Recent Articles

Intraocular pressure (IOP) is known to fluctuate according to a circadian rhythm. While this phenomenon has been quite extensively studied and reported in a number of species, including mice, to date, there have been few studies on the circa dian effect upon total aqueous humor outflow facility (Ctot). In this study, we measured IOP in living anesthetized C57BL/6J mice every 3h over a 24h period, using a TonoLab impact tonometer. We also measured daytime (10:00 pm to 12:00 pm) and nighttime (02:00am to 04:00am) Ctot in anesthetized living mice using a constant flow infusion method. We report that over a 24h period, IOP is highest at midnight (18.34 ± 2.79 mmHg, mean ± St Dev mean) and lowest at midday (12.71 ± 1.42 mmHg), ΔIOP = 5.63 mmHg or 44.3% increase at night, P = 0.005. We also report that Ctot at nighttime (13.66 ± 1.12 nL/min/mmHg ± SEM) is lower than corresponding measurements made during the day time (24.58 ± 2.42 nL/min/mmHg ± SEM), ΔCtot = 10.92 nL/min/mmHg, or 44.4% reduction at night, P = 0.004. In living C57BL/6J mice, IOP and Ctot exhibit circadian variation and appear to be inversely related.

Policy makers and payers are expressing a growing interest in oral health value-based payment approaches to improve the oral health care of patients. Episode of care bundles have the potential to become an important value-based approach in oral health and are already a prominent value-based approach used in health care. In this study, we design two episode of care bundles for oral health preventive services and retrospectively analyze over 16,000 visits in a pediatric dentistry clinic in an urban city in Arizona to evaluate the extent of bundle compliance. Findings from the 16-month study (May 1, 2019 September 1, 2020) indicate that approximately 61% of the Comprehensive Examination Bundles were completed in a sin gle visit while approximately 44% of the Periodic Examination Bundles were completed in a single visit. An item analysis in dicated that radiographs were the most commonly absent bundle element for both bundles with fluoride application and prophylaxis the most commonly absent bundle elements in the Comprehensive Examination Bundle.

An essential component of forensic investigations is forensic anthropology. Forensic Anthropology deals with the study of skeletal remains. When it comes to determining the cause of death and traumatic injuries, forensic anthropology is quite helpful. The investigation of several techniques for identifying traumatic injuries like blunt force trauma, sharp force trauma and gunshot wounds is the major topic of this study. These traumatic injuries are examined using various techniques. This study focuses on the detection of traumatic injuries on skeletal remains by the using visual examination, x-rays analysis, ra diography, CT scans, and photography. Among all of these techniques, visual analysis is of great importance in forensic An thropology because it offers comprehensive data for the investigation of traumatic injuries

Basal cell carcinoma (BCC) is one of the most common skin cancer and is usually found in sun-exposed areas. It generally has a favorable prognosis due to its slow growth and low metastatic potential. However, if left untreated, it can lead to the de struction of surrounding tissues. Herein, the case of a female in her 60s, with a giant BCC laying on the upper left gluteal skin. The tumor measures 12 centimeters in size, and has been neglected for over 15 years. We believe that our case is rare by its size and unusual location, as BCC only rarely occur in non-sun-exposed sites

Pilomatricoma is a benign tumor frequently found in the cervicofacial region of children or young adults. It typically mani fests as a subcutaneous nodule with a diameter not exceeding 3cm. In this article, we present a rare case of pilomatricoma with several unusual findings—a giant tumor measuring 11 cm in diameter—located on the trunk of a patient in his mid-40s. The combination of the patient's age, the tumor's location, and its size makes this case exceptional. Given the limit ed existing literature on such lesions, we believe it is crucial to shed light on atypical cases like ours

Ceftobiprole Medocaril is a fifth-generations cephalosporin indicated for the treatment of adult patients with Staphylococ cus aureus bacteremia (SAB), adult patients with bacterial skin and skin structure infections (ABSSI), and adults and pedia tric patients with community-acquired bacterial pneumonia (CABP). It provides a feasible and efficient alternative for em piric therapy

Background: Short-term outcomes of critically ill patients with hematological malignancies (HM) who developped acute kidney injury (AKI) is grim. Little is known about their long-term management. We aimed to assess the impact of the occur rence of AKI on long-term outcome and management in those patients

The Italian Penal Code, through Article 612 bis, regulates stalking by identifying it as a phenomenon wherein an individual repeatedly engages in harassing or oppressive behavior towards a victim. Today, little attention is paid to the crime of Judi cial Stalking, in which there is a reversal of roles. In such cases, the perpetrator, disguised as the victim, drags the actual vic tim into court, accusing them of various crimes with repeated unfounded compensation claims solely instrumentalized to cause psychological, reputational, and economic harm. These perpetrators are not necessarily diagnosed with a psychiatric disorder but possess personality structures characterized by strong manipulative traits and the use of primitive psychologi cal defenses

This review explores the crucial role of personalization and individualization in AI tools designed to educate autistic chil dren. Despite significant progress in AI applications in education, the existing landscape often fails to address the diverse needs of the autistic community. One significant gap in current research is the neglect of cultural and socioeconomic factors that influence learning experiences

The structure and thermal stability of Co-W alloys electrodeposited with direct and pulsed currents have been investigated by X-ray diffraction and differential thermal analyses. It has been established that amorphization of alloys is influenced by deposition modes and concentration of amorphizing component (sodium tungstate salts) (Na2 WO4) in the aqueous electrolyte solution. It is shown that with increasing tungsten content in the alloy or under more non-equilibrium conditions of electrodeposition the onset of crystallisation shifts to higher temperatures

Essential oil was extracted from the Cymbopogon citratus (Lemongrass) plant to evaluate its antifungal activity against four phytopathogenic fungi, viz., Fusarium oxysporum, Alternaria alternata, Aspergillus flavus, and Aspergillus niger, using the poisoned food technique. Different concentration of extracted essential oil viz., 500 ppm, 1000 ppm, 2000 ppm, 4000 ppm, and 6000 ppm, were used to evaluate the potential effect against tested pathogens. At the concentration of 1000 ppm, 100% inhibition of mycelial growth was observed against Alternaria alternata and Aspergillus niger, whereas at a concentration of 2000 ppm 100% growth inhibition was found against Fusarium oxysporum and Aspergillus flavus fungi, respectively. The percentage inhibition of mycelial growth of the tested fungi was found to be dose dependent. The GC-MS analysis of essen tial oil revealed 40 compounds. Among them 2,6-Octadienal, 3,7-dimethyl- (E)- (Citral), Neral (Beta Citral), 2-Pentanone, 4-hydroxy-4-methyl- (Diacetone alcohol, Geraniol (Lemanol) and Geranyl acetate were found to be major constituents. In silico studies revealed that Geranyl acetate has strong binding affinity and inhibition constant against four major fungal cell wall proteins. Thus, based on the above results it concluded that essential oil of Cymbopogon citratus could be used as an al ternative to synthetic fungicides for management of phytopathogenic fungal diseases.

Coronary artery calcification (CAC) is commonly encountered by interventional cardiologists. Severe CAC may impair stent delivery or result in stent underexpansion, stent thrombosis and/orin-stent restenosis (ISR).Adequate preparation of heavily calcified coronary lesions (e.g. using non-compliant balloons, cutting/scoring balloons, rotational/orbital atherecto my or intravascular lithotripsy) prior to stent implantation is essential in preventing stent underexpansion.However, in cer tain cases the deployed stent may remain underexpanded despite extensive lesion preparation.Recent reports have suggest ed that IVL could be used with success in patients with acute stent failure.We present a case of Acute IWMI with stent un Keywords: CAC(Coronary artery calcium),PCI(Percutaneous coronary intervention),IWMI(Inferior wall MI),IVL(Intravs cular lithotripsy),RA(rotational atherectomy),NCB(non compliant balloon) derexpansion during primary PCI due to focal dense calcification managed with IVL with good final result. Shockwave In travascular Lithotripsy (IVL) is the only technology that cracks both medial and intimal calcium while minimizing trauma to the vessel wall.In the recent past it has been indicated for denovo calcified coronary lesions and calcified Instent resteno sis.For IVL use in acute stent failure it is a off label indication.

Artificial Intelligence and Machine Learning (ML) are increasingly being used in the Neurocritical Care and healthcare in general. The ML model algorithms have many existing and potential uses in triage, diagnosis, clinical decision support, mon itoring, and prevention of clinical syndromes. Combining and appropriately analyzing the vast number of neurocritical care data parameters, ranging from clinical (including electronic medical record), laboratory, imaging, multimodal monitoring, and many others is beyond human capability. ML algorithms can help the providers and patients in analyzing these data pa rameters to address certain defined problems. Machine learning does have limitations in several aspects (technical, medi co-legal, financial, clinical, ethical, social, etc.), which can prevent realization of its full potential. Addressing these pitfalls with appropriate solutions in a timely manner is important to get the maximum benefit out of this valuable technological ad vancement

Objective: This study was explored the impact of Nihavent theme on decreasing of adaptation difficulty in patients with Alzheimer’s disease. Materials and methods: The study was conducted with a total of 30 patients, 15 patients in the intervention group and 15 patients in the control group. Before the application, The Descriptive Characteristics Data Form and Assessment Scale of Adaptation Difficulty for the Elderly were administered to both groups. The patients in intervention group had music ses sions for 12 weeks. Patients in the control group received standard care but did not participate in the specific intervention. One week after the music session completed, the Assessment Scale of Adaptation Difficulty for the Elderly was re-adminis tered to both groups.

This study examined the effectiveness of Solution-Focused Therapy (SFT) in reducing tobacco smoking dependency be haviour among incarcerated individuals within correctional settings in Oyo State. Anchored on social cognitive theory, which highlights the role of self-efficacy in behaviour change, the research was designed to address the pressing public health concern of tobacco smoking among the inmates.

Aim: The aim of this study was to generate linear anthropometric data for the design of Negroid anatomical model for fu ture standardization. Method: The research design was cross-sectional and non-experimental design. A total number of three hundred (300) sub jects were recruited between the ages of 18 to 37 years with a BMI range of 18.50 to < 30.00 for this study. Taro Yamane’s formula was used to determine the minimum sample size. BMI and linear body anthropometric measurements were taken using a stadiometer, calibrated flexible meter tape, meter rule, and weighing scale. Data were analyzed using SPSS for dis crete statistics and t-tests of significance

Background: Erectile dysfunction in diabetic males is considerably high, but it is often underdiagnosed and under-man aged. Identifying the status and risk factors of erectile dysfunction is important in sexual quality of life and maintaining part ner relationships. Objectives: To assess erectile dysfunction and associated factors among adult diabetic males attending Jimma Medical Cen ter from May 15 to June 15, 2023

The aim of the study was to generate linear craniofacial anthropometric database for Ijaws resident in Port Harcourt using photogrammetry. Methods: The study involved 300 subjects (150 males and 150 females) between the ages of 18 to 40 years randomly selected from Port Harcourt environs. Direct anthropometric and photogrammetric methods were used in this study. Frontal and lateral view photographs of the subjects taken in the natural head position were analyzed using Pro Image facial analysis soft ware. Seven craniofacial parameters were measured and the data analyzed using Statistical package for social science (SPSS) version 25.0

The mucocutaneous junction (MCJ) is a specific site located at body orifices such as the lip and mouth, nasal orifice, eyelid, vulva, prepuce and anus. The present review was conducted to show the similarity and difference among these sites of the MCJ in terms of 1) cytokeratin expression, 2) the distribution of immunoreactive cells, 3) nerves and terminals, and 4) site specific cell lineage and other features. In near-term fetuses, routine histology clearly demonstrated the putative MCJ due to a transient, thick stratification of the epithelium. This was most evident in the oral mucosa and less evident in the palpebral skin. In the anus and eyelid, the MCJ developed from highly proliferative epithelia of future glands, independent of the growing skin and mucosa of a simple origin from the surface ectoderm. In elderly individuals, the MCJ was expanded in the nose and anus possibly as a result of mechanical stimuli, and was apparently connected to a hemorrhoid venous plexus. At the vulva and prepuce, a morphology intermediate between pseudostratified columnar and stratified squamous epithelia was evident at near-term. Except for the vulva and prepuce, corpuscle-like nerve terminals were sandwiched between the dermal papillae and epidermis, whereas nerves arranged in parallel exhibited free ends beneath the mucosa. Langerhans cells were richly distributed in the skin stratum spinosum, while suppressive T lymphocyte clusters were present in the lami na propria mucosae. Those observations might teach us that the lip does not show a general morphology

The purpose of this investigation was to compare the efficacy of a combination of Salacia chinensis extract, citrus bioflavonoids, and trivalent chromium (SEC) on glucose and insulin control, psychobiological perceptions of hunger, and adverse events reported from 12 weeks of supplementation. Using a randomized, double-blind, placebo-controlled parallel group study design, subjects were randomized to consume SEC or a placebo (PLA). Participants completed two study visits (baseline and after 12 weeks of supplementation) where they were assessed for glucose and insulin changes after an oral su crose tolerance test (OSTT), perceptual indicators of hunger and appetite, waist circumference, and clinical biomarkers of metabolic and physiological function associated with glucose and insulin control. Twelve weeks of SEC supplementation sig nificantly reduced cravings for sweets, reduced insulin and glucose responses to an OSTT, and increased adiponectin levels. Improvements in BUN: creatinine ratio provides preliminary support for maintaining healthy kidney function. These re sults support the role of botanical supplements in improving outcomes associated with obesity, metabolic health and glu cose intolerance