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Articles Related to Cancer

Therapy-related Myeloid Neoplasms after Pediatric Solid Cancer in a Single Reference Cancer Center in Brazil

Pediatric cancer overall survival has increased due to improvements in treatment. However, long-term adverse effects are a challenge for this population. Secondary myeloid neoplasm (MN) is one of the complications of solid tumor treatment. Therapy-related myeloid neoplasms (t-MN), therapy-related acute myeloid leukemia (t-AML), and therapy-related myelodysplastic syndrome (t-MDS) are the most common events. The aim of this study was to report a large pediatric sample and the relevance of t-MN after pediatric solid tumor therapy. We conducted a retrospective study between 2000-2016 in a cohort of pediatric patients treated for solid tumors who developed a secondary MN by medical records review and analysis. Seven from 2178 pediatric patients who were previously treated for solid tumors, were diagnosed with t-MN in a reference cancer center in Brazil. The median age at primary tumor diagnosis was 12.8 years old. Osteosarcoma, atypical primitive neuroectodermal tumor (PNET), Ewing sarcoma, and retinoblastoma were the most frequent solid tumors associated with t-MN. Three patients had a story of familiar cancer, and one patient with osteosarcoma had Li-Fraumeni syndrome confirmed. The median latency period to secondary MN was ten months and the prevalence rate was 0.32%. Two patients developed t-MDS and five, t-AML. All these patients received cytotoxic agents’ high doses that may have been associated with t-MN development. t-MN initial control, as well as unfavorable cytogenetic abnormalities, may have contributed to the poor outcome. We described the rarity of t-MN related to previous solid tumor therapy in a large pediatric sample in a Brazilian Cancer Center and their poor prognosis.
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A Java Software for Randomized Phase II Clinical Cancer Trial Designs

Traditionally, a typical phase II trial has been conducted using a single-arm design recruiting patients only to the experimental therapy to be compared with a historical control. Due to a small sample size and heterogeneity of patient population, the patient characteristics of the patients in a new phase II trial is often different from that of the selected historical control, so that the single-arm phase II trial may lead to biased conclusions. A randomized phase II trial can resolve such problems by randomizing patients between an experimental arm and a control arm. We propose a software package for designing and analyzing randomized phase II trials. We develop a user-friendly Java software that will help us find optimal two-stage phase II trial designs. Although the programs accommodate trial designs based on various statistical methods and different types of early stopping rules, the main part of our paper is focused on randomized phase II trials based on Fisher’s exact test with futility and superiority early stopping values. If users enter input parameter values, the software generates a graphical output displaying all efficient two-stage designs. Minimax, optimal, and admissible designs are highlighted as good designs, but users can select any of the displayed designs. When the circle representing a design is clicked, all the specifics of the selected design are displayed. Fisher’s test is an exact method whose critical values depend on the total number of responders from two arms. So, the computations required to search for optimal randomized multi-stage phase II trial designs based on Fisher’s exact test is very heavy. By using efficient algorithms, our software provides output at almost real time speed
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Solitary Adrenal Metastasis: A Case Report of Aberrant Behavior of Prostate Cancer

A Caucasian male with prostate cancer under androgen deprivation therapy after radiotherapy for a locally advanced lesion. Positron emission tomography/Computed Tomography revealed an adrenal lesion. The mass was removed, and histopathological examination showed adenocarcinoma of prostatic origin. Prostate-specific antigen decreased dramatically after adrenalectomy
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Correlation between Overall Survival and Quality of Life in Patients with Esophageal Cancer: A Comparison between Radiation and Chemoradiation

Desirable treatment options for inoperable esophageal cancer considering not only overall survival (OS) but also quality of life (QOL) during the entire clinical course remain unclear. We evaluated OS and QOL during the clinical course of patients with inoperable esophageal cancer undergoing chemoradiation or radiation. Forty-four patients with inoperable esophageal cancer between 2015 and 2020 were included in this retrospective study.
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Late Benign Gastrobronchial Fistula after Esophagectomy for Esophageal Cancer: A Case Report

Benign gastrobronchial fistula (GBF) is extremely rare but highly fatal complication of esophagectomy for upper gastrointestinal system cancers. We present a benign GBF after three years esophagectomy for esophageal cancer with presenting recurrent pneumonia. We choose wedge bronchoplasty without lobectomy and primary repair of gastric conduit as an approach.
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Impact of the Prognostic Nutritional Index on Quality of Life of Terminal Cancer Patients

When cancer is terminal and cancer-directed therapy has no value, the goal of treatment is to improve the quality of life (QoL). The current work proposed to assess the prognostic nutritional index (PNI) on QoL in patients with terminal cancer
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How Nurse Education Impacts Her Career?

A great proportion of healthcare services need high-quality medication and nursery. For high-quality nursery needs best nurses and their education. Gradually, different types of nursery education systems can impact their life and career. In the future, more parameters can be used for judging the quality and promotion of nurses. This editorial addresses different educational efforts for their progresses in medical knowledge promotion, technical capability improvement and salary promotion.
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Sysmex UD-10 should Accompany UF-5000 in Managing Atypical Cells in Urine

Sysmex UF-4000/5000 uses fluorescence flow cytometry technology and hydrodynamic focusing for urine sediment analysis, where particles are stained by specific fluorochromes for nucleic acids and surface structures and then sent through the semi-conductor laser beam. Atypical cells show side fluorescence and scattered light properties indicating their enlarged nuclei and increased nucleus/ cytoplasm ratio
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Exhaled Volatile Organic Compounds in Patients with a Medical History of Cancer/Dysplasia

Exhaled Volatile Organic Compounds (E-VOCs) have been associated with cancer and may help to early detection or even identify pre-cancerous status.
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Application of the Posterior Approach Technique in Laparoscopic Radical Hysterectomy for Cervical Cancer

The aim of this study was to compare and determine the feasibility, surgical outcomes, intraoperative and postoperative complications of the use of the posterior approach technique in the laparoscopic radical hysterectomy (LRH) to the conventional laparoscopic radical hysterectomy in patients with cervical cancer.
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Cranial Vault Tumor Revealing Metastatic Thyroid Carcinoma

Distant metastases from follicular thyroid carcinoma are not uncommon, but bone localization in the cranial vault is extremely rare. Although these metastases have a poor prognosis, early diagnosis and appropriate treatment can improve quality of life. We report a case of follicular thyroid carcinoma revealed by a metastasis of the cranial vault initially diagnosed as meningioma.
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Oral Carcinoma in Young-Clinico-Pathological Profile and Survival Outcomes in a North Indian Population

To study the prevalence, clinico-pathological profile and survival outcome of oral squamous cell carcinoma in young patients (<40 years).
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Multiple Sclerosis Disease Modifying Therapy and Cancer risks

Multiple sclerosis (MS) is a chronic inflammatory condition not commonly associated with cancer. Although since 1993 with the introduction of disease modifying therapies (DMTs), changing the natural history of the disease, cancer risk appears associated with some of these new therapies. We present the most common risks associated with each DMTs.
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Drug Therapy Problems and Clinical Outcomes Among Patients with Human Epidermal Growth Factor Receptor 2 (HER2) Positive Breast Cancer on Trastuzumab-Based Therapy in a Kenyan Tertiary Health Facility

Breast cancer ranks first among the most commonly diagnosed cancers in Kenyan females and globally. Treatment is challenging because it is a heterogeneous disease with several subtypes. There has been a significant change in the treatment of Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer subtypes following the introduction and widespread use of HER2 targeted therapies.
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Clinicopathological and Prognostic Value of Plasmacytoid subtype in Bladder Cancer: A Systematic Review and Meta-Analysis

The World Health Organization, in 2004, published a new classification that recognizes different histological variants (HV) of urothelial carcinomas
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Editorial Board Members Related to Cancer

Arif Gulzar

Department of Material Science and Chemical Engineering
Harbin Engineering University
China

Khaldon Bodoor

Associate Professor
Department of Biotechnology and Genetic Engineering
Jordan University of Science and Technology
Jordan

SONAL GUPTA

Assistant Professor
Department of Pathology
University of Texas MD Anderson Cancer Center
United States

Xiaoming Yang

Professor
Department of Radiology
University of Washington School of Medicine
United States

AMIR A. BAJOGHLI

Clinical Associate Professor
Department of Dermatology
Virginia Commonwealth University Inova Medical Campus
United States

Ray Kirk

Associate Professor
School of Health Sciences
University of Canterbury
New Zealand

Huafeng Zhang

Professor
School of Life Science
University of Science & Technology of China
China

MICHAEL H. A. ROEHRL

Associate Professor
Department of Laboratory Medicine and Pathobiology
University of Toronto
Canada

Ming Tan

Associate Professor
Mitchell Cancer Institute
United States

JANAK PADIA

Associate Professor
Center of Biomolecular Therapeutics
University of Maryland
United States
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