Articles Related to Toxicological Screening
Methadone and Torsade De Pointes in the Therapeutic Range
Methadone, a long-acting opioid agonist, binds to and occupies mu-opioid receptors, preventing withdrawal symptoms for 24 hours or longer, reduces craving for opioids, and, by maintaining high levels of opioid tolerance, reduces the euphoric effects of subsequent illicit opioid use. As a controlled substance with potential for abuse, methadone use is regulated in the US and other countries.
Toxicological Screening and Quantitation Using Liquid Chromatography/Time-of-Flight Mass Spectrometry
In recent years, an increasing number of new designer-drugs have increased the demands for general toxicological screening [1]. Limited screening based on immunoassays is commonly used in clinical toxicology, whereas more comprehensive approaches are common in forensic toxicology such as screening based on Gas or Liquid Chromatography (GC or LC) approaches.