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Methadone and Torsade De Pointes in the Therapeutic Range

Methadone, a long-acting opioid agonist, binds to and occupies mu-opioid receptors, preventing withdrawal symptoms for 24 hours or longer, reduces craving for opioids, and, by maintaining high levels of opioid tolerance, reduces the euphoric effects of subsequent illicit opioid use. As a controlled substance with potential for abuse, methadone use is regulated in the US and other countries.
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The Infanticide: Some Forensic and Ethical Issues

Forensic investigation and clinical treatment of infanticide mother is an occasion to reflect about the social stigma associated with this crime. The forensic-psychiatric assessment must be anchored on an authentic and meaningful clinical relationship to criminal mother, without misinterpretation and countertransferal dynamics, such as emotional reactions of mistrust and stigmatization of the offender.
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