Articles Related to Therapeutics
Potential COVID-19 Therapeutics: A Perspective on Pharmacological Properties and Safety
There are no guidelines for pharmacological treatment of COVID-19 disease, but several drugs are being tested every day in search of an optimal therapeutic strategy.
The drugs that have been tested, so far, include some antiviral drugs such as danoprevir, favipiravir, darunavir, nelfinavir, remdesivir, umifenovir and the combination lopinavir/ritonavir. Others are drugs targeting inflammatory mediators such as meplazumab, siltuximab, tocilizumab, azithromycin and corticosteroids. Also included in this array of tested drugs are those with pleiotropic actions against SARS-CoV-2 infection like chloroquine/hydroxychloroquine, ivermectin and nitazoxanide, postulated as inhibitors of several phases of virus life cycle.
Upon diagnosis of SARS-CoV-2 infection, it is pertinent to embark on a treatment approach based on potential antiviral options, adequately managed under proper medical situation. We suggest that, in addition to the antiviral option efforts, drugs targeting inflammatory mediators should be considered.
Iatrogenic Laryngotracheal Stenosis in Children: a Case Report
Laryngotracheal stenosis is one of the important causes of pediatric airway obstruction, and the etiology can be classified as
congenital and acquired. With the widespread use of tracheal intubation and tracheotomy in pediatric emergency, iatrogenic
laryngotracheal stenosis is gradually replacing trauma and infection as the major cause of acquired laryngotracheal stenosis [1].
Nowadays, open surgery is the first choice for severe laryngotracheal stenosis cases [1,2]. Here, we describe a case of childhood
iatrogenic severe laryngotracheal stenosis, and the reflection on the current treatment methods of children with laryngotracheal
stenosis.
Modified and Combined Lateral and Posterolateral Approach an Alternative Treatment to Tibial Plateau Fractures
The selection of a surgical approach for the treatment of tibia plateau fractures is an important decision. Approximately 7% of all tibia plateau fractures affect the posterolateral corner. Displaced posterolateral tibia plateau fractures require anatomic articular reduction and buttress plate fixation on the posterior aspect. These aims are difficult to reach through a lateral or anterolateral approach. The standard posterolateral approach with fibula osteotomy and release of the posterolateral corner is a traumatic procedure, which includes the risk of fragment denudation. Isolated posterior approaches do not allow sufficient visual control of fracture reduction, especially if the fracture is complex. Therefore, the aim of this case report was to present a surgical approach for posterolateral tibial plateau fractures that both protects the soft tissue and allows for good visual control of fracture reduction. The approach involves a lateral arthrotomy for visualizing the joint surface and a posterolateral approach for the fracture reduction and plate fixation, which are both achieved through one posterolateral skin incision. Using this approach, we achieved reduction of the articular surface and stable fixation in patients at the final follow-up visit. No complications and no loss of reduction were observed. Additionally, the new posterolateral approach permits direct visual exposure and facilitates the application of a buttress plate. This approach does not require fibular osteotomy, and fragments of the posterolateral corner do not have to be detached from the soft tissue network.
Perspectives and Potential Applications of Ruthenium-Based Nanocarriers for Cancer Therapy
Cancer is a highly heterogeneous disease characterised by continuous uncontrolled growth and expansion of abnormal cells. In general, in tumor cells the signalling pathways regulating cellular processes, as cell growth and division and cell to cellcommunication result strongly altered.
Topical Delivery System for Phytochemicals: Capsaicin and Capsicum Tincture
Capsaicin, an active ingredient of Capsicum fruit, is currently undergoing “revival” in the clinical management of pain. However, the choice of its formulation is rather limited to the use of “old-fashioned” tinctures and recently the patches. In an attempt to improve the therapeutic outcome and develop its skin-friendly formulation, we prepared the vesicle-based drug delivery system with capsaicin.
Editorial Board Members Related to Therapeutics
Azad Kumar Kaushik
Associate Professor
Department of Immunology
University of Guelph
Canada
Department of Immunology
University of Guelph
Canada
Yasuo Iwasaki
Professor
Department of Neurology
Toho University Omori Hospital
Japan
Department of Neurology
Toho University Omori Hospital
Japan
Dong-Hua Yang
Assistant Professor
Fox Chase Cancer Center
United States
Fox Chase Cancer Center
United States
Mohammad Ayoub Mir
Assistant Professor
School of Medicine
University of Kansas
United States
School of Medicine
University of Kansas
United States
Lufang Zhou
Lufang Zhou
Assistant Professor
The University of Alabama
Birmingham
United Kingdom
Assistant Professor
The University of Alabama
Birmingham
United Kingdom
PAULA M. CHILTON
Assistant Professor
Department of Microbiology & Immunology
University of Louisville
United States
Department of Microbiology & Immunology
University of Louisville
United States
Jason J. Guo
Associate Professor
Center for Drug Discovery
Northeastern University
United States
Center for Drug Discovery
Northeastern University
United States
Jeffrey Michael Venstrom
Assistant Professor
Department of Medicine
University of California, San Francisco
United States
Department of Medicine
University of California, San Francisco
United States
Suman Sirimulla
Assistant Professor
Department of Basic Sciences
St. Louis College of Pharmacy
St. Louis, MO
United States.
Department of Basic Sciences
St. Louis College of Pharmacy
St. Louis, MO
United States.
Zafar K. Khan
Professor
Department of Microbiology and Immunology
Drexel University
United States
Department of Microbiology and Immunology
Drexel University
United States