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Articles Related to infection

A Retrospective Evaluation of Joint Endoprosthesis Infections and Depending Costs

Joint endoprosthesis are standard treatment in orthopedic surgery, but the risk of infection represents a major drawback for elderly patients with comorbidities. Therefore, we investigated joint endoprosthesis infections in Germany (2005-2012) focusing on elderly patients. We extrapolated infection related costs to estimate the burden for the health care system.
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Caenorhabditis elegans (C. elegans) Used as a Whole Model Organism to Identify New Anti-Infectives Therapeutic Agent for MRSA Pathogens - A Review Paper

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the greatest fears with the number of serious infections on human health regarding antibiotic resistance. It causes a wide range of infections and bacteremia, ranging from inconsequential superficial skin infections, wound suppuration, even pneumonia or deep-seated tissue infections, which may lead to sepsis and fatalities.
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Modelling the Force of Infection for Hepatitis B among Heterogeneous Groups at the Komfo-Anokye Teaching Hospital

The aim of this study is to estimate the age-dependent force of infection for hepatitis B virus (HBV) for sick patients showing symptoms, blood donors and people coming to the serology department to test for the antigen in blood voluntarily. A secondary data was obtained from the serology department at the Komfo Anokye Teaching Hospital (KATH, January 2013- June 2016).
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Efficacy and Safety of Moxifloxacin-Enhanced versus Standard Sequential Eradication Therapy for Treating Helicobacter pylori Infection among Tobacco Smokers

The therapeutic failure rate of eradication therapy for Helicobacter pylori (Hp) is increasing due to bacterial resistance; tobacco smoking can increase such a rate even more. We explored the role of adding moxifloxacin to the standard sequential eradication therapy for Hp in decreasing the therapeutic failure rate among the tobacco smokers.
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The Effect of Bundled Interventions on Prevention of Hospital Acquired Clostridium Difficile Infection: An Integrative Review

Hospitalized patients are at an increased risk for acquiring Clostridium Difficile Infection (CDI). Increased virulence of C. difficile strains and increased use of antimicrobials have led to an increase of CDI cases that are more difficult to treat (CDC, 2013). Proper hand hygiene techniques, room cleaning, and equipment cleaning are not consistently being followed by healthcare workers, leading an increased spread of CDI between hospitalized patients. The purpose of this integrative review was to determine the best evidencebased methods to reduce hospital-acquired CDI rates. The evidence reviewed supports the implementation of a multifaceted approach including: (a) proper hand hygiene practices, (b) adequate and appropriate surface cleaning practices, (c) compliance to contact isolation procedures, and (d) strengthening of an existing antimicrobial stewardship committee to reduce hospital-acquired CDI rates.
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Dawn of the Biofilm Disease: Highlights about Biofilm in Bone and Joint & Prosthetic Joint Infections Pathogenesis, Diagnosis and Treatment

I present some key considerations of the biofilm disease as part of two complex pathologies such as bone and joint infections and prosthetic joint infections, taking into account the bacterial pathogenic factors to understand the particular nature of these infections, and to achieve an accurate diagnosis and management beyond the antimicrobial therapy. I mention some personal experience of many years in the medical microbiology laboratory and next to the patient’s bed.
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The Efficacy and Safety of Prophylactic Fluconazole Prevent Invasive Fungal Infection in Preterm Very Low Birth Weight Infants: An Update Meta-analysis

We identified 8 eligible trials that enrolled 1392 infants. There was significant effect of prophylactic fluconazole on fungal colonization (RR, 0.31, 95%C1:-0.24 to 0.41; P<0.00001). Effect of prophylactic fluconazole on IFI in VLBW infants: RR: 0.42(95%CI 0.23 to 0.76; P=0.004.). However, prophylactic fluconazole did not reduce mortality in VLBW infants (RR 0.76, 95% CI 0.58 to 1.01; P = 0.06). Studies did not report significant adverse reactions.
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S. Pneumoniae Infection Associated with a Hemolytic Uremic Syndrome in an Adult Patient: A Case Report

Hemolytic uremic syndrome (HUS) is a rare but severe entity characterized by the triad of acute kidney injury, microangiopathic hemolytic anemia, and thrombocytopenia. This disease is frequently observed in children after a diarrhea process secondary to Escherichia coli O157: H7. However, other disturbs may generate this disease, including pneumonia secondary to S. pneumoniae, which represents around 5% of all HUS cases. This type of HUS has demonstrated an increase in incidence in the population recently.
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Cell Culture, Cytopathic Effect and Immunofluorescence Diagnosis of Viral Infection

Viruses are obligate intracellular parasites that require living cells in order to replicate. Cell culture for propagation and identification of viruses is an important component of the clinical virology laboratory. In general, diagnostic tests can be grouped into three categories: direct detection, virus isolation and serology. Direct examination methods can usually give a result either within the same or the next day. Immunofluorescence is widely used for the rapid diagnosis of virus infections by detection of virus antigen in clinical specimens and detection of virus-specific antibodies.
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Development of Acute Implant Peri-Implantitis After Immediate Implant Loading: A Case Report

implantitisIntroductionThe acute apical peri-implantitis (AAPI) is defined as a clinically symptomatic periapical lesion that develops shortly after implant insertion while the coronal portion of the implant substains a normal bone-to-implant interface. The etiology of AAPI is unclear. Regardless of etiology, the management of AAPI has been attempted by either respective or regenerative techniques.
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Protocol for Root Canals’ Irrigation in Endodontic Practice in Ivory Coast: A Survey of 100 Dentists

In endodontics, a chemo-mechanical preparation is used to disinfect the root canal system. However, due to limitations of endodontic devices, which shape the main canal, this preparation is supplemented by irrigation solutions. In Ivory Coast, late consultations and advanced stages of pathologies characterized the endodontics.
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Treatment of Cerebral Mucormycosis with Prolonged Liposomal Amphotericin B (>1000 days)

Mucormycosis is a rare but invasive and potentially lethal infection caused by ubiquitous fungi of the order Mucorales. The primary mode of infection is inhalation of fungal spores. Rhinocerebral and pulmonary infections are most common, however, other organ systems including the central nervous system can be affected, presumably by occult fungemia. We describe the prolonged treatment course (>1000 days) of a patient with cerebral mucormycosis using liposomal amphotericin B (LAMB). Two different attempts were made to replace LAMB with posaconazole, but each occasion resulted in therapeutic failure. This case represents the longest course of LAMB reported in the literature.
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Predictors of Delayed Diagnosis and Evolution in Sub-Saharan Immigrants with HIV Infection in a Hospital in Madrid (2004–2013)

The aim of this study was to analyze the delayed diagnosis and evolution of HIV infection in predominantly sub-Saharan immigrants compared to other patients in a hospital in Madrid between 2004 and 2013. We retrospectively analyzed new HIV diagnoses. Late presentation or advanced disease were considered the presence of CD4 lymphocyte counts less than 350 or 200 cells/µl at diagnosis, respectively, or an AIDS-defining disease regardless of the CD4 count. Patients were compared according to their origin and sex.
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Gross and Histopathological Alterations in Experimental Trypanosoma Evansi Infection in Donkeys and the Effect of Isometamidium Chloride Treatment

Trypanosoma evansi (T. evansi) infection causes wasting and fatal animal trypanosomosis. This study was aimed at determining the gross and histopathological alterations in donkeys experimentally infected with T. evansi and the effect of isometamidium chloride treatment. Apparently healthy donkeys (N=18) of mixed sexes were randomly assigned to 3 groups; A1 (Infected-untreated), A2 (Infected, isometamidium-treated) and B (Uninfected, control) of six animals each. Each animal in infected groups had about 2.0x106 T. evansi injected through the jugular vein. Parasitaemia levels were evaluated using HCT and Mice Inoculation Test (support test). Gross and histopathological examinations were also conducted post-infection and post-treatment.
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Awareness of Cervical Cancer Risk Factors, Screening Practices and Attitudes among Nurses in a Primary Health Care Setting of Morocco: A Cross-Sectional Study

The effectiveness of the cervical cancer screening activities depends on physicians and nurses’ level of awareness and their adherence to the program.
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Editorial Board Members Related to infection

Inam Danish Khan

Indian Army Medical Corps
Department of Pathology
Command Hospital
India

Zafar K. Khan

Professor
Department of Microbiology and Immunology
Drexel University
United States

Rajiv Saini

Associate Professor
Department of Periodontology & Oral Implantology
Pravara Institute of Medical Sciences – Loni
India

Helena Nunes Cabaco

Research associate
Institute of Molecular Medicine
Faculty of Medicine
University of Lisbon
Portugal

ELENA A. USACHEVA

Assistant Professor
Department of Pathology
University of Chicago Pritzker School of Medicine
United States

Seham Bassyouni M. Tayel

Professor
Department of Prosthetic Dentistry
Faculty of Dentistry
Alexandria University
Egypt

Hisao Kurazono

Professor
Department of Animal and Food Hygiene
Obihiro University of Agriculture and Veterinary Medicine
Japan

Ashraf Eljedi

Associate Professor of International Public Health
Faculty of NUrsing
The Islamic University of Gaza
Palestine

HamidReza Naderi

Associate Professor
Department of Infectious Diseases
Imam Reza University Hospital
Iran

Andrew W. Taylor-Robinson

Professor of Immunology & Haematology
School of Medical & Applied Sciences
Central Queensland University
Australia
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