Articles Related to mass spectrometry

This review focuses on imaging, visualization and detection of diseases using nanoprobes. Several currently available nanoprobes such as fluorescent nanoprobes, upconversion nanoparticle probes, supermagnetic iron oxide nanoprobes, and polymer- and liposome based nanoprobes are discussed.

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Eugenol (EU) and ibuprofene (IBU) were covalently bound to a bi-functionalized PEG, used as molecular carrier of drugs and the release kinetics of the two bioactive molecules was studied in vitro in buffer solution at pH 7.4, in simulated gastric fluid and in mouse plasma.

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In the post genomic era when several proteomes are on the verge of completion, promising field of protein based diagnostic techniques is emerging. Although protein detection have been used for a long time in clinical diagnostic test, yet high throughput proteomics approaches along with systems biology could be a step forward, towards the development of next generation diagnostic tools and pave a way for personalized medicine.

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A series of differentiated 2-chloroquinoline derivatives (3-26) having various spacer groups between 2-chloroquinoline and aryl or heteroaryl ring were synthesized by chemical reactions involving nucleophilic addition, nucleophilic substitution, esterification and cyclization.

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Use of gas chromatography (GC) combined with time-of –flight mass spectrometry (TOFMS) with soft ionization generated with three different plasma gases (i.e., Xe, Kr, Ar) was evaluated for the identification of several pyrrolidinophenone-type designer drugs that are commercially available.

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This study investigated comparative concentrations of individual amino acids, total amino acids (TAA), non-essential amino acids (NEA) and essential amino acids (EAA) in the blood after the administration of Rice Protein Isolate (RPI) compared to Whey Protein Isolate (WPI).

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Gas chromatography-mass spectrometry (GC-MS) with electron ionization (EI) or chemical ionization (in positive or negative mode) plays an important role in the forensic analysis of designer drugs.

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In recent years, an increasing number of new designer-drugs have increased the demands for general toxicological screening [1]. Limited screening based on immunoassays is commonly used in clinical toxicology, whereas more comprehensive approaches are common in forensic toxicology such as screening based on Gas or Liquid Chromatography (GC or LC) approaches.

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An Ultra-High Pressure Liquid Chromatography Time-of-Flight Mass Spectrometry (UHPLC-TOF-MS) method for quantitative analysis of 30 drugs in whole blood was developed and validated. The method was used for screening and quantification of common drugs and drugs of abuse in whole blood received from autopsy cases and living persons.

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A reliable, fast, sensitive and selective Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) method has been developed and validated for the determination of fenofibrate in marketed product (Lipanthyl) and human plasma. The chromatographic separation was performed on a reversed-phase Acquity®BEH C18 column (1.7 μm particle size, 50 mm x 2.1 mm ID) with an isocratic elution profile and mobile phase consisting of methanol and water (80:20, %, v/v). To achieve optimum chromatographic condition the influence of mobile phase composition and flow rate was investigated. The total chromatographic analysis time was as short as 2 min.

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