Articles Related to Renal transplant

The choice of induction immunosuppression can affect several outcomes after kidney transplant (KTx). We aimed to evaluate infectious and malignant complications between alemtuzumab and basiliximab in elderly KTx recipients. Patients ≥ 65 years old who received alemtuzumab or basiliximab induction for their primary KTx from 2006 – 2018 were included.

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Cryptococcosis caused by Cryptococcus gattii differs from that due to C. neoformans by an increased incidence of cryptococcomas in lung and brain, higher neurological morbidity and slower response to antifungal therapy. A case report of a renal transplant recipient with disseminated and fatal cryptoccocosis is presented. For this patient and for 12 controls, bronchoalveolar lavage fluid levels of IL-10, TNF-α, IL-12p40, CXCL-8 and CXCL-10 were measured. Broth microdilution assay, in accordance with CLSI-M27-A3 document was performed to determine antifungal susceptibility. BAL yielded yeasts when cultured that were identified as C. deuterogattii through biochemical reactions and URA5-RFLP genotype. The strain presented susceptibility to amphotericin B, itraconazole, voriconazole, fluconazole, and ketoconazole. The patient presented significant higher levels of IL-10 (73.22 pg/mL), IFN-γ (257.08 pg/mL), CXCL-8 (161.93 pg/ml) and CXCL-10 (1000.76 pg/mL) than controls. Different from C neoformans, scarce data are available about the immune response in patients with C. deuterogattii infection, especially cytokine profile on BAL.

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Tuberculosis is common infectious complication in kidney transplant recipients. In immunosuppressed patients, clinical manifestations of tuberculosis are varied and delayed diagnosis and poor clinical outcomes. Especially allograft involvement of tuberculosis can cause allograft loss. In this report, we present the case of 46-year-old man diagnosed disseminated tuberculosis involving allograft kidney successfully treated with maintenance of allograft function.

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Mycobacterium chlorophenolicum is a nontuberculous mycobacterium that has previously been characterized as nonpathogenic. We describe a 44 year-old patient with a history of deceased donor renal transplant on sirolimus who was found to meet criteria for both sirolimus-associated pneumonitis and secondary infection with Mycobacterium chlorophenolicum.

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Mycophenolic Acid (MPA) is one of the most widely used immunosuppressive agents in kidney transplantation. This study was designed to compare the safety, tolerability and efficacy of two formulations of mycophenolic acid, Mycophenolate Mofetil (MMF) and Enteric-Coated Mycophenolate Sodium (EC-MPS), in renal transplant recipients.

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