musculature.

During the Nigerian Civil War, the world community became aware of the deaths due to classical Kwashiorkor. However, the purpose of the present paper is to reveal that there was the hitherto unknown concomitant malnutrition disease due to paragonimiasis, this being due to eating poorly cooked crabs because of the stresses of war time.

Appendicectomy is one of the commonest emergency surgery performed across the globe. Long term complication post appendicectomy are rare. Chronic pain post operatively can be a debilitating problem, often without identifiable underlying cause.

A study of the history of the dermoid cyst of the ovary suggests that the old masters were only conversant with large tumors. The relatively smaller dermoid cyst with its typical greasy matter and hairs only came into recognition during the second half of the 19th century. Therefore, the purpose of this paper is to document how the medical masters of yester years became acquainted with this distinct disease.

In the United States (U.S.), the costs for health care and lost productivity due to diagnosed diabetes has increased from $174 billion in 2007 to $245 billion in 2012, making it one of the fastest growing public health burdens. Nearly 26 million adults have diabetes, and another 79 million have prediabetes, a condition that increases the risk for developing type 2 diabetes. Clearly to reduce the costs and improve health, preventing diabetes must be a priority.

Secretory villous adenoma is characterized with watery diarrhea, which may lead to dehydration, with resulting volume depletion, electrolyte imbalance, circulatory failure and renal dysfunction. We hereby report a case of villous adenoma associated with severe electrolyte imbalance complicated by diabetes insipidus.

An epidemiologic data pool was formed from cases of SCT submitted as surgical specimens to a Reference Pathology Laboratory serving the Igbo Ethnic Group in South-Eastern Nigeria.

Human islet amyloid polypeptide (hIAPP), a 37 residue peptide hormone is an ingenious factor in pancreatic amyloid deposits found in cases with type-2 diabetes. Its aggregation into small toxic oligomeric species is presumed to be the reason for cells debilitation and demise in case of diabetic patients.

Hair evidence is one of the most common types of evidence encountered in criminal investigations. The present preliminary study is aimed to investigate the racial discrimination through hair morphology viz. inner cuticle margin, cuticle thickness and medulla pattern among Malay, Chinese and Indian in Malaysia.

Increasing resistance to antimicrobial agents used in the treatment of infections based on Acinetobacter baumannii complex strains has become an important health issue.

Ceramic restorations are appealing because of their esthetics, high hardness and wear resistance. They can replace a composite or amalgam restoration in teeth where buccal and lingual walls remain intact and where excessive isthmus width contraindicates the use of a direct posterior composite restoration. Recent clinical trials have shown that porcelain restorations with margins on the occlusal surface of a posterior tooth tend to fail due to fracture of the porcelain under biting forces.

As a criminal defense attorney and criminology professor, I am amazed and excited that so many Americans have an interest in forensic science. When striking juries, I used to ask how many jurors watched television shows like CSI, Law and Order, and Forensic Files.