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Articles Related to Cancer

Exhaled Volatile Organic Compounds in Patients with a Medical History of Cancer/Dysplasia

Exhaled Volatile Organic Compounds (E-VOCs) have been associated with cancer and may help to early detection or even identify pre-cancerous status.
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Application of the Posterior Approach Technique in Laparoscopic Radical Hysterectomy for Cervical Cancer

The aim of this study was to compare and determine the feasibility, surgical outcomes, intraoperative and postoperative complications of the use of the posterior approach technique in the laparoscopic radical hysterectomy (LRH) to the conventional laparoscopic radical hysterectomy in patients with cervical cancer.
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Cranial Vault Tumor Revealing Metastatic Thyroid Carcinoma

Distant metastases from follicular thyroid carcinoma are not uncommon, but bone localization in the cranial vault is extremely rare. Although these metastases have a poor prognosis, early diagnosis and appropriate treatment can improve quality of life. We report a case of follicular thyroid carcinoma revealed by a metastasis of the cranial vault initially diagnosed as meningioma.
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Oral Carcinoma in Young-Clinico-Pathological Profile and Survival Outcomes in a North Indian Population

To study the prevalence, clinico-pathological profile and survival outcome of oral squamous cell carcinoma in young patients (<40 years).
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Multiple Sclerosis Disease Modifying Therapy and Cancer risks

Multiple sclerosis (MS) is a chronic inflammatory condition not commonly associated with cancer. Although since 1993 with the introduction of disease modifying therapies (DMTs), changing the natural history of the disease, cancer risk appears associated with some of these new therapies. We present the most common risks associated with each DMTs.
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Drug Therapy Problems and Clinical Outcomes Among Patients with Human Epidermal Growth Factor Receptor 2 (HER2) Positive Breast Cancer on Trastuzumab-Based Therapy in a Kenyan Tertiary Health Facility

Breast cancer ranks first among the most commonly diagnosed cancers in Kenyan females and globally. Treatment is challenging because it is a heterogeneous disease with several subtypes. There has been a significant change in the treatment of Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer subtypes following the introduction and widespread use of HER2 targeted therapies.
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Clinicopathological and Prognostic Value of Plasmacytoid subtype in Bladder Cancer: A Systematic Review and Meta-Analysis

The World Health Organization, in 2004, published a new classification that recognizes different histological variants (HV) of urothelial carcinomas
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A Screening Study of Cervical Cancer Using Pap Smear Test in Outpatient Clinic of Must University Hospital

Despite the well-established importance of early cervical cancer detection, there are no clear data about the prevalence of cervical intraepithelial lesions among Egyptian population due to lack of screening programs. Thus, we conducted this study in order to assess the prevalence of inflammatory, premalignant and malignant cervical lesions among Egyptian population using Pap smear test.
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Cost-Effectiveness and Budget Impact Analysis of Recombinant Tumor Necrosis Factor-Thymosin Alpha 1 in a Complex Treatment of Metastatic Breast Cancer

Recombinant tumor necrosis factor -thymosin alpha 1 (TNF-T) has been used in Russian oncological practice for a number of years.
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Predictive Value of ERCC1 Expression on Treatment Response to Cisplatin-Based Regimens in Small Cell Lung Cancer: A Retrospective Analysis

We aimed to determine whether the excision repair cross-complementation group 1 (ERCC1) expression predicts response to cisplatin-based chemotherapy in patients with small cell lung cancer (SCLC). This was a retrospective study, in which hospital files of 31 patients (29 males, 2 females; mean age, 62.26±7.71 years) were reviewed. All patients were treated with etoposide+cisplatin. The lung biopsy and mediastinal lymph node samples were applied anti-human monoclonal antibodies against ERCC1: immunohistochemical staining was considered positive if 25-100% of the cells showed nuclear staining, and negative if less than 25% of the cells showed negative or slight staining. Response to treatment was evaluated as regression (complete or partial response), progressive disease, or stable disease. Of the patients, 18 (58.1%) had limited-stage, and 13 (41.9%) had extensive-stage SCLC. Median follow-up duration was 15 months (range: 1-60 months). ERCC1 staining was positive in 9 of 31 patients (29.0%). In 12 patients (38.7%), tumor regression (complete or partial response) was obtained after chemotherapy. Tumor regression rate was higher in ERCC1 positive patients than those with negative ERCC1 expression (66.7% vs. 27.3%, p=0.036). In conclusion, high expression of ERCC1 was associated with higher response rate to cisplatin-based regimens in patients with SCLC.
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Monoclonal Antibodies for the CIGB-552 Antitumor Synthetic Peptide Quantification

The CIGB-552 peptide is a synthetic peptide that exerts cytotoxic effect on tumor cells. Thus, CIGB-552 peptide quantification in patient samples is crucial for assessing the treatment efficacy. Therefore, this study describes the generation and characterization of monoclonal antibodies (mAb) directed against the CIGB-552 peptide to be used in a quantification assay in further pharmacokinetic studies in humans. In this sense, the CIGB.552-H294 mAb specificity was evidenced only against the CIGB-552 peptide and a metabolite of 17 amino acids resulting from the CIGB-552 peptide degradation detected in mouse sera.
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Profile of Tumor-Associated Cytokines among Breast Cancer Patients: A Preliminary Study

The link between disease and the oral cavity represent clinically important factors that have given rise to the interest in using saliva as a diagnostic fluid for systemic diseases. The objective of this study was to detect and quantify cancer related cytokines in the saliva of women with breast cancer and compare their concentrations to a healthy cohort.
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microRNA 181a-5p Reprogramed Glucose and Lipid Metabolism in Non- Small Cell Lung Cancer

microRNAs play critical roles in cancer metabolisms. miRNA-181a-5p is significantly down-regulated in non-small lung cancer tissue and mesenchymal like lung cancer cells. Epithelial-mesenchymal transition mechanisms and cancer metabolism are controlled by the same signaling pathway.
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Commitment to the Quality of Global Life and Emotional Function of Women with Cancer in Chemotherapy

To evaluate the quality of life and the impairment of the emotional function of women with breast cancer under chemotherapeutic treatment, in relation to sociodemographic and clinical characteristics. Observational, longitudinal, and analytical research; conducted between 2013 to 2015 with 67 women in three stages of chemotherapy treatment in a public referral teaching hospital in Paraná. Two questionnaires, one for socio-demographic and clinical data, and the Quality of Life Questionnaire-C30 were used for data collection.
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The Contribution of Alcohol Consumption to Overall Cancer Incidence in the Western World: A Meta-Analysis

The effect of alcohol consumption on overall cancer incidence is not clear. The aim of the paper is to estimate the impact of alcohol consumption on risk distribution of the 20 most common cancer types among men and women in the Western world. A meta-analysis of relative risks for the 20 most common cancer types potentially associated with alcohol consumption in the Western world was conducted based on the most recent cancer specific meta-analyses. Cancer risks were compared between men and women applying a sigmoidal dose response model. Drinking 2.5-14.9 g alcohol/day was associated with a small decrease in overall cancer incidence: 0.977 for men and 0.974 for women; followed by a small increase in the 15-29.9 g/day category: 1.029 for men and 1.077 for women. Further increases were observed in the 30-60 g/day category indicating a 5 and 10% increase in overall cancer risk for men and women, respectively. Women appeared to be more sensitive: the alcohol consumption level to acquire overall risk increase is 22 g/day for women and 46 g/day for men.
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Editorial Board Members Related to Cancer

Nejat Dalay

Professor
Istanbul University Oncology Institute
Turkey

Parameswaran Ramakrishnan

Assistant Professor
Experimental Pathology
Case Western Reserve University
United States

Ki Baik Hahm

Professor
Cancer Prevention Research Center
CHA University
Korea

Jason X. Cheng

Assistant Professor
Department of Pathology, Hematopathology
University of Chicago
United states

ALI AMIN

Assistant Professor
Warren Alpert Medical School
Brown University
United States

Doug Fairlie

Division of Structural Biology
The Walter and Eliza Hall Institute of Medical Research
Australia

Ann Gaba

Assistant Professor
City University of New York
United States

AMER K. KARAM

Associate Clinical Professor
Department of Obstetrics and Gynecology
Stanford University Hospital and Clinics Stanford
United States

ARA ANTONYAN

Associate Professor
Department of Biophysics
Yerevan State University
Armenia

Jiang He

Associate Professor
Department of Radiology and Medical Imaging
University of Virginia
United States
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