Articles Related to Evans Syndrome
Novel Alternative Treatment to Plasmapheresis in Evans Syndrome
Evans syndrome is a rare haematological disease characterised by concurrent occurrence of autoimmune haemolytic anaemia
(AIHA) and idiopathic thrombocytopenic purpura. The autoimmune haemolysis can lead to hyperbilirubinaemia, profound anaemia
and haemodynamic instability. It can be difficult to treat and when refractory to medical treatment it could necessitate emergency
splenectomy. Plasmapheresis is used in refractory haemolytic anaemia to aid removal of disease causing autoimmune complexes whilst
immunomodulators act to reduce autoantibody response and effectiveness. However, this is an expensive and resource intensive process
that is limited to tertiary referral centres. In this case study we present a successful novel alternative for life threatening AIHA in Evans
Syndrome using haemofiltration with on-going fresh frozen plasma transfusion when resources are limited or it is not an accessible
method.