Recent Articles

The application of AI has become known as a disruptive technology in a variety of industries, and its possible application in the field of law enforcement has gained traction. The purpose of the aforementioned study is to investigate the reach of artificial intelligence in the field of criminal justice, focusing on its possible benefits, problems, and ethical implications. This study sheds light on the existing and potential consequences of AI within the court system by examining a variety of use cases such as predictive law enforcement, profiling of offenders, proof evaluation, and legal investigation

Plasmodium parasites, which cause malaria, continue to pose a serious threat to global health, necessitating the continuous search for novel antimalarial agents. Entada africana is a plant known for its ethnomedicinal uses in treating various ailments associated with inflammation including malaria. Due to its reported antiplasmodial potentials, we studied the effect of the methanol bark extract of the plant. HPLC chromatogram of the methanol bark extract showed the presence of eight phyto-compounds namely coumaric acid, gallic acid, catechin, ferulic acid, quercetin, apigenin, rutin, and kaemferol. Thus, the study aimed at evaluating the antiplasmodial potential of methanol bark extract of Entada africana (MBEEA) through heme polymerase inhibition via in silico approaches. The in silico studies showed favourable binding affinities and stable interactions with heme polymerase, with rutin (-9.9 kcal/mol), apigenin (-8.0 kcal/mol) and catechin (-7.8 kcal/mol) having higher binding affinities compared to the standard drug, chloroquine (-6.7 kcal/mol). Hydrogen bond analysis reveals that ferulic acid (Asp 77, Ile 73 and Ala 29) and kaemferol (Arg 40, Arg 27 and Leu 74) form three hydrogen bonds. On the other hand, compounds like coumaric acid (Ala 291 and Arg 27), gallic acid (Ala 29 and Ser 76), catechin (Arg 40 and Arg 40), and quercetin (Ser 76 and Ser 76) form two hydrogen bonds with the amino acid residues, rutin forms two hydrogen bonds with Ser 76 and Leu 74, while apigenin forms one hydrogen bond with Arg 27 when compared to the standard drug, chloroquine (-6.7 kcal/mol) which forms no hydrogen bonds with the amino acid residues. Based on their pharmacokinetic characteristics, safety profiles, and appropriate drug-like ability, seven compounds were shown to have antiplasmodial properties by computational ADMET tests

Chronic kidney disease (CKD) is now a global public health epidemic with increasing rates reported all over the world. Currently, more than 850 million people are estimated to live with CKD worldwide. Bone and mineral disorders (CKD-MBD) form an integral part of the management of CKD patients. CKD-MBD encompasses distinct abnormal pathology within the spectrum of Renal Osteodystrophy (ROD), including osteitis fibrosa cystica, osteomalacia, adynamic bone disease (ABD), mixed lesions, and osteoporosis. ABD is primarily characterized by decreased or absent bone formations along with low cellularity of both osteoblasts and osteoclasts as well as thin osteoid seams and minimal or absent peri trabecular/marrow fibrosis. ADB is also associated with a greater risk of vascular calcification and fractures negatively affecting patient outcomes. It is unclear if all forms of ABD are truly pathological or milder forms of ADB could be a compensatory mechanism to guard against bone loss. In this article, we describe a hemodialysis patient profile of ADB with a review of this entity

In this research work, a new class of heavy-tailed mixture cure rate models; Type 1 Heavy-Tailed Gamma (T1HT-G) mixture cure rate model was introduced using a new class of heavy-tailed distributions; Type 1 Heavy-Tailed Gamma (T1HT-G) distribution as baseline. The maximum likelihood parameters estimation approach was adopted for estimating the model parameters. Also, the Monte Carlo simulation approach was adopted to assess the performance of the maximum likelihood parameter estimation. Deviance information criteria such as AIC, BIC and CAIC were adopted to measure the models’ performance. The simulation studies were conducted using three different sample sizes and 50 replications. Results from the model applications using real life biological and biomedical data. Comparative measures from the models TI-HTG mixture cure rate (AIC=51.60, BIC=61.55, CAIC=52.08) were smaller which showed the adequacy of the models to provide better fit for heavy-tailed data than the well-- known standard distributions. These results have supported the fact that heavy tailed models provide better fits than the usual standard distributions when analyzing heavy-tailed data.

School students and staff can encounter a wide range of health-related emergencies, which, without proper management, can result in life-threatening consequences. Nurses, being the first health providers, should be well-prepared and equipped to handle these emergencies before emergency medical services arrive

Humanity has been wondering about the mechanisms of hearing for over 2,000 years. Many theories have been developed trying to solve this problem. The organ of hearing is still the only sense organ that is not fully understood. There is no doubt that the truth about hearing is different from the one proclaimed by the orthodox theory of hearing under the name of Bekesy's traveling wave. In order to change the seemingly erroneous status quo in explaining the mechanisms of hearing, I propose to start an analysis of all the circumstances that appeared after the announcement of the traveling wave theory. A new picture of hearing is emerging, significantly different from that described in textbooks and numerous publications. Censorship by orthodox reviewers can no longer inhibit new knowledge about hearing. This paper indicates the gaps in the current hearing theory and presents a new philosophy of hearing

SARS-CoV-2 evolution has undergone several mutations since its initial emergence in late 2019. Successive mutations are a common characteristic of RNA viruses like coronavirus. The emergence of new variants is a result of mutations that differ in their characteristics such as their infectiousness and mortality. Several variants of concern have been identified since the start of the pandemic, including Alpha, Beta, Gamma, Delta, and Omicron. Each of these variants showed unique mutations that raised concerns about their transmission rate, disease severity, and vaccine efficacy. The omicron variant (XBB 1.6), also known as B.1.1.529, attracted significant attention due to its high number of mutations, particularly in the spike protein. These mutations have raised concerns about potential impacts on vaccine efficacy and their ability to evade immunity.

Introduction: There cardiomyopathy hypertrophic ( CMH ) is a structural cell disease cardiac , provider of dead sudden at the house of THE youth of less 40 years old . The association with A syndrome of Wolff - Parkinson -W hite (WPW) was describe but stay However​ rare . We let's report A case of a cardiomyopathy hypertrophic associated has A syndrome of Wolf parkinson white .

Background: Percutaneous coronary artery angiography (CAG) is commonly performed all over the world through the transfemoral approach (TFA) but now a days the transradial approach (TRA) for CAG is becoming popular in the world. And recently has gained acceptance among Bangladeshi interventional cardiologists. The aim of this study was to document novice single operator experience of the trans-radial approach to CAG and to examine the utility of dual hand circulation assessment prior to the TRA for assessing the procedural outcomes among the patients in a tertiary care hospital in Bangladesh.

Ranula is a pocket of mucus that forms under the tongue due to blockage of the salivary glands, usually causing swelling and discomfort. Treatment can range from conservative measures, such as hot compresses, to surgical interventions to drain or remove the affected gland. This article reports the case of a ranula in an 11-year-old patient, which was clinically diagnosed and confirmed after the marsupialization technique. The histopathological examination revealed typical characteristics, such as thin epithelial lining and the presence of mucin, proving the diagnostic hypothesis. The treatment was effective, contributing to the clinical and histopathological understanding of this condition. This case report contributes to the existing literature by providing clinical and histopathological insights that can guide healthcare professionals in effectively managing this condition

Cu2FeSnSe4 (CFTSe) thin film were synthesized on glass substrate by thermal evaporation method at Ts=400° C, starting from elemental powders mixed by a mechanical alloying process. The structural, morphological, compositional, optical and electrical properties of CFTSe semiconductor have been investigated by X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray analysis (EDAX), spectroscopic ellipsometry (SE) and Van Der Pauw technique, respectiv

To describe a case of a 39-years-old man with marked scleral thinning secondary to proton beam therapy for choroidal melanoma. Observations: The patient underwent multiple unsuccessful reconstructive surgical procedures complicated by failure and enucleation was finally suggested. However, he started improving following homologous serum drops administration

Undernutrition is a leading cause of disease susceptibility, morbidity, and mortality in children. It is manifested in the form of stunting and wasting. Wasting is an acute form of undernutrition that indicates a recent food shortage and/or infectious diseases that lead to rapid and severe weight loss. The current study aimed to assess the prevalence and associated factors of stunting and wasting among under-five-aged children of displaced families in the North Gondar Zone. A cross-sectional study design was conducted from January to March 2022 among the under-five-aged children of the displaced family. A total of 205 randomly selected under-five-aged children from the displaced families were included in the study. A structured questionnaire was used to collect data, and the instrument was adopted from a previous study. Anthropometric measurements were carried out to determine the status of stunting and wasting. A bivariable and multivariable logistic regression analysis was used to find the factors associated with stunting and wasting. The prevalence of stunting and wasting among under-five-aged children was 26.2% and 18.7%, respectively. Out of the risk factors considered in the present study, age (AOR = 3.54; 95% CI: 0.2–3.54), family monthly income (AOR = 3.6; 95% CI: 1.3–7.5), eating only two meals per day (AOR = 2.8; 95% CI: 1.0–6.2), and not eating farm animal products (AOR = 2.2; 95% CI: 0.5–1.61) were important risk factors associated with stunting. In the other way, age, family monthly income, and eating only two meals per day were significant predictors of wasting. The result showed that the prevalence is severe in the study area. Therefore, the government should work on children under two years of age, take action to solve the nutritional issues, and encourage families with low monthly incomes to eat animal products at least once a week and nutritious food at least three times a day

Recycling is an important tool to cope with and sustainably manage rapidly increasing waste generation, and promoting local practices such as informal recycling is vital in developing countries. is study identies determinants of informal recycling that residents of Kathmandu Valley, Nepal practice by selling the recyclable waste to scrap dealers. e data comes from a households survey conducted with around 1200 households in the Valley in 2012. Informal recycling is important because it complements inecient and expensive waste collection services, diverts waste from the landll site, and helps the city to develop sustainably. We found that people who compost are 11.8 to 12.8 percent more likely to recycle in comp

Desalination has become one of the main alternatives to compensate for water shortages. Although seawater desalination is expensive and has many environmental risks, it is still an important option to compensate for water shortages in Egypt. The discharge of liquid waste (especially heavy metals) from the station into the sea has a negative impact on the water, so the spatial distribution of heavy metals (lead, cadmium, and copper) shows high concentrations near the outlets of both AlQusayr and the port of Al-Qusayr. Hamata desalination plants in the southern Red Sea. As for higher quantities of heavy metals - higher than the standard values - such as (Cu, Pb, Cd), they are classified as seawater pollutants, whether they show evidence of toxicity or not. The study demonstrated that seaweed has bio-absorption properties and can effectively absorb heavy metals from the surrounding water, and thus it can serve as a bio-indicator in tools for monitoring the degree of pollution, as well as evaluating water desalination activities

Toxicology deals with the measurement and analysis of toxins. It is itself a vast branch of science, though it has several branches and one of these is forensic toxicology. Forensic toxicology is a branch of toxicology that lines up with other disciplines, namely clinical chemistry, postmortem forensic toxicology, human performance toxicology and forensic drug testing, providing medical jurisprudence of adverse effects such as drug abuse, poisoning and death. The key role of forensic toxicology is to identify and analyse the toxin compounds found during adverse events. This review paper aims to draw an idea about the toxin, in the collected biological chemical samples such as urine samples and their effects on their day-to-day life

The determination of the postmortem interval (PMI) towards assisting in medicolegal investigations is a frequent requirement in any developed jurisdiction. Each of the latter has prevailing peculiarities, especially with many operating variables that include seasonal changes. There is a dearth of information about the decompositional pattern and progress of cadavers deposited on the ground in Nebraska, a jurisdiction lying within the Central Great Plains of North America. The present study, using an experimental pig was designed to consider the entomological peculiarities within a geographical area exhibiting taphonomic characteristics, and during a defined season.

In Ghana, where pristine waters once flowed freely, a dark tide of transboundary pollution casts a shadow. Illegal mining, a hydra-headed monster, spews its venom into rivers and streams, poisoning ecosystems and threatening communities across borders. This qualitative study, based on a meticulous analysis of 45 key papers, dives deep into the causes and consequences of this environmental scourge.

Background and Objective: Septic shock remains an impatient cause of morbidity and mortality. Early restitution of the circulation improve tissue oxygen delivery and increase survival. This study is a prospective randomized single center study its main objective is to investigate the therapeutic value of hypertonic saline in patients with septic shock. Methods: Fifty-two critically ill patients admitted with septic shock divided into two groups, the first group received isotonic saline (control group) starch, while the second received hypertonic saline 5%.

Androgen Insensitivity Syndrome (AIS), also known as testicular feminization, is a rare medical condition that has garnered increased attention in recent years due to evolving research and therapeutic approaches [1,2], as well as the psychological repercussions it has on patients and the risk of being associated not only with sex cord–stromal tumors but also with rare mesenchymal tumors [3]. AIS results from anomalies in the X chromosome and leads individuals with an XY genotype to exhibit various degrees of female physical traits or complete feminine characteristics