Articles Related to DNA methylation
DNA Methylation Status of the Methylenetetrahydrofolate Reductase Gene is associated with Depressive Symptoms in Japanese Workers: A Cross-Sectional Study
Polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene, that is considered to be the most important genetic determinant of blood homocysteine concentration, are associated with various diseases, including psychiatric disorders. However, the epigenetic factors influencing on the transcription and expression of this gene are unclear.
Epigenetic Changes Caused by Occupational Stress in Humans Revealed through Noninvasive Assessment of DNA Methylation of the Tyrosine Hydroxylase Gene
Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of L-dihydroxyphenylalanine (L-DOPA), a precursor of dopamine, and is considered to be involved in many aspects of mental health. On the other hand, the epigenetic mechanisms have been recognized as mediators of stable changes in brain function.
The recent resurgence of interest in m6A has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6A modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity. The little information that has been established on its functional capacity has opened up many new avenues of research and has tremendous implications for several fields of study.