Articles Related to toxicological
Methadone and Torsade De Pointes in the Therapeutic Range
Methadone, a long-acting opioid agonist, binds to and occupies mu-opioid receptors, preventing withdrawal symptoms for 24 hours or longer, reduces craving for opioids, and, by maintaining high levels of opioid tolerance, reduces the euphoric effects of subsequent illicit opioid use. As a controlled substance with potential for abuse, methadone use is regulated in the US and other countries.
Review on Transdermal Drug Delivery Systems
Recently, transdermal drug delivery system (TDDS) has become a more and more important approach to administering drugs. Based on its advantages, which are not achievable by other modes of administration, many researchers are dedicated to the study of it, and have made great progress. Although the skin offers a painless interface for systemic drug delivery, it also presents limitations which are mainly caused by the stratum corneum.
Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins
The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.
The Flesh Fly Sarcophaga (Liopygia) crassipalpis Macquart 1839 as an Invader of a Corpse in Calabria (Southern Italy)
We present an indoor forensic case that occurred in spring 2013 in Cosenza (southern Italy). The entomological evidence collected at the scene consisted of Calliphoridae (Calliphora vicina, Lucilia sericata), Sarcophagidae (Sarcophaga crassipalpis), Fanniidae (Fannia scalaris) and Muscidae (Hydrotaea ignava).
Toxicological Screening and Quantitation Using Liquid Chromatography/Time-of-Flight Mass Spectrometry
In recent years, an increasing number of new designer-drugs have increased the demands for general toxicological screening [1]. Limited screening based on immunoassays is commonly used in clinical toxicology, whereas more comprehensive approaches are common in forensic toxicology such as screening based on Gas or Liquid Chromatography (GC or LC) approaches.
Editorial Board Members Related to toxicological
Xiaoqing Guo
Division of Genetic and Molecular Toxicology
National Center for Toxicological Research (NCTR)
USA
National Center for Toxicological Research (NCTR)
USA
Carla J. Kinslow
Principal Consultant
Rimkus Consulting Group
USA
Rimkus Consulting Group
USA
David J. MacEwan
Professor
Department of Molecular & Clinical Pharmacology
Institute of Translational Medicine
University of Liverpool
United Kingdom
Department of Molecular & Clinical Pharmacology
Institute of Translational Medicine
University of Liverpool
United Kingdom
Juan Jose Alava
Research Associate
Faculty of Science
The University of British Columbia
Canada
Faculty of Science
The University of British Columbia
Canada
Andrés Rodríguez Seijo
Department of Plant Biology and Soil Science
Faculty of Sciences - University of Vigo
Spain
Faculty of Sciences - University of Vigo
Spain
HENGYI XU
Associate Professor
State Key Laboratory of Food Science and Technology
Nanchang University
China
State Key Laboratory of Food Science and Technology
Nanchang University
China
Kit-Lam Chan
Professor
School of Pharmaceutical Sciences
Universiti Sains Malaysia
Malaysia
School of Pharmaceutical Sciences
Universiti Sains Malaysia
Malaysia