Articles Related to Severity
The Roles of IL-33 and TGF-Β1 in the Pathogenesis of Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis: Potential Biomarkers for Disease Severity
MicroscopyStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a disease continuum of potentially life threatening, severe allergic drug reactions which result in cellular apoptosis in the skin, mucous membranes, and ocular surface. The exact pathophysiologic mechanisms leading to this apoptosis is unclear but genetic predisposition and abnormal immune regulations play a role.
Neurobiochemical Roles of Low Molecular Weight Antioxidants on Oxidative Stress Biomarkers and Severity of Ischemic Stroke in Wistar Rats
Purpose: To evaluate the neurobiochemical role(s) of low molecular weight (LMWA) antioxidants in the treatment of surgically- induced ischemic stroke (IS) in wistar rats.Methods: Ischemic stroke was induced in wistar rats using middle cerebral artery occlusion (MCAO). Neurological assessments were carried out using stair case, cylinder test and modified neurological severity score (mnss) methods. Low molecular weight antioxidants (vitamins C, E, α-lipoic acid, dimethyl sulfoxide and mannitol) were orally administered to the rats for two weeks in three different doses (22.5, 45 and 67.5 mg/kg).
Relationship of YWHAH Single Nucleotide Polymorphisms to Markers of Rheumatoid Arthritis Disease Severity
Introduction: Serum 14-3-3 eta provides diagnostic and prognostic information in Rheumatoid Arthritis (RA). It is coded by the YWHAH gene with single nucleotide polymorphisms (SNPs) linked to bipolar disorder and schizophrenia. It was hypothesized that 6 previously described YWHAH SNPs might relate to markers of RA disease severity such as seropositivity or erosive changes. Association study performed at an academic hospital Rheumatology Clinic. Subjects studied were 18 years of age or older with RA. TaqMan analysis screened for YWHAH SNPs rs2246704, rs2853884, rs3747158, rs4820059, rs7291050, rs933226. Primary endpoint was presence of at least one copy of the YWHAH SNPs with the markers of RA disease severity.
The Association of Grades of Photoreceptor Inner Segment-Ellipsoid Band Disruption with Severity of Retinopathy in Type 2 Diabetes Mellitus
A prospective case-control study was undertaken to evaluate the association of inner segment-ellipsoid (ISel) band disruption with severity of diabetic retinopathy on spectral-domain optical coherence tomography. ISel disruption was graded as - grade 0: intact ISel; grade 1: focal disruption (subfoveal ISel disruption) and grade 2: global disruption (ISel disruption involving macular cube). Increased severity of diabetic retinopathy was found to be associated with increase in disruption of ISel (r = 0.49, p < 0.001).
Stroke symptoms noticed upon waking, wake-up stroke, account for up to a quarter of all acute ischemic strokes. Patients with wake-up stroke, however, are often excluded from thrombolytic therapy.
Migraine is reported globally with a higher prevalence in students. The present study aims to evaluate the association between nutritional status, quality of life (QL) and characteristics of migraine. A cross-sectional study. Headache characteristics, level of disability caused by migraine crises (Pediatric Migraine Disability Assessment - PedMIDAS) and QL (Pediatric Quality of Life Inventory- PedsQL) were assessed. Anthropometric variables were also measured.