Recent Articles

The recent resurgence of interest in m6A has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6A modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity. The little information that has been established on its functional capacity has opened up many new avenues of research and has tremendous implications for several fields of study.

During the 19th Century, there was a difficult choice concerning whether a pancreatic cancer is primary or secondary. However, in this paper, it is shown that some views were decidedly in favor of attack from other primaries. Indeed, the evidence of spread to the pancreas included either concise or coalescent lesions.

Here we describe the case of a 35 year old male, with a harmonic phenotype, who sought medical assistance to assess the etiology of his infertility. As a result of clinical examination, karyotyping, FISH and molecular studies, we obtained the following karyotype: mos 45,X[18]/46,XY,idic(Y)q(11.2)[82]. Furthermore, the Y chromosome was characterized by the absence of the regions AZF2 (former AZFb, within the 11.22 band, and AZFc, within the 11.23 band), whereas the region AZF1 was conserved. Male infertility can be caused by several genetic alterations.

The first patient was a 77 year old man who had been on abiraterone for 12 months before his phosphorous was checked. At that point, it was 0.6 mg/dl, which is severely decreased. A full work up for hypophosphatemia showed normal parathyroid hormone and 25-hydroxyvitamin D. A urine study showed inappropriate excretion of phosphorous along with aminoaciduria and normoglycemic glucosuria.

Nanotechnology manipulates and creates matter to formulate nanometer scale materials and objects. It is an interdisciplinary field that involves a wide range of scientific and engineering disciplines, and has societal implications.

Coccidioidomycosis involving the larynx is a rare occurrence which seems to present with non-specific upper airway symptoms. The diagnosis is made by tissue biopsy and the treatment is usually fluconazole for 6-12 months depending on the clinical presentation. In unusual presentations of laryngeal problems clinicians should consider Coccidioidomycosis, especially in endemic regions.

A seventy five year male presented with acute onset right foot pain and swelling. Plain imaging revealed a lytic area in the medial and middle cuneiform bones of the right foot. Background history of resected pancreatic cancer and current presentation were consistent early diffuse disease recurrence of a pancreatic primary tumour. The presenting feature in this case was of symptomatic acrometastases, that is, metastases to the feet.

Complex Vescico-vaginal Fistulas (VVF) are a common cause of morbidity especially in elderly patients. These can be one of the most troublesome complications of obstetric trauma and pelvic surgery and usually occur due to previous operative interventions and/or as a result of chronic diseases. These are difficult to repair because of the poor or almost no supporting tissue left at the perineum as a result of the previous insults.

Appendicitis is a rare pregnancy associated surgical emergency, with appendectomy as the most frequent non obstetrical surgical procedure performed in pregnancy. Diagnostic delay increases maternal and fetal morbidity and mortality thereby highlighting the need for a prompt diagnosis and surgery. Two cases of appendicitis with pregnancy are being reported with abdominal pain as common presenting feature.

Large osteomas of the fronto-ethmoidal cavities are very rare benign tumors. Headache and ocular signs are the most common symptoms. Imaging allows the diagnosis. Treatment of ethmoid sinus osteoma is surgical. One case with orbital extension is reported and discussed. A 30 years-old male; complaining of swelling of themedial angle of the right eye. Computed tomography showed a right ethmoidal process with orbital extension. The tumor was removed through an external ethmoidectomy.

Infection with Salmonella spp can result in a variety of presentations such as enteric fever, septicemia, gastroenteritis, and septic arthritis. The common organisms seen in septic arthritis are Staphylococcus aureus and Streptococci which accounts for about 67% and 20% respectively. Salmonella spp however is less commonly seen in septic arthritis and it is usually associated with immunosuppression conditions and underlying chronic debilitating diseases such as malignancy, hemoglobinopathy, diabetes mellitus, and HIV.

A major part of nutrition research consists of the investigation of how food components affect the biochemical and physiologicalprocesses within the body. The rationale is that this mechanistic research will lead to a fuller understanding of disease etiology thereby generating information of practical value for the treatment and prevention of disease.

We report a case of a teenager with scoliosis and pectus excavatum who developed intraoperative refractory hypotension associated with prone position during posterior surgical correction of scoliosis. In this case, it was more difficult for the anesthetists to figure out the reason leading to severe hypotension when a surgery was partially completed, because there might be many confounding factors during surgery. Furthermore, TEE was difficult to be considered to be first diagnosis choice when patient have already underwent posterior spinal fusion surgery, compared to the cases previous reported that the surgery still did not begin.

There is a discrepancy in how phytoestrogens and soy products are viewed in science and medicine. Among edible plants, phytoestrogens are most abundant in soy, and are structurally and functionally analogous to estrogens, with their biological action mediated by estrogen receptors.

Cryopreservation is the use of ultra-low temperatures to preserve whole living cells and tissues in order to retain their structural integrity and maintain their physiological viability. It enables long term storage of cells in order to circumvent the need for continuous in vitro culture. When cryopreserving bovine embryos there are two means of cryopreservation: slow programmable freezing and vitrification. While controlled-rate and slow freezing can be applied widely to in vivo derived-embryos, this methodology remains less successful for embryos produced in vitro.

Mutation in a single nucleotide of a gene has the potential to change the structure and/or function of its protein. Albeit simply saying, it is not observed to be a general phenomenon. The effect of mutation is primarily determined by the stereochemical nature of the amino acid which has replaced the previous amino acid, resulting in the residue location being affected. Here we show that despite a change in the frequency of occurrence of a particular amino acid in a particular protein in different types of organisms, the overall function of the protein can still remain unaffected, even when the resultant protein conformation is relatively altered.

Accelerated aging and higher co-morbidity prevalence have increased non-antiretroviral (ARV) medications for HIV patients. We examined, over a 12 month period, non-ARV medication burden among HIV-positive patients 18-49 and ≥50 years using a comprehensive U.S. healthcare claims database in an age-and-gender matched analysis (1:3 matching ratio of cases to controls). Primary outcomes of interest included the median and mean number of unique non-ARV drug substances during the one month period with the highest number of prescriptions filled for each individual, and the mean number of unique classes of medication.

A standard laboratory procedure with cultures that grow exponentially involves regular dilution (so that the organism is never nutrient limited). When the logarithm of growth is plotted against time, exponential growth then appears as a series of parallel lines.

In the last years numerous methods have been developed and applied to reconstruct the structure and dynamic rules of gene-regulatory networks from different high-throughput data sources such as gene expression data.

The amyloid precursor protein (APP) is mainly known for being the precursor of the ß-amyloid peptide, which accumulates in plaques found in the brain of Alzheimer’s disease patients. Expression in different tissues and the degree of sequence identity among mammals indicate an essential and non-tissue specific physiological function.