Recent Articles

Although the discovery of the V617F mutation in the JAK2 gene has modified the understanding and treatment of polycythemia vera (PV), some patients display complex characteristics not recognized in the recent 2022 WHO classification. In the case reported here, no JAK2V617F nor JAK2 exon 12 mutations were identified

The steady population growth in Rajshahi City has led to an increase in construction activities to fulfill its growing infrastructural demand. The aim of this study is to assess the impacts of these urban construction activities on urban communities' physical and mental health in Rajshahi City. We applied a mixed-method approach to carry out this study. Data were collected through a semi-structured questionnaire from 150 respondents who are residing near ongoing major construction sites.

Penicillin and streptomycin are the most commonly used to prevent bacterial infection or contamination in cell culture. However, the role of Penicillin-streptomycin in inducing mouse embryonic stem cells (mESCs) to differentiate into cardiomyocytes is unclear. To illustrate the mechanism of penicillin-streptomycin on inducing mESCs differentiation into cardiomyocytes, we firstly investigated mESCs differentiation into cardiomyocytes by the traditional method. e timespace expressions of cardiac-specific genes were detected by real-time PCR and western blotting at 8 different time-points over a period of 36 days.

Objective: The aim of this project consists of the evaluation of the cell viability of adipose tissue (AT) harvested using the Superficial Enhanced Fluid Fat Injection (SEFFI) procedure standardized by the Authors (AG, FPB). The harvesting procedure was performed using two different cannulas having 0.8 mm and 1 mm side-port holes, respectively. Cells phe- notype and ability to adhere to the plastic surface have been analysed. 'Ihe results have been compared to those recorded in adipose tissue harvested using a liposuction system and processed with enzymatic digestion (collagenase).

Abstract Purpose: In this article, we review main clinical trials reported in the past decade. Methods: Stem cells are relatively undifferentiated, with unlimited proliferative ability; self-renewal capability and also they can differentiate into specialized cells. Somatic stem cells in adult organisms are responsible for regenerating and self-renewing tissue, Many different stem cell types reside in the eye. Results: One of the most important stem cells is limbal stem cell that retains in an undifferentiated state and exists in an optimal microenvironment or "niche". The importance of limbal stem cells in maintaining the corneal epithelium throughout life has long been recognized. Furthermore, stem cells in the retina have been for treatment of the retinal degeneration, which generally results in constant visual disturbance or even blindness. Conclusion: This review will briefly focus on the principal stem cells in the eye especially limbal stem cells.

Introduction: Buccal mucosal urethroplasty has revolutionized the surgical management of urethral strictures but the success of the procedure has been variable in different series. We have attempted to understand the interplay between buccal mucosal epithelial cells (BME) and the fibroblasts at the molecular level using connective tissue growth factor (CTGF) as a marker so that translation of this information would help in better urethroplasty outcomes.

In Brazil, the incidence of spinal cord injury (SCI) reaches 40 new cases/year/million. In other words, there are almost 6 to 8 thousand new cases per year, 80% of which are males, and 60% fall between the ages of 10 and 30.

Colorectal cancer (CRC) ranks as the third most common cancer and the second leading cause of cancer-related mortality globally, following lung cancer, in 2022 [1]. The etiology of CRC involves both environmental and hereditary factors, with environmental factors accounting for approximately 65% of CRC cases

Temporomandibular disorders (TMD) are a group of disorders that damage the temporomandibular joint (TMJ) and the muscles of mastication. They are commonly associated with parafunctional habits and clinical symptoms, such as headache, clicking, limitation of lateral movement, protrusion, and mouth opening, discomfort in the TMJ region, and vertigo

In recent years, gastrointestinal malignancies have ranked as the primary cause of cancer-related deaths across the globe. Despite remarkable progress in medical technology and treatment modalities, the majority of patients still experience local relapse and distant metastasis.It remains imperative to carry out in-depth investigations into the mechanisms underlying the occurrence and develpment of gastriointestinal tumours. Metabolic reprogramming

The objective of this study was to evaluate the bond strength of fiberglass posts cemented with Rely X U200 and Rely X Luting 2, with (A) and without (WA) ultrasonic activation in the root canal of bovine teeth. The penetration of the cements into dentine tubules was also assessed. Methods: Forty bovine incisors were selected and endodontically treated, and then divided into 4 groups (n = 10). Fiberglass posts were cemented with Rely X U200 and Rely X Luting 2 and activated with an ITSMO ultrasound insert in 2 groups; the other two groups received no ultrasonic activation. After 24 hours of cementation, the roots were sectioned into slices of approximately 1 mm each.

Gastric cancer (GC) continues to pose a significant global health challenge, particularly in advanced stages where treatment options are severely constrained. Immunotherapy represents a groundbreaking advancement in cancer treatment, exhibiting promising therapeutic effects in patients diagnosed with gastric cancer

Background: Oral cancer, a malignancy that manifests in the oral cavity, poses a significant health challenge globally. With its intricate interplay of genetic, environmental, and lifestyle factors, oral cancer has become a prevalent concern, demanding in-depth exploration and analysis

Globally, primary liver cancer ranks sixth in terms of morbidity among all cancer types, and it is the second most common tumor of the digestive tract. Furthermore, it is responsible for the fourth highest number of cancer-related deaths [1]. Among the various histological types of primary liver cancer, hepatocellular carcinoma (HCC) exhibits the highest incidence rate

This study aims to identify the risk factors for axillary lymph node metastasis (ALNM) and establish a novel nomogram for predicting the possibility of an ALNM model based on clinicopathological and characteristics of tumor location. A three-dimensional(3D) model was also established to accurately describe the location of tumors prone to axillary lymph node metastasis.

Hepatocellular carcinoma (HCC) is a common malignant tumor, and hepatitis B virus (HBV) is the main pathogenic factor. The occurrence of HBV-associated hepatocellular carcinoma (HBV-HCC) is a complex process caused by multi-gene and multi-step interactions. The synergistic effect of multiple cancer-promoting mechanisms accelerates the evolution of the disease from inflammation to tumorigenesis

Gastric cancer is a malignant tumor originating from gastric mucosal epithelium. And more than 90% of them are gastric adenomas. At present, surgical treatment is the main method to cure gastric cancer. We found that many genes may play a role in the occurrence and cell transformation of malignant in gastric cancer, including APOA2

Thyroid cancer (TC) is one of the most prevalent endocrine malignancies with an increasing incidence worldwide. Though therapeutic effect is relatively good in the vast majority of TC patients, the anaplastic thyroid cancer (ATC) remains one of the most malignant tumors. This study aimed to investigate the role of SETDB2, an epigenetic regulator, in the dedifferentiation of TC cells

Oral submucous fibrosis is a potentially invasive condition which leads to lockjaw and inability to eat. The pervasiveness rate oforal submucous fibrosis in India is 0.2-2.3% in males and 1.2-4.6% in females [II. Timely diagnosis and appropriate treatment is necessary to cease the advancement. A case oforal submucous fibrosis occurring in 38year old male patient is presented in this paper. The patient was advocated on the ill-effects of areca nut and chances of malignant transformation and treatment was given for the same.

Foreign body ingestion is a common occurrence among children and adultswith certain risk factorsincluding advanced age and psychiatric diseases. However, in clinical practice we encounter healthy adults who are diagnosed with unintentional foreign body ingestion and are suspicion would help clinicians for prompt diagnosis in such cases.