Articles Related to amphetamine
Today, both nonprescription and prescription drugs used by people for disease treatment, illicit or reward purposes have diverse effects on health permanently or long-lastingly. The effects may even continue and lead to the death or disabilities in child when a person is no longer use the substance. Substances that cause addiction trigger intense feeling of euphoria then lead to loss of control of self-behavior and perception.
Methamphetamine is one of the most commonly abused illegal stimulants and causes the release of dopamine, norepinephrine and serotonin. These neurotransmitters trigger vasospasm, causing persistent tachycardia, hypertension, and direct myocardial toxicity. Moderate usage of methamphetamine can increase cardiac output and myocardial contractility. However, larger doses can cause depression of the myocardium.
Identification of Designer Drugs using Gas Chromatography High-Resolution Mass Spectrometry and a Soft-Ionization Source
Gas chromatography-mass spectrometry (GC-MS) with electron ionization (EI) or chemical ionization (in positive or negative mode) plays an important role in the forensic analysis of designer drugs.
An Ultra-High Pressure Liquid Chromatography Time-of-Flight Mass Spectrometry (UHPLC-TOF-MS) method for quantitative analysis of 30 drugs in whole blood was developed and validated. The method was used for screening and quantification of common drugs and drugs of abuse in whole blood received from autopsy cases and living persons.