Articles Related to Transdermal Drug Delivery

The transdermal drug delivery system is technique that provides drug through the intact skin. Skin penetration enhancement techniques have been developed to increase the bioavailability of drug substance. These review describes various transdermal patches available in market, types of patches, basic components, polymer used in formulation. The novel drug delivery method do well and complete with those already on the market the main problem that requires consideration include device design and safety, efficacy, ease of handling and economical. Transdermal drug delivery system represent the most attractive method among these because of its low rejection rate, magnificent, ease of administration and better convenience and compliance with patient. This review article provide an overview of transdermal drug delivery system contains various innovative dosage forms. In comparison transdermal patch are effective due to its easy to apply and non-invasive.

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Transdermal drug delivery system has become a proven technology that offer significant clinical benefit over the dosage forms. Drugs with very short half-life, narrow therapeutic window, and poor bioavailability-transdermal drug system are convenient. Skin serves as site of drug application for local as well as systemic effects. There are wide varieties of drugs for which topical or transdermal is viable options

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The currently available anti HIV agents have several drawbacks such as short half life, low bioavailability, poor CNS penetration and retention, hepatic first pass metabolism, undesirable side effects and frequent dosing regimen.

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Recently, transdermal drug delivery system (TDDS) has become a more and more important approach to administering drugs. Based on its advantages, which are not achievable by other modes of administration, many researchers are dedicated to the study of it, and have made great progress. Although the skin offers a painless interface for systemic drug delivery, it also presents limitations which are mainly caused by the stratum corneum.

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