Recent Articles

Background: Exhaled Volatile Organic Compounds (E-VOCs) may help to early detection of colonic polyps Objective: Assess whether a new ambulatory device is able to detect specific E-VOCs in patients recently diagnosed with colonic polyps. Material and Methods: All data were collected during routine consultations for Small Intestinal Bowel Overgrowth. A breath test was performed by X-PID 9500®. Results: 203 patients older than 45 years of age were included. 31patients (15.3%) reported colonic polyps. 74 patients presented with gastroduodenal or jejunal (GDJ) liquid at ultrasound examination despite fasting. 96 patients (47.3%) exhaled numerous E-VOCs with a retention time between 12 to 45s (E-VOCs 12 to 45s). All patients of the polyp group exhaled E-VOCs 12 to 45s. 69 patients with GDJ liquid exhaled E-VOCS 12 to 45s. 11 patients out of these 69 cases (15.9%) present with polyps. 27 patients exhaled E-VOCs 12 to 45s and did not have GDJ, 20 of whom (74.1%) presented with polyps. When GDJ liquid is not objectivized after fasting, the sensitivity of the E-VOCs 12 to 45s to identify patients with colonic polyps is equal to 100.0% and the specificity is 93.6%. The positive predictive value is 74.1% and the negative predictive value is 100%. Conclusion: After fasting, X-PID 9500® is able to detect E-VOCs associated with colonic polyps, when GDJ liquid is excluded.

Low temperature (but above-freezing) during germination and early seedling growth of chilling-sensitive crop is one of the most significant limiting factors in the productivity. 2,4-Epibrassinolide (24-EB) is one of the most active forms of brassinosteroids are multifunctional plant hormones that can regulate development and respond to abiotic stresses. The effect of seed-pretreatment with 24-EB (12.5 μg/L) on photosynthetic characteristics, membrane permeability, lipid peroxidation and antioxidant activities under chilling stress were investigated in tomato (Lycopersicon esculentum Mill.) cultivars: Kulon (early ripening) and Yakhont (mid-early). Results showed that the use of 24-EB led to more pronounced changes in the pigment composition in Yakhont in the absence of a stress factor, whereas in Kulon under chilling stress (2 o C for 24 h). 24-EB pretreatment minimized the damage to cell membranes in tomato plants caused by chilling stress. The tolerance to chilling stress in Yakhont was higher than Kulon (by electrolyte leakage and content of malondialdehyde assay). Under these conditions, oxidative processes in plants of Yakhont did not show significant difference. We have not established the effect of 24-EB on the level of low molecular weight antioxidants in tomato cultivars (measured by inhibition of 2,2-diphenyl-1-picrylhydrazyl free radical method). The antioxidant activity of leaf extracts in Yakhont was twice as high as in Kulon under all experimental conditions (with/without 24-EB, 22/2 o C). It was concluded that the less pronounced reaction of plants of Yakhont to the use of 24-EB and chilling stress is due to their genetically determined higher cold resistance than that of Kulon.

We present rare case of medial meniscus dislocation, in a 25 years old female patient who was admitted in emergency department. With painful locked left knee. Arthroscopy was done next day showing isolated dislocation of medial meniscus with the absence of any medial meniscus tear. Only reduction of the medial meniscus was done. Postoprative MRI confirmed the diagnosis and showed no tears in the medial meniscus. Physiotherapy and clinical follow up were done with good results and no recurrence for 4 months postoperative.

Low levels of psychological wellbeing pose considerable burdens on society in terms of mortality, unemployment, absenteeism, medications, social services, morbidity, and in-out patients’ costs. Early detection and preventive treatments may help to reduce costs and improve quality of life. Researchers have proposed several measures and tried to identify new measures of psychological wellbeing, but there is not a universally accepted measure, and all the existing ones have their own limitations. This paper discusses research results focusing on behavioral, psychological, social, demographic features and biomarkers of psychological wellbeing and mental disorders associated with low psychological wellbeing levels. The features which are addressed in the paper are categorized into three groups: affecting features, features for therapy and detecting features. This categorization is described and defended.

In this paper, we take a creative look at the effect of cracking on the buckling of graphene sheets. We introduced a significant improvement in molecular mechanical calculations that more accurately examine the behavior of atomic bonds during the instability of nanostructures in the presence of defects. A molecular mechanics method based on the modified couple stress (MCS) theory to consider the size effect on the graphene plate is introduced. Primary cracks with different lengths, orientations, and numbers were examined. For each crack, buckling parameters such as critical load and buckling modes of graphene sheets were investigated. This model has better computational performance and less computational compactness than other models. Our studies show that cracks perpendicular to the load direction have a greater effect on buckling parameters, including modes and critical buckling load than cracks aligned to the critical load. Increasing the crack length will further reduce the critical buckling load. The effect of the number of cracks in two directions in buckling parameters was investigated. Increasing the number of cracks always decreases a critical buckling load. Increasing the number of cracks affects the first buckling mode more than others. The study of the eccentricity of cracks shows that with increasing the eccentricity distance, in cracks perpendicular to the loading direction, the critical buckling load will be further reduced. However, for cracks aligned with the load direction, increasing the eccentric distance has less effect on reducing the critical buckling load.

Ruthenium, Antimony and Vanadium doped and undoped tin oxide (SnO2) thin films were prepared by the R.F. Sputtering method. At the beginning of the thin film production studies, pellets were formed by pressing the filled and undoped tin oxide powders in the laboratory environment. The purpose of creating these pellets is to replace commercially purchased target material that acts as the coating material in the sputter coating device. The aim of the study is to use these pellets instead of this commercial target due to its disadvantages such as long lead time and expensiveness, and thus to produce easier, more diverse and high quality thin films. This study includes the synthesis of pure and doped thin films of tin oxide semiconductor material, which has a wide band gap and attracts attention with its wide spread use thanks to this feature, subjecting it to annealing process under different temperatures and times, and structural and morphological characterization studies: XRD, SEM, AFM, XPS, UV-Vis Spectrophotometer and Nano-hardness machine. The study showed that doped and undoped tin oxide films showed similar properties to similar studies seen in the literature, so that the pellets formed in the laboratory environment functioned. No major structural difference was observed in the films produced as a result of the use of pellets and target. As a result of the findings of the study, it has been seen that it is a preliminary study for the investigation of gas sensing properties.

Introduction: Studies from several countries have shown that there is a lack of knowledge related to child protection among dentists and their teams. So far, there are no data available about the situation in Germany. Aim of this study is to describe the perception of the role of German dentists in terms of child abuse and neglect. Material and Methods: A questionnaire previously used by other studies regarding the role of dentists in child protection was adapted to German terminology and provided online. The internet address has been shown in different German dentists’ association journals addressing dentists only. The participation was voluntary. Results: A total of 251 (79.68%) dentists completed the questionnaire with valid data, 62.5% reported to have had a sus- picion of child abuse or neglect. Of these, 21,7% had reported their suspicion to the social services. Dentists specialized in pediatric dentistry reported their suspicion more often. Most frequently reported barriers towards contacting social services were uncertainty about diagnosis, fear of violence towards the child and the lack of knowledge in terms of referral procedures. Most of the participants expressed a need for further education. Conclusion: Dentists in Germany are not able to fill their role in child protection matters sufficiently and show a need for undergraduate and continuing postgraduate training.

Due to the ever-increasing importance of studying pollution effects on environment and population, the development of methodologies for the evaluation of atmospheric pollutants has allowed great advances concerning air quality monitoring. Nitrogen dioxide (NO2) and fine particulate matters (PM2.5) have as major sources vehicle engine exhausts and industrial processes. In the municipality of Pelotas, the economical and industrial growth allied to the expansion of the local vehicle fleet have brought several impacts on human health and environment. For this region, there are few studies concerning air pollution monitoring and dispersion. Data were collected seasonally (summer, autumn, winter and spring) in eight points (Porto, Areal, Centro, Fragata, Simões Lopes, Três Vendas, Laranjal,and Capão do Leão) over the city area, aiming to have a picture of the city as a whole. Annual mean ± standard deviation of the PM2.5 measurements are: Porto 48.95±6.28, Areal 3.29±4.56, Centro 39.56±7.05, Fragata 30.28±3.59,Simões Lopes9.5±.9, Três Vendas 3.4±3.80, Laranjal 29.79±2.34, Capão do Leão 24.25±3.2 and annual mean ±standard deviation for NO2 were: Porto 9.06±.5, Areal 0.49±0.94, Centro 4.3±0.89, Fragata 2.44±0.56, Trem 7.20±0.99, Três Vendas 2.94±.22, Laranjal 8.83±.97, Capão do Leão 6.77±0.76. We conclude that there are significant differences in different places of the city, mainly due to traffic and human activities characteristics of each point. On the other hand, meteorological factors act similarly in all sites concerning the pollution dispersion.

Dysbiosis is microbial imbalance and mostly common in gastrointestinal tract [1]. There is a significant different of microbial communities in diarrheic cases more than healthy dogs’ comparison of gender & clinical signs. Clostridium species is mostly commonly genus found infectious animal cases of diarrhea and moreover in dog in other hand unclassified genus of Ruminococcaceae Bacteroidetes and Faecali bacterium were isolated. The microbiome functional gene content of (PICRUSt) with elevation gastric enzymes & increase titers infra structural proteins in acute diarrhea. Studies and data for dysbiosis with different intestinal disorders in dog associated with acute diarrhea or chronic is very limited. Current study to evaluate microbial dysbiosis. The fecal microbiome, characterized by 655 pyrosequencing of the different genes, AU/CG. There was lower range of bacterial isolates from cases of acute diarrhea compared to animal variation with statistical analysis. Altered microbial imbalance in gut occur with the microbial communities for gastric infection.

Background: Breast cancer is the most common cancer in women worldwide. Management of Breast cancer requires multidisciplinary team approach (viz, Surgery, Chemotherapy, Radiation therapy, Hormonal therapy & Targeted therapy). Radiotherapy reduces the risk of breast cancer mortality for women after breast conserving surgery and for women after mastectomy for node-positive disease. One of the organs at risk in breast cancer therapy is esophagus. As such, there is potential to expose greater volumes of esophagus to radiation. This may result in increased frequency and severity of acute radiation esophagitis during treatment. Aims and Objectives: To evaluate dosimetric parameters such as mean dose (Dmean) maximum dose (Dmax) which may influence the incidence and severity of esophagitis in breast cancer patients receiving radiotherapy. Material and Methods: Treatment plans of post mastectomy patients who had already received adjuvant RT of dose 50 Gy in 25 # over 5 weeks to the chest wall along with Supraclavicular field (SCF) using 3-Dimensional Conformal Radiation Therapy (3D CRT) and Intensity Modulated Radiation Therapy (IMRT) were selected. Mean dose (Dmean) and maximum dose (Dmax) to esophagus was assessed. Results: Dosimetric parameters assessed are Dmean and Dmax. Dmean assessed up to less than or equal to 11Gy and Dmax assessed upto less than or equal to 34Gy. The average of Dmean in this study is 8.34Gy which is within normal limits of prescribed dose. The mean Of Dmax in this study is 24.80Gy which is in limits of prescribed dose. Conclusion: Increased dose to esophagus in observed when IMRT is used especially when supraclavicular or internal mammary nodes are involved. Routine contouring of esophagus and planning accordingly may reduce oesophageal dose and acute oesophageal toxicity.

Background and Objective: In Cameroon, given the galloping growth in the prevalence of diabetes, in particular type 1 diabetes in the northern regions, we undertook this study, with the objective to improve the management of type 1 diabetes by determining the socio-demographic, clinical characteristics and lipid profiles of the patients followed in the care centers of regional hospitals of Maroua, Garoua and Ngaoundere. Methods: We undertook a descriptive cross-sectional study from 07 August 2018 to 07 May 2019 in the care centers of the regional hospitals. Sociodemographic and clinical data were collected by interview to consent patient through structured questionnaires in the survey sheet. Anthropometric data were also determined during the survey, and the blood was collected in referred laboratory for determination of some lipid profiles parameters. Results: On a sample of 467 Patient suffering from diabetes, 68 were of type 1, representing a prevalence of 26%. Type 1 diabetes Patients were mostly female (61.8%) and the mean age was 20.72 ± 3.4 years with a high percentage between 20-30 years (51.5%). More than half of our patients were pupils and students, many of them practiced Muslims as religion (58.8%). In most of cases (51.3%), the disease was diagnosed after one year as a result of illness. The majority of our patients were non-smokers (98.5%) and less athletic (32.4%). The mean Body Mass Index (BMI) was 23.03 ± 2.7 kg /m2 with an average waist circumference of 80.26 ± 9.23 cm in men and 82.15 ± 10.45 in women. Their treatment was based essentially on insulin therapy, mainly using regular and intermediate insulins. More than half of the subjects had high blood glucose (78.1%), high triglyceride (34.1%) and HDL-cholesterol (29.3%) levels. Most of the patients suffered from overweight/obesity, high blood pressure, arthritis, kidney failure and other diseases (malaria, jaundice, stomach ache). No significant relation was found between clinical and the sociodemographic and blood lipid profiles. Conclusion: It emerges from this study that type 1 diabetes represent high proportions of diabetes cases in septentrional area of Cameroon, and affect mostly young of less than 30 years old, dominated by women, practicing Muslim as religion. Their clinical profile characterized by high frequency of overweight/obesity, kidney failure and arthritis vary, but not significantly, with neither their sociodemographic nor their blood lipid profiles. Absence of sport, female and less control of their hypoglycemia are factors risks of the progression of the disease.

The use and the production of sanitizers have increased in the post-pandemic situation to prevent the further spread of COVID-19. Usability assessment of sanitizer containers is essentially required to evaluate the effectiveness, efficiency, and satisfactory use of the sanitizer containers. This study aimed to evaluate the system usability scale (SUS) as a marker of perceived usability of non-human computer interfaces, such as - sanitizer containers. The perceived usability of three types of sanitizer containers was evaluated using SUS. The authors have measured the reliability, convergent, and discriminant validity to evaluate SUS as a marker of usability of sanitizer containers. The result showed that SUS lacks convergent validity though it has a higher reliability coefficient. Thus, this is not the best measure of usability for non-human computer interfaces like-sanitizer containers. The SUS was applied on the flip cap, finger-pressure pump, and spray-type sanitizer containers. The finger-pressure pump container has exhibited a higher SUS score than others. The results of this study have given an idea about the usability of three different kinds of sanitizer containers. This research provides an overview of the application of SUS on non-Human computer interfaces like sanitizer containers. This study provides limitations like lack of convergent validity and ideas to overcome common method bias.

Introduction: Sickle cell disease (SCD) is a genetic hemoglobin disease for which there are many treatment options. Evidence supports the efficacy and cost-effectiveness of hydroxyurea (HU). Nevertheless, its use and adherence to treatment remain suboptimal, hence, the necessity to assess the factors influencing this observance. Objectives: The objective was to evaluate the factors influencing observance to HU in children with sickle cell disease from the Mother and Child Center of the Chantal Biya Foundation (MCC of the CBF). Materials and Methods: This was a descriptive and analytical cross-sectional study from January to June 2020. Children on HU for at least six months, and followed up at MCC of the CBF were included. Data collection was done using a pre-tested questionnaire. The level of compliance was assessed using the Morisky’s observance grid, where 8 points was considered as “good”; 6-7 points as “fair”, and

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Introduction: Mechanical disorganization of the bacterial biofilm is the cornerstone of the prevention of gingivitis and periodontitis periodontal diseases. The objective of this study was to evaluate the periodontal health of schoolchildren in Widou, Ferlo. Methodology: This was a descriptive, cross-sectional study of schoolchildren living in Widou in the centre of Ferlo. The survey was exhaustive and concerned the only school in the locality. The epidemiological data collected concerned oral hygiene practice, periodontal health and socio-demographic characteristics such as sex, age and educational level. The degree of hygiene was assessed by the Silness and Loe plaque index (Plaque Index); inflammation and bleeding on probing were assessed by the Loe and Silness gingival index (Gingival Index). Results: In a total of 126 schoolchildren, boys and girls were equally represented and the average age was 10 years +/- 2.16.Sixty-nine percent (69%) of the children examined did not use a toothbrush. Of these, more than 47% reported brushing 3 times a day. The plaque index mean value was 1.23 and 99.2% of the population had a moderate plaque control. The average gingival index was 0.96 and 80.2% of the sample had moderate gingival inflammation. Conclusion: The study showed a relatively low rate of toothbrush use in contrast to the tooth stick and a relatively high rate of periodontal index. Communication-based approaches to behaviour change in children are needed to improve periodontal health.

Among patients with tuberculosis (TB), approximately 1 to 5 percent develop central nervous system (CNS) complications. A tuberculoma is a conglomerate granulomatous focus that develops from coalescing tubercles acquired during disseminated bacillaemia. Radiographically, tuberculomas are discrete, ring- enhancing lesions of the brain surrounded by perilesional edema and may present as single or multiple lesions. The diagnosis of tuberculoma should be suspected in patients with mass lesion of the brain and relevant epidemiologic factors. A definitive diagnosis of tuberculoma is established via needle biopsy of the CNS lesion for histopathology and acid-fast bacilli (AFB) staining and culture. In this case report, we present a 43-year-old woman with a past medical history of rheumatoid arthritis (RA) managed with steroids and hydroxychloroquine, who attended to us with a two- month history of numbness and paresthesia of her left extremities and recurrent episodic jerks involving the same side. Brain magnetic resonance imaging (MRI) revealed a large hemorrhagic mass (55 * 40 mm) in right temporo-parietal lobe surrounded by edema and mass effect with small nodule in left peri Rolandic cortex. Following clinical and laboratory clues, MR spectroscopy and brain biopsy, we started with corticosteroids and the following 4 anti-TB drugs: Isoniazid, Rifampin, Pyrazinamide, Ethambutol (HRZE). After 2 months, her symptoms completely resolved and a subsequent MRI scan revealed considerable shrinkage of the right-sided mass and left-sided lesion.

A majority of Carbon-dioxide including smaller amounts of methane and nitrous are emitted from the consumption of fossil fuels around the world to meet the sustainable development goals and global prosperity. Studies have shown that the increase in greenhouse gases has negative effects on human health, and the environment around us. Emissions from the consumption of fossil fuels in factories and industries either to produce electricity or transport people, goods and services cause the release of CO2 and other pollutants into the atmosphere. The majority of industrial energy is supplied by nonrenewable energy resources, which mainly consist of fossil fuels. Currently, fossil fuels are the main source of energy and are concentrated in some regions of the world, therefore direct contamination occurs in areas where they are stored or processed. A majority of electricity consumed by cities and countries across the world is produced from fossil fuels, which accounts for the highest percentage of overall CO2 production in that particular country. People will share the common global environmental problems, either it is local or regional, hence immediate actions are needed to tackle problems at national and regional and global levels. Fortunately, with the advent of new technologies and intervention strategies, it is possible to reduce pollution and reduce the rate of rising global temperature that might result in better economy and ecological systems as well as providing sustainable energy resources. In this research the data on nonrenewable energy sources, fossil fuel reserves in different regions, production and consumption rate of fossils have been identified and reviewed. Additionally, mathematical calculation has been done to find the carbon dioxide emission amounts, both international and national legislations as well as further recommendations have been provided to reduce or prevent emissions.

With the purpose of valorizing the aromatic and medicinal plants, essentielly the Asteraceae family, and ethnopharmacological heritage in the area of Timahdite province of Ifrane, Morocco. An fieldwork has been carried and consists of conducting an ethnobotanical survey on Artemisia ifranensis J. Didier, endemic species, in the region of Timahdite, located in the Moroccan Middle Atlas. The Ethnobotanical study realised in June-July 2012 beside 82 different respondents permitted to describe their medicinal use at the local scale based on the local Known-how, and constitute a source of very precious information for the area studied and for subsequent researches for the domains of the phytochemistry and pharmacology in order to search for new natural substance. In tyhis study, the survey targeted men (70 %) and women (30 %), aged 30 to 50 years and The data Analysis showed that the overall level of schooling of the town was low (64% of the illiterate). The results of the study also had allowed to notice that the leaves was the usual used part (61 %). Most remedies are prepared in decoction (72%). Either, the survey revealed that the medicinal specie was mainly used against diseases of the digestive tract (63%), as well as for other treatment of various diseases as dermatological affection, and for relieving headaches or neuralgia. Moreover, it also comes out from it that the conservation and the sustainable management of the medicinal species identified should be ensured through a management plan.

Gangliocytic paraganglioma (GP) (nonchromaffin paraganglioma, paraganglioma) is a morphologically distinct tumor most commonly occurring in the second part of the duodenum in the proximity of ampulla of Vater. We herein, present a case report of appendiceal mass in a 16-year-old male who presented with recurrent right iliac fossa pain and steno sing cecal tumor on CT abdomen. He underwent right hemicolectomy and histopathological examination of appendix showed infiltration of appendiceal wall with gangliocytic paraganglioma. To our knowledge this is the first reported case of gangliocytic paraganglioma of appendix in our area.

Osteoarthritis is an inflammatory-degenerative joint disease that affects the osteochondral unit with the concomitant intervention of the immune system; this causes pain and progressive functional limitation. With a varied and complex etiopathogenesis, Osteoarthritis has a subtle outcome and an inexorable evolution towards joint deformity. The therapeutic approach makes use of non-pharmacological and pharmacological aids. Pharmacological therapy consists of symptomatic drugs that act on acute and especially chronic pain, in an attempt to decrease the incidence of any structural damage to the cartilage and subchondral bone. If the anti-resorptive drugs cure the subchondral-epiphyseal osteometabolic pathology, the interventions on the cartilage have not produced important and well evaluable results, even after prolonged therapies. This contribution analyzes the profile of Clodronate, used for the treatment of subchondral bone edema in Osteoarthritis, regarding its potential protective effects in cartilage, like DMOADs.