Recent Articles

Warfarin is the most frequently prescribed oral anticoagulant in the United States. Its indications range from treatment of deep venous thrombosis and pulmonary emboli to the prophylaxis and treatment of thromboembolic conditions associated with atrial fibrillation and cardiac valve replacement. While bleeding is the most commonly encountered complication warfarin induced skin necrosis (WISN) can be a rare complication. Extensive skin and deeper tissue necrosis may be encountered requiring multiple surgical debridement and reconstructive procedures along with the medical management.

In the post genomic era when several proteomes are on the verge of completion, promising field of protein based diagnostic techniques is emerging. Although protein detection have been used for a long time in clinical diagnostic test, yet high throughput proteomics approaches along with systems biology could be a step forward, towards the development of next generation diagnostic tools and pave a way for personalized medicine.

Decreases in muscle mass, strength and power are associated with ageing, all of which increase the risk of falls, and cause a loss of independence. Creatine supplementation is often used in younger athletes to improve anaerobic performance, power and strength, however the potential benefits of creatine supplementation in older individuals are less clear.

Violent offenders are individuals who are incarcerated due to any criminal charge for a violent offence against another individual-armed robbery, murder, attempted murder, kidnapping, assault which results in bodily harm and forcible confinement.

The current research in the field of drug delivery by which pulsatile release can be achieved has been intensified. The objective of the present study was to evaluate Luffa aegyptica mill powder as a novel superdisintegrant in the development of pulsatile drug delivery system (PDDS).

Cefpodoxime proxetil (CFPD PRXL) is broad spectrum, third generation cephalosporin; antibiotic. It is extremely bitter taste resulting in poor patient compliance. The aim of the present work was to prepare drug resin complex (DRC) using ion exchange resin (Kyron T-114) for taste masking and formulate oral reconstitutable suspension of DRC.

The study was conducted to investigate effect and the nutritive value of treated banana peel meal at substitutionary levels for maize and other ingredients on the feed efficiency, digestibility and cost effectiveness on broiler chickens diet. A total of one hundred and eighty (180) Arbor Acres broilers were randomly distributed into four treatment groups of 0%-control, 10, 20 and 30% inclusion of treated banana peel meal as T0, T10, T20 and T30 treatments respectively.

The development of effective drug delivery approaches for the treatment of AIDS and HIV infection is a global challenge. The advent of multidrug, highly active antiretroviral therapy (HAART), have increased the life span of HIV-infected patients.

Serial dilutions were performed with six disinfectants and two antiseptics to study the MIC-dilution (maximal dilution of disinfectant or antiseptic that inhibits each microorganism) and that dilution was contrasted with the antibiograms of each of the 159 bacteria recently isolated from ICU patients.

Cementifying fibroma is a rare benign fibro-osseous tumor belonging to the same category as fibrous dysplasia and cemento-ossifyingdysplasia. Clinically it usually presents as a painless, slowly growing mass in the jaw and thus the lesion is frequently ignored by thepatient until the growth produces a noticeable swelling and facial deformity.

A nasal septal abscess (NSA) is defined as a collection of pus between the cartilage or bony septum and the mucoperichondrium or mucoperiostium. It’s an uncommon disease that in the absence of early diagnosis and proper management may lead to lethal complications and cosmetic deformity.

Jugular foramen schwannomas arising from cranial nerves IX, X, and XI are uncommon pathological conditions, slowly growing benign tumors that constitute approximately 2.9 to 4% of all intracranial schwannomas. Jugular foramen schwannomas represent 10-30% of all tumors observed around the jugular foramen.

Three stage sampling technique adopted covering 1497 school age children from 24 villages of Jodhpur district and examined at household level for their nutritional anthropometry, dietary and nutritional deficiencies. Growth retardation was observed. Wasting was in 22.4 percent children significantly higher in boys. Stunting and underweight was 36.6 and 43.9 percent (Less than Median–2SD).

Shipment of liquid milk samples for bacteriological examination is a limitation to large scale epidemiological studies. Sampling bulk tank milk (BTM) with sample collection cards (WhatmanTM FTATMMiniCard) was identified as an interesting procedure to ease sample collection and shipment.

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of L-dihydroxyphenylalanine (L-DOPA), a precursor of dopamine, and is considered to be involved in many aspects of mental health. On the other hand, the epigenetic mechanisms have been recognized as mediators of stable changes in brain function.

EPCs (Endothelial progenitor cells) are the precursors of endothelial cells that form the inner lining of blood vessels and are involved in neovascularization and re-endothelializaton of injured tissues. These cells have the potential for treating a multitude of angiogenic disorders giving a new hope in the arena of vascular biology. In the present study, we have demonstrated that cord blood derived expanded CD34+ cells can be differentiated into functional EPCs in vitro.

Actinobacillus pleuropneumoniae causes porcine pleuropneumonia, a disease which occurs world-wide and affects pigs of all ages. The study on the protective immune mechanism is not thoroughly clear. An outer membrane protein (OMP) was identified by screening a phage library of 3~8kb random DNA fragments of A. pleuropneumonia serotype 7.

It is widely known that many problems in the mathematical biology can be modeled by the differential equations, and the corresponding systems are usually called as biological dynamic systems.

The high mortality associated with ovarian cancer is generally related to the development of drug-resistant disease. HMGA2 protein, a member of the high-mobility group AT-hook (HMGA) family of non-histone chromatin binding factors, is overexpressed in high-grade serous ovarian and tubal carcinomas, though little is known about its contribution to disease progression and drug resistance. We sought to assess whether compositional changes in HMGA2 production were associated with ovarian cancer progression.

Ovarian cancer constitutes the second most common gynecological cancer with a five-year survival rate of 40%. Among the various histotypes associated with hereditary ovarian cancer, high-grade serous epithelial ovarian carcinoma (HGSEOC) is the most predominant and women with inherited mutations in BRCA1 have a lifetime risk of 40-60%. HGSEOC is a challenge for clinical oncologists, due to late presentation of patient, diagnosis and high rate of relapse. Ovarian tumors have a wide range of clinical presentations including development of ascites as a result of deregulated endothelial function thereby causing increased vascular permeability of peritoneal vessels.