Articles Related to TIA

Moringa leaf (Moringa oleifera) is referred to as the “natural nutrition of the tropics”, and in the Philippines, as “mothers’ best friend”. It possesses many health benefits and is also used in disease prevention and therapy. The enhancement of moringa’s natural potency is a scientific challenge that has yet to be thought of. We found enhanced inherent characteristics in the moringa leaf by irradiating using our recently invented 2-6µm mid-infrared ray generating atomizer (MIRGA). The achieved benefits were a more desirable taste and aroma, and an enhanced shelf life, thus increasing the potential transportation distance, quality, and palatability. This scientific achievement was supported by suitable instrumentations and sensory evaluation

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In the last decade, neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease, and various forms of Dementia) have become a challenging problem facing contemporary society, placing on it a strong economic, social, and healthcare burden. Despite huge and long-lasting efforts, the progress in solving these problems remains unsatisfactory

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The vibrations of carbon nanotubes under the influences of various internal and external forces have been subjects of interests for some years. These researches have not really considered the effects of surface energy and initial stress which are very important from both material and mechanical aspects of views. Therefore, the current study presents the simultaneous impacts of surface energy, initial stress and nonlocality and other various parameters on the nonlinear vibration of carbon nanotube hot fluid-conveying resting on elastic foundations in a magnetic environment. The derived equations governing the behaviours are solved using Galerkin’s decomposition-Adomian decomposition method is adopted to explore the concurrent impacts of surface elasticity, initial stress, residual surface tension and nonlocality on the nonlinear vibration of singlewalled carbon conveying nanotube resting on linear and nonlinear elastic foundation and operating in a thermo-magnetic environment

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The BDNF/TrkB signaling is a robust regulatory feature of neuronal cells that promotes survival, differentiation, and proliferation in a variety of cell types and animal models for neurodegenerative diseases. The activation of TrkB by BDNF in clinical trials is accompanied by remarkable side effects and appears to be challenging due to BDNF's adverse molecular profile

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Large numbers of nations are associated with utilization of anti-toxins regardless of remedy (OTC medications). This DDD/ ATC value contributes to improved antibiotic use quality. The principal objective is to direct improvement of sane medication use of strategies and to give a standard technique for information for future evaluation.

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Respiratory Syncytial Virus is an etiological cause of lower respiratory tract infections. Due to the controversial therapeutic approach, it has a significant share in the causes of hospitalizations and even fatal outcomes concerning children up to two years of age. The elderly patients, especially the immune compromised and those with co-morbidities, are at a great risk of developing severe conditions because it is often not considered as pathogen. Those are the reasons which determine the necessity of prophylaxis of the abovementioned target groups of patients - children up to two years of age and adults over 65 years of age.

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Supraventricular tachycardia is the most common type of tachyarrhythmia seen in childhood. First-line treatments (adenosine, esmolol-propranolol, digoxin, electrical cardioversion) usually suppress tachycardia, but rarely tachycardia is resistant and requiring Class IC and/or Class III agents, such as amiodarone, sotalol, propafenone, and flecainide.

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Pathologists are frequently involved in the diagnosis of sarcoidosis on conventional biopsies and cytology specimens. Histology generally does not pose difficult tasks in the correct clinical and imaging scenario, but atypical forms of sarcoidosis exist, and in these cases, the diagnosis may become difficult. The final diagnosis always requires the careful integration of the histology with the clinical, laboratory, and radiologic findings. The differential diagnoses of sarcoidosis includes granulomatous infections, hypersensitivity pneumonitis, pneumoconiosis, autoimmune diseases, drug reactions, chronic aspiration, and even diffuse fibrosing diseases. In this study, we discuss the histomorphological aspects of Sarcoidosis, along with radiological, biochemical and clinical aspects. The most important finding is the presence of non caseating granulomas by histology which needs to be interpreted in the light of appropriate clinico-radiological and laboratory findings. This study emphasises the role of the pathologist and discusses the differential diagnosis.

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Using kinetic differential equations and the Runge-Kutt algorithm, an analysis of the pathological processes occurring in the course of Alzherimer’s disease was carried out. Thanks to the appropriately selected kinetic equations, the presented model allows to explain the time course of the growth of pathological proteins: beta-amyloid and tau protein and the related loss of nerve cells. The model is based on previous experimental knowledge of Alzherimer’s diseas and is in good agreement with the experimental data.

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This study is an attempt to emphasize the prevalence of severe anemia in pediatric age group and characterize different clinical and Hematological findings among them. Anemia is a major global health problem, especially in developing countries like India, despite the fact that this problem is largely preventable & easily treatable. It leads to morbidity and mortality in children and establish a public health problem of substantial importance.

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Penicillin and streptomycin are the most commonly used to prevent bacterial infection or contamination in cell culture. However, the role of Penicillin-streptomycin on inducing mouse embryonic stem cells(mESCs) to differentiate into cardiomyocytes is unclear. To illustrate the mechanism of penicillin-streptomycin on inducing mESCs differentiation into cardiomyocytes, we firstly investigated mESCs differentiation into cardiomyocytes by the traditional method. The time- space expressions of cardiac-specific genes were detected by real-time PCR and western blotting at 8 different time-points over a period of 36 days. Furthermore, action potentials were measured by patch clamp for mESC-derived cardiomyocytes. Embryonic bodies through hanging drop method, were incubated with penicillin-streptomycin (P/S) at different concentrations (1×PBS, 1×, 2×, 5×), and then, the number of cardiomyocytes and expression levels of myocardial marker proteins were detected by flow cytometry, cellular immunofluorescence, and western blotting, respectively. We found that the SSEA-1 of mESC presented green fluorescence, and H.E. staining showed karyoplasmic ratio >>1. Besides, TNNI3, TNNT2, ACTN2 and MYL-2v were clearly visible by cellular immunofluorescence. Furthermore, the ACTN2 positive cells rate of 2× and 5× groups were remarkably higher than that in Cntl (1×PBS) group and 1× group (10 Units/mL penicillin; 10 μg/mL streptomycin), as well as the expressions of GATA4, MYL-2v, TNNI3, ACTN2

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The European Association of Urology currently recommends partial nephrectomy as the preferred management for localised cT1 renal tumours, irrespective of surgical approach. With the advent of robotic assisted partial nephrectomy, there is growing evidence that warm ischaemia time may be reduced compared to the traditional laparoscopic approach.

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Osteoarthritis is an inflammatory-degenerative joint disease that affects the osteochondral unit with the concomitant intervention of the immune system; this causes pain and progressive functional limitation. With a varied and complex etiopathogenesis, Osteoarthritis has a subtle outcome and an inexorable evolution towards joint deformity. The therapeutic approach makes use of non-pharmacological and pharmacological aids. Pharmacological therapy consists of symptomatic drugs that act on acute and especially chronic pain, in an attempt to decrease the incidence of any structural damage to the cartilage and subchondral bone. If the anti-resorptive drugs cure the subchondral-epiphyseal osteometabolic pathology, the interventions on the cartilage have not produced important and well evaluable results, even after prolonged therapies. This contribution analyzes the profile of Clodronate, used for the treatment of subchondral bone edema in Osteoarthritis, regarding its potential protective effects in cartilage, like DMOADs.

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Prolong mattress use compresses the metal coil springs which may ultimately result in a compromised sleeping surface. This coil spring metal fatigue can result in spinal pain and stiffness. The purpose of this study was to compare the amount of metal fatigue of used mattress coil springs from the areas bearing greatest body weight versus areas subjected to little compression to ascertain the. Six weight bearing coil springs (WBS) were extracted from the center the used (range 8-10 yr.) mattresses (N=32) and six non-weight bearing coil springs (NWBS) were extracted from the head/foot are of the same mattresses. To determine spring weakness a special frame and platform was constructed to compare unloaded spring height with compression distance height following placement of a 1,296 g ingot on the platform. Also, a pressure gauge was used to measure the amount of pressure required to compress the coil springs a distance of 2 cm. Comparison between WBS and NWBS data were statistically treated using independent t-tests and a one-way ANOVA. There were no significant group differences in weight or height in unloaded coils. However, there were significant (p<0.05) differences in coil spring compression distance under load (WBS = 2.78 ± 0.34 cm; NWBS = 1.52 ± 0.39 cm) and force gauge compression (WBS = 1090.51 ± 88.42 g; NWBS = 1213.12 ± 71.38 g) between groups. While manufacturers’ recommendations to replace a mattress is ranges between 8 and 10 yrs., these results indicate that coil spring weakness may occur before 8 yrs. of use. Weak springs leads to loss of weight bearing capacity of the mattress thereby resulting in sagging upon use. Such sagging which may compromise sleep posture with accompanying back pain and poor sleep quality and quantity.

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Hyperglycaemia is a key symptom in diabetes mellitus associated with long term damages, dysfunction and eventually failure of organs, especially the eyes, kidneys, nerves, heart and blood vessels. This study is to evaluate the hypoglycaemic potential of orally administered aqueous and ethanol extracts of Zyziphus spina-christ fruit on alloxan induced hyperglycaemic Wistar rats. The plant was extracted using maceration using aqueous and 80% ethanol as extraction solvents. Qualitative phytochemical analysis was done. An in vitro assessment of both aqueous and ethanol extract to demonstrate hypoglycaemic activity via inhibition of alpha amylase enzyme and alpha glucosidase enzymes were done. Total of 45 albino rats were used in the study of both sexes divided in 9 groups. Group 1: normal control group, group 2: diabetic control group, group 3: positive control group (metformin 300mg/kg), group 4-6: (150mg/kg, 300mg/kg and 600mg/kg) aqueous extract and group 7-9: (150mg/kg, 300mg/kg and 600mg/kg) ethanol extract. Groups were compared using one way ANOVA for significant differences and Dunnet’s posthoc test was deployed were differences exit. Data were represented as mean ± SEM and p value <0.005 The aqueous and ethanol extract yielded 35.59%% and 46.68% respectively. Phytochemical analysis revealed the presence of alkaloids, flavonoids, terpenoids, tannins, Saponins, Saponins glycosides, steroids, Phytosteroids, carbohydrate and volatile oil. An in vitro assessment of aqueous and ethanol extract demonstrated hypoglycaemic activity via inhibition of both alpha amylase enzyme and alpha glucosidase enzymes. The percentage inhibition of alpha amylase was presented as IC50 of 0.14, 0.19 and 0.58 for the acarbose, ethanol extract and aqueous extract respectively. Alpha glucosidase inhibition was represented by the IC50 of 0.7mg/ml, 0.9mg/ml and 0.7mg/ml for acarbose, ethanol extracts and aqueous extracts. The aqueous and ethanol extracts significantly decrease the blood glucose level. Elevation of cholesterol and LDL was seen in diabetic control group. The results from the studies showed that Ziziphus spina-Christi fruit aqueous and ethanol extracts has an anti-hyperglycaemic potential which is not a dose dependent both in Vitro and in Vivo. Ziziphus spina-Christi fruit aqueous and ethanol extract also causes a significant reduction in cholesterol level.

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Two basic reactions occur during the anodizing of aluminum: 1) the aluminum is consumed and 2) an oxide grows. By accepting this statement as true, the anodizing process can be viewed as a corrosion process, and anodizing can be modeled using the Tafel Equation. Anodizing process parameters of electrolyte chemistry and concentration, temperature, aluminum substrate resistance and current density are presented as they relate to the Tafel Equation and how they impact the anodic aluminum oxide structure and properties. Understanding this relationship is consequent in making anodizing an engineering process, one that enables tuning the structure such that it yields distinct characteristics to fulfill design and application requirements.

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We investigated a method for preparation of ordered nanopore arrays with the interpore distance of 60 nm by guided self-organization of anodic aluminum oxide with a prepatterned array of pits in the starting Al film.

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