Recent Articles

Combining low-dose CT lung cancer screening (LCS) with smoking cessation has emerged as a next‐generation interven tion to reduce the human and societal burdens of lung cancer. is study reviews the evidence supporting both strate gies—individually and in combination—acknowledging that not all real-world smoking cessation interventions can be seam lessly integrated with LCS. While linking these strategies might enhance their respective primary endpoints, it is essential to ensure their integration does not inadvertently interfere with their individual outcomes. We present results of a survey on current best practices in the EU27 and propose key areas for further research. ese insights provide a foundation for future EU Commission-funded projects.

The anti-inflammatory activity of three samples of Indomethacin (IND-S1, IND-S2, IND-F) was evaluated in two models of acute inflammation (systemic and topical) and in the model of chronic inflammation. The three sample was solubilized in Tween 80:H2 O 1:9, was tested at 20 mg/kg and was administered by intragastric route. In first evaluation, the sample IN D-S1 at 20 mg/kg showed 57.09% inhibition on carrageenan-Induced plantar edema model. The evaluation at this same dose of Indomethacin from 3 different samples (IND-S1, IND-S2, IND-F) showed a variation in the % inhibition with 34.61, 30.13 and 32.69%, respectively. On the other hand; topical anti-inflammatory activity was evaluated in the TPA mod el acute in female Balb/C mice. IND-S1 showed an ED50 = 1.31 mg/ear and at a dose of 2 mg/ear showed 56.41% of inhibi tion. IND-S1, IND-S2 and IND-F at a dose of 2 mg/ear were more active with 87.39, 90.13 and 75.87%, respectively. In the chronic model of ear edema-TPA, when the IND-S1 was administered by i.g. route at 10 mg/kg, it showed high mortality (10/10), however at dose of 8 mg/kg, IND-S1 showed a 60.63% inhibition of ear edema, but in this assay 4/10 mice head. In same assay (TPA) but the IND was administered by topic route at repeated dose of 2 and 1 mg/ear, it cuased the death of all animals and at dose of 0.5 mg/ear caused about 50% of animals deaths

Tuberculosis is a worldwide health problem and is one of the 10 causes of death caused by a single infectious agent. It main ly affects the economically active population. Currently, there are multidrug-resistant and extended-resistance strains that are difficult to treat. In addition, several factors such as AIDS/HIV, diabetes, cancer and/or arthritis contribute to its persis tence, despite having first- and second-line drugs for its treatment. For this reason, it is necessary to contribute to find or search a new treatment alternatives and medicinal plants are an important source of bioactive compounds to be considered.

The present study has evaluated the effects of different inclusion levels of full fat black soldier fly (BSF) (Hermetia illucens L.) larva meal on the growth performance, carcass yield, organ development and gut pH of broiler chickens. A total of nine ty Cobb 500 broiler chicken of mixed sex were reared from day 21 to day 49 and assigned to 5 dietary treatments replicated thrice with 6 birds per replicate. The BSF larva meal was included at varied levels (0, 7.5%, 15%, 22.5% and 30%) in isoni trogenous and isoenergetic diets formulated for finisher feeding phase. One chicken per pen were slaughtered at day 49 for evaluation of carcass yield, organ development and gut pH. Data was analyzed using Statistical Analysis System software (SAS, 2009) and significant means were separated using Tukey Honest Significant Difference (HSD). The results showed that the total and weekly feed intake was not affected. Live, dressed, carcass weights, total weight gained, average daily weight gain showed a significant (P

Background: Acral fibromyxoma (AFM) is a rare benign soft tissue tumor which is described as fibromatous and myxoid tumor of skin and soft tissue. Case details: A 40 year old male presented to Dematology outpatient department with swelling over the wrist for one year duration.The swelling was associated with mild pain and it gradually increased in size to reach the present size. Cutaneous examination revealed a 2x2cm mobile,cystic to firm, non-tender swelling over dorsum of right wrist. Based on its location and clinical feature,it was provisionally diagnosed to be ganglion cyst and excision biopsy was done. Histology showed stellate shaped cells in myxoid background with round to oval nuclei having small inconspicious nucleolus

Necrotizing granulomatous inflammation in swellings which are clinically diagnosed as ganglion cyst is a rare entity due to the non-specific clinical presentation, insidious course, and large number of mimickers at this the particular site.Our patient is a 47 year/female who presented with a swelling over wrist for one year. On examination it was found to be firm, lobulated, mobile swelling, non-tender. USG showed cystic soft tissue swelling with a impression of ganglion cyst. Grossly the swelling was measuring 4x4 cm which was gradually progressive, increasing in size. This case report highlights the rare site of a granulomatous fungal inflammation clinically presenting as a multilocular ganglion cyst

A nodular subcutaneous swelling at elbow in an elderly patient should raise suspicion of infection or malignancy. A 63 year male patient presented with painful swelling in right elbow which was present for two years. It was insidious in onset and gradually increased to the present size. Clinical examination revealed a 6x5x5cm soft swelling, compressible, non-reducible, tender and overlying skin was pinch able. The uric acid level was 8.3mg/dl which was within normal limit. Patient complained that pain worsened on intake of alcohol and used to subside upon medication. The main clinical differential diagnosis were bursitis and gouty arthritis. On histopathological examination it revealed Gouty arthritis after ruling out granulomatous inflammation, foreign body giant cell reaction.

Introduction: Adult patients undergoing orthodontic treatment usually show signs of unbalanced occlusion, which can lead to serious health problems. Any imbalance in the body requires increased energy input for adaptation. Over time, this can lead to maladaptation and the formation of pathology throughout the body. For this reason, the examination of such patients requires special attention and the treatment demands unconventional approach

To meet people's yearning for a better life and the needs of agricultural production services, we must use soil water resources sustainably and carry out Agriculture high-quality development. So, we must estimate and take the suitable initial planting density to sow or plant to ensure Plant conservation density in the critical period of plant resources relation regulation reach the vegetation carry capacity to get the maximum yield and beneficial result. However, there are few reports on the estimation method of suitable initial planting density. In this pater, we put forward a method to estimating the suitable initial planting density, and take the perennial plant, caragana in the semiarid loess hilly region and one year plant, pepper in Xunhua, China as an example to determine. The results showing that the estimation method of suitable initial planting density is different for perennial plant caragana and one year plant, we can estimate the suitable initial planting density according to the soil dryness degree of control in the first year in the shrubland of semiarid region. As for a year plant pepper, we can estimate suitable initial planting density according to the area occupied by standard plant with maximum yield and beneficial result in the end of growth season.

Spatial analysis is an essential component of Geographic Information Systems (GIS) and is widely used for various purposes. One of its primary applications is to assess the suitability of a location for specific systems or to make accurate weather predictions for a particular geographic area. By utilizing spatial analysis, users can effectively model problems and find comprehensive solutions that incorporate geographical attributes

Background: Due to recent advancements in technology, workplace settings are becoming more inhabitant leading to a growing rate of sedentary behaviour during occupational duties. Sedentary behaviour is associated with increased cardiometabolic risks and poor health outcomes

Flood vulnerability modeling has become essential due to the impact of climate change on the environment. The Ogbese area of Nigeria frequently experiences significant flooding, primarily caused by torrential rainfall that leads to the overflow of local rivers. This study aims to model and map flood vulnerability in the Ogbese Catchment area in Ayede-Ogbese. Advanced analytical techniques, including Remote Sensing (RS), Hydraulic Engineering Center-River Analysis Software (HEC-RAS), and Geographical Information System (GIS) software (ArcGIS 10.7), were utilized for flood modeling and mapping in the study area. The data used in this research includes a topographic map of Ondo State for delineating the study area, Operational Landsat Imageries (OLI) for extracting land use and land cover (LULC), hydrological data (river discharge) for flood frequency analysis, and Advanced Land Observing Satellite (ALOS) Digital Elevation Map (DEM) for geometric data extraction and generating a Triangulated Irregular Network (TIN) dataset

Sympathy- seeking behavior or “sadfishing”, the act of exaggerating emotional distress on social media to gain “attention, satisfaction and support system. In recent years, this kind of act have rise of social media platform. This has become online interactions and potential psychology and social effects of behavior have become topics of interest. This study was prevalence and implication was done among the individuals through Questionnaire. Which was surveyed among college student. The Questionnaire covered key aspects of the participants in three dimension like attention, satisfaction and support system. The study provides valuable insights into the emerging phenomenon of sadfishing, though it also presented limitations such as potential self-report biases and lack of contextual depth. Future research could benefit from integrating observational methods and experimental designs to build a more nuanced understanding of sadfishing and its implications in the digital age

Early copper deficiency detection is important for sheep, a sensitive animal to copper (Cu) nutrition. Diagnosis through blood copper, ceruloplasmin, and superoxide dismutase 1 (SOD1) enzymes is not ideal due to the multifactorial control of these parameters. The copper chaperone for superoxide dismutase (CCS) protein is reported to be a specific biomarker for Cu deficiency in cattle and mice but not in sheep

Data of patients still alive 10 years after initial treatment for multiple myeloma (MM) were collected by 13 Italian hematological centers from January 2020 to December 2022. Routine work-up at diagnosis and type of treatment of 201 patients were analyzed from December 2023 to March 2024

Background: Calprotectin (CPL) is a marker of neutrophil-induced inflammation. Objective: Assess whether salivary CPL could be a useful marker of chronic inflammation. Methods: All relevant data were collected about patients who consulted from 2024 October 20th to December 20th and who had a previous medical history of periodontitis (PO).Patients were classified according to the level of salivary CPL. The CPL threshold for active PO and/or Fusobacterium nucleatum + Porphyromonas gingivalis (Fn+Pg) on dental collets was determined. Patients with PO remission, without Fn+Pg on dental collets and below the identified threshold were attributed to group A. Other patients were attributed to group B. Both groups were compared

Background: This study examined the rising incidence and prevalence of Chronic Kidney Disease (CKD) across age, gender, and regions in Himachal Pradesh to inform targeted public health strategies. Methods: CKD incidence data were collected from various age groups, gender, and blocks. Statistical analyses, including chi-square tests, were used to assess the significance of differences in CKD case distribution by age, gender, temporal and region. Results: The significant spatial, temporal, gender, and age-related variations in Chronic Kidney Disease (CKD) prevalence across Himachal Pradesh (2014–2023), with Shimla showing the highest prevalence. CKD disproportionately affects male (60.2%) Mashobra (20.4%) reports the highest CKD cases, followed by Theog (12.3%), and Kupvi (2.4%) the lowest. Significant gender differences across blocks are confirmed (χ² = 26.436, p < .01). Chi-square analysis (χ² = 18.423, p < .05) revealed significant gender disparities in CKD cases from 2014 to 2023, with peaks in 2023 (16.9%) and a low in 2017 (6%). Chisquare analysis (χ² = 41.076, p < .000) showed a significant age-gender association in CKD, with the highest number of cases in 57–67 years (637) and lowest in

The Plasmodium falciparum T-cell immunomodulatory protein homolog, PfTIP, is a novel invasion-related protein that is thought to play additional roles in modulating host immune responses to the infection. We examined the cellular localiza tion and secretion patterns of PfTIP in laboratory cultured Plasmodium falciparum parasites and in naturally infected indivi duals, and investigated the association between plasma levels of the protein and host immune responses

According to UN-Habitat, slums are characterized by the absence of several essential living conditions, including durable housing that others protection against severe climatic conditions, insufficient living space, inadequate sanitation, and limited access to safe water [1]

The existence of the fighting bull, exploited in the poor pastures in the interior of Terceira Island, allowed the preservation of the largest area of endemic a 20-million-year-old subtropical rainforest called Laurissilva [1]. The fighting bull is the symbol of the preservation carried out by some of these men, the cattle farmers [2]. The appearance of the first cattle in the Azores oc curred in the 15th century, in line with the discovery and settlement by the Portuguese [3]. In addition to being an important source of protein for emerging populations, interaction with cattle also took on a playful nature, taking advantage of the aggres siveness of these cattle raised in the interior of the islands, particularly on Terceira Island [4]. The aggressive cattle, which are the precursors of the Brava dos Açores cattle population, had and continue to play an important economic and socio-cultural role, particularly in maintaining the tradition of rope bullfight, called “Tourada à Corda”, unique in the country and which is practically dispersed across 5 of the 9 islands from the Azores [5].