Articles Related to Gynecology

The World Health Organization declared COVID-19 a pandemic in March 2020 and since then COVID-19 infection has been reported in all parts of the world. Several Healthcare systems reduced or canceled none emergency or urgent surgeries to effectively manage the pandemic. Recently, the reported incidence of new cases of COVID-19 has reduced in some regions and some Healthcare systems are resuming elective gynecologic surgery. This narrative review explores the challenges of planning and resuming elective gynecologic surgery in a climate of continuing community transmission.

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Preeclampsia is clinically defined by hypertension and proteinuria, with or without pathologic edema that occurs after 20 weeks’ gestation, but can also present up to 4-6 weeks post-partum. Worldwide, incidence of preeclampsia is 5-14 percent of all pregnancies, while severe preeclampsia can develop to about 25 percent of all cases of preeclampsia.

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Studies comparing robotic-assisted laparoscopic surgery (RALS) and conventional laparoscopic surgery (CLS) suggest that the two approaches have similar outcomes. However, RALS leads to higher cost and longer operative time. We sought to investigate patient perceptions of RALS for benign gynecologic pathology.

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In the United States (U.S.), the costs for health care and lost productivity due to diagnosed diabetes has increased from $174 billion in 2007 to $245 billion in 2012, making it one of the fastest growing public health burdens. Nearly 26 million adults have diabetes, and another 79 million have prediabetes, a condition that increases the risk for developing type 2 diabetes. Clearly to reduce the costs and improve health, preventing diabetes must be a priority.

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NovaSure® endometrial ablation is a successful therapy for patients with heavy menstrual bleeding who do not want to preserve fertility. However, endometrial ablation is not a contraceptive treatment. We report two cases of pregnancy after NovaSure® endometrial ablation. Case 1 is a pregnancy in a 44-year old woman.

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The high mortality associated with ovarian cancer is generally related to the development of drug-resistant disease. HMGA2 protein, a member of the high-mobility group AT-hook (HMGA) family of non-histone chromatin binding factors, is overexpressed in high-grade serous ovarian and tubal carcinomas, though little is known about its contribution to disease progression and drug resistance. We sought to assess whether compositional changes in HMGA2 production were associated with ovarian cancer progression.

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Ovarian cancer constitutes the second most common gynecological cancer with a five-year survival rate of 40%. Among the various histotypes associated with hereditary ovarian cancer, high-grade serous epithelial ovarian carcinoma (HGSEOC) is the most predominant and women with inherited mutations in BRCA1 have a lifetime risk of 40-60%. HGSEOC is a challenge for clinical oncologists, due to late presentation of patient, diagnosis and high rate of relapse. Ovarian tumors have a wide range of clinical presentations including development of ascites as a result of deregulated endothelial function thereby causing increased vascular permeability of peritoneal vessels.

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A monoclonal antibody (Mab) designated as GHR106 was generated against the extracellular domain (N1-29 synthetic peptide) of human gonadotropin releasing hormone (GnRH) receptor. It is a first-in-class GnRH analog and can serve as a drug candidate for potential applications in the treatment of human cancers and/or fertility regulations.

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Minilaparotomy has been used for tubal sterilization for decades. It became a new surgical idea described by some who performed minilaparotomy hysterectomy and achieved outcomes that were less invasive than those of traditional open laparotomy. Pelosi and Pelosi 2004 reported a minilaparotomy procedure in patients in whom vaginal hysterectomy was considered contraindicated. Their procedure offered a safe alternative with minimal access and good outcome.

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Seventeen alpha hydroxyprogesterone caproate (17-OHPC) is the only FDA-approved drug labeled for prevention of preterm delivery. This drug is also available as a compounded product from licensed compounding pharmacies. This article reviews the FDA approval history and pharmacy compounding quality control data of 17-OHPC, as well as briefly discusses possible future pharmaceutical development strategies for 17-OHPC.

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