Recent Articles

There is growing evidence suggesting a correlation between multiple copies of transcription factor-3 (TCF3) and various malignancies, yet its impact on patients with breast cancer remains uncertain. The present study utilized the Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, and the UALCAN database to obtain expression profiles and clinical data from patients with breast cancer. A comparative analysis was performed to assess the differential expression levels of TCF3 in breast cancer tissues as compared to normal breast tissues. TCF3 was found to be overexpressed in breast cancer and exhibited significant associations with T stage, age, race, PAM50 subtype, histological type, ER, PR and menopause status. Subsequently, analyses were performed to determine functional enrichment. The enriched pathways encompassed xenobiotic metabolism by cytochrome P450, chemical carcinogenesis-DNA adducts, extracellular matrix organization, cornified envelope formation, collagen biosynthesis and modifying enzymes, as well as immunoregulatory interactions between lymphoid and non-lymphoid cells. Single-sample gene set enrichment analysis (GSEA) was utilized to evaluate the infiltration of immune cells. The methylation status of TCF3 was analyzed using the UALCAN and MethSurv databases. The overexpression of TCF3 is a significant contributor to decreased disease-specific survival (DSS) and progression-free interval (PFI). Likewise, the low methylation status of TCF3 is also associated with an adverse prognosis. Finally, the differential expression of TCF3 between tumor and normal tissues was validated using data from multiple sources, including GSE22820 dataset, 49 pairs of tumor and paracancerous samples sequencing data, and CPTAC dataset. Moreover, proteomic analysis of the CPTAC dataset showed that TCF3 expression was associated with alterations of multiple tumor-related pathways. Therefore, TCF3 may serve as a new tumor-related biomarker.

Puerperal infection is a public health threat which may lead to maternal death and poor neonatal outcomes. Chlorhexidine is a representative antiseptic that is effective against the bacteria colonized in the reproductive tract of women. But researcher’s attitude towards the antimicrobial effects of chlorhexidine on pregnant women are conflicting. We sought to evaluate the preventive effect of chlorhexidine on puerperal infection and neonatal outcomes.

Ovarian cancer is responsible from more than 150.000 death annually worldwide. This cancer is detected in the late stage, and is characterised with poor prognosis, therefore most cases result with death. The diagnosis and the treatment of the disease have to be improved for a better quality of life for patients. MicroRNAs are the noncoding RNAs in the length of 19-24 nucleotides which show suppressor effect on target genes. miRNAs are included in the pathology of various diseases including cancer. miRNAs being as the biomarker candidates in diagnosis, and their use in treatment as the inhibitors of the molecules mimicking the miRNA showed that they may be used as the new therapeutic target and agents. We detected with our group in our prior study conducted with disconcordant ovarian cancer twins that many miRNA molecules were different in ovarian cancer compared with the molecules in healthy sibling. The expression level of miR-142-3p that was selected from the miRNAs detected in the previous study was compared, and investigated in a wider ovarian cancer group, and in healthy control group. miR-142-3p expression level was investigated using the real-time PCR method in the present study involving 147 patients, and 100 healthy control group. The differences in the expression levels of miR-142-3p detected in the peripheral blood lymphocytes of ovarian cancer patients, and healthy control were statisticaly evaluated. The expression level of miR-142-3p was detected to have increased 3.11 fold in ovarian cancer patients compared with the levels in healthy controls, and the difference was statistically significant (p:0.00). These results suggest that miR-142-3p that was found significantly increased in the peripheral blood samples of ovarian cancer patients compared with the healthy controls might be used as a sensitive, noninvasive biomarker in the early diagnosis, and treatment and follow up of ovarian cancer.

Ovarian cancer is responsible from more than 150.000 death annually worldwide. This cancer is detected in the late stage, and is characterised with poor prognosis, therefore most cases result with death. The diagnosis and the treatment of the disease have to be improved for a better quality of life for patients. MicroRNAs are the noncoding RNAs in the length of 19-24 nucleotides which show suppressor effect on target genes. miRNAs are included in the pathology of various diseases including cancer. miRNAs being as the biomarker candidates in diagnosis, and their use in treatment as the inhibitors of the molecules mimicking the miRNA showed that they may be used as the new therapeutic target and agents. We detected with our group in our prior study conducted with disconcordant ovarian cancer twins that many miRNA molecules were different in ovarian cancer compared with the molecules in healthy sibling. The expression level of miR-142-3p that was selected from the miRNAs detected in the previous study was compared, and investigated in a wider ovarian cancer group, and in healthy control group. miR-142-3p expression level was investigated using the real-time PCR method in the present study involving 147 patients, and 100 healthy control group. The differences in the expression levels of miR-142-3p detected in the peripheral blood lymphocytes of ovarian cancer patients, and healthy control were statisticaly evaluated. The expression level of miR-142-3p was detected to have increased 3.11 fold in ovarian cancer patients compared with the levels in healthy controls, and the difference was statistically significant (p:0.00). These results suggest that miR-142-3p that was found significantly increased in the peripheral blood samples of ovarian cancer patients compared with the healthy controls might be used as a sensitive, noninvasive biomarker in the early diagnosis, and treatment and follow up of ovarian cancer.

Ovarian cancer is responsible from more than 150.000 death annually worldwide. This cancer is detected in the late stage, and is characterised with poor prognosis, therefore most cases result with death. The diagnosis and the treatment of the disease have to be improved for a better quality of life for patients. MicroRNAs are the noncoding RNAs in the length of 19-24 nucleotides which show suppressor effect on target genes. miRNAs are included in the pathology of various diseases including cancer. miRNAs being as the biomarker candidates in diagnosis, and their use in treatment as the inhibitors of the molecules mimicking the miRNA showed that they may be used as the new therapeutic target and agents. We detected with our group in our prior study conducted with disconcordant ovarian cancer twins that many miRNA molecules were different in ovarian cancer compared with the molecules in healthy sibling. The expression level of miR-142-3p that was selected from the miRNAs detected in the previous study was compared, and investigated in a wider ovarian cancer group, and in healthy control group. miR-142-3p expression level was investigated using the real-time PCR method in the present study involving 147 patients, and 100 healthy control group. The differences in the expression levels of miR-142-3p detected in the peripheral blood lymphocytes of ovarian cancer patients, and healthy control were statisticaly evaluated. The expression level of miR-142-3p was detected to have increased 3.11 fold in ovarian cancer patients compared with the levels in healthy controls, and the difference was statistically significant (p:0.00). These results suggest that miR-142-3p that was found significantly increased in the peripheral blood samples of ovarian cancer patients compared with the healthy controls might be used as a sensitive, noninvasive biomarker in the early diagnosis, and treatment and follow up of ovarian cancer.

Coronary stent fracture is a rare complication of stent implantation. The reported incidence of stent fracture among present drug-eluting stents from various studies ranges from 1% to 8%. Coronary stent dislodgement and embolization is also a rare complication in the current era of percutaneous coronary angioplasties

Tuboculosis is an infectious disease commonly in China especially in immunodeficiency patients. But multiple sites tuberculosis infection stays rare. We let's report A rare case: pulmonary tuberculosis with skeletal and lymphatic tuberculosis and successfully treated.

Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms, with pancreatic involvement being exceptionally uncommon. This case corresponds to a 67-year-old woman who consulted for pancreatic mass causing biliary obstruction and imaging studies suggested pancreatic adenocarcinoma or a neuroendocrine tumor. Histopathological analysis of a biopsy identified spindle-cell proliferation without atypia or necrosis and a characteristic

Background: Traditional neuron models rely on the all-or-none principle of action potentials, often overlooking the grad ed, energy-dependent dynamics that underlie real neural behavior. This limited view may contribute to our difficulty in un derstanding complex neurodegenerative disorders.

Guillian Barre Syndrome (GBS) is the most common cause of minor flaccid paralysis in the world and post-polio eradica tion is the most common cause on the Indian subcontinent as well. It affects 0.6-4 people per 1 lakh people per year. Guil lian-Barre syndrome should be distinguished by a variation associated with inflammation of the cortical area of brain of chronic inflammatory polyneuropathy predicting prognosis and clinical course. Children have a better prognosis than adults and usually recover after a different period. However, in the Pressing event of the disease, the damage can be severe and can lead to long-term residual disability which can hamper quality of life especially in young population.in such sce narios ,use of early rehabilitation may prove to be of good effect. This article gives an effective overview of the effect of the physical therapy in improving quality of life.:The objective of This article was to perform a summary of the currentKnowl edge-base on outcome and its determinants in using early rehabilitation programme as a part of GBS management.

ince the beginning of the industrial revolution, nanoparticles have been manufactured by many industries and incorporated into the development of various nanotechnologies. Our knowledge of the risks associated with them is limited, despite the fact that they are utilized in a wide variety of commercial applications.

Any illegal activity occurrence place is called as crime scene, in some context it also called as place of occurrence (PO), each and every crime scene is different like finger-print of every person, due to advancement in technology in every field in criminal investigation’s measure part, the documenting the crime scene also includes advancement using technology. A crime scene is any physical scene, anywhere, that may provide potential evidence to an investigator. It may include a person’s body, any type of building, vehicles, places in the open air or objects found at those locations.

Plant secondary metabolites, which are produced under stress, are vital in pharmaceuticals, food and flavor industries. Plant tissue culture technique enables the production of large quantities of metabolites in controlled environments using elicitors. In this study, silver nanoparticles (AgNPs) were applied to Kalanchoe blossfeldiana cultures in vitro for two weeks to determine their effect on secondary metabolite production. The results exposed that the AgNPs influenced biomass production considerably, with the highest responses at 0.5 and 1 mg L-1

The conventional drug discovery approach has a high failure rate, lengthy delays, and expensive prices. From target identification to clinical trials, advances in machine learning (ML) and artificial intelligence (AI) provide answers. Important machine learning techniques that support data processing and drug development include supervised, unsupervised, and reinforcement learning. Case studies demonstrate how AI has sped up the development of the COVID-19 vaccine

Nanocomposite hydrogels makes itself a crucial role in the field of pharmaceutical sciences along with other fields and it is one of the hybrid materials formed by combining both nanotechnology and material science. Various nanoparticles or nanostructures have installed into the hydrogel network to create these kinds of hydrogels, which aim to mitigate some of the benefits' disadvantages. Based on the composition of their nanoparticles

On-farm biosecurity measures prevent disease transmission between and within farms and, therefore can improve animal health outcomes and product quality, minimize production losses, and increase returns to smallholders, the majority of whom market milk informally. This study assessed associations of milk market outlets with on-farm biosecurity status and the resultant milk quality, production losses, and gross margins on a random sample of 140 farms stratified by milk market outlets (formal and informal)

The main objectives of this study were to characterize the morphological features of Barb and Arab-Barb horses, develop an assessment grid, and propose a breed standard for the Arab-Barb. A total of 20 measurements were conducted on 33 horses from the Tunisian National Haras at El Battan. Based on these 20 morphological measurements, four distinct body indices commonly used in horse breeding and evaluation were calculated

The use of cottonseed by-products are sources of protein, energy, and fiber, excellent nutrient feed alternatives for animals. However, cottonseed use is limited because of the presence of gossypol, as it causes serious problems to animal health. Thus, was evaluated ewe long-term supplemented of cottonseed during the pre-breeding season, breeding season, pregnancy, and lactation period (10 months). We used Santa Inês breed ewe with 43.2 ± 2.0 kg body weight (BW) and 3.0 ± 0.1 body condition score (BCS).

This experiment was conducted to determine the contents of total amino acids (TAAs) and standardized ileal digestible amino acids (SIDAAs) and chemical composition of canola meal (CM) samples, and to develop regression equations for predicting the TAAs and SIDAAs content of CM for broilers. Eight samples of CM were obtained from different origins

The use of unconventional ingredients in the formulation of monogastric feed is increasingly common and many studies have been conducted on the incorporation of agricultural by-products in rabbit diets